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- PSME_00030756-RA
PSME_00030756-RA
Description : (at5g55310 : 94.0) Encodes one of two Arabidopsis type-I DNA topoisomerase I genes. Reducing the level of expression of this gene in a top1alpha (At5g55300) mutant background causes seedling lethality.; DNA topoisomerase 1 beta (TOP1BETA); FUNCTIONS IN: DNA topoisomerase type I activity; INVOLVED IN: DNA topological change; LOCATED IN: membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type (InterPro:IPR013030), DNA topoisomerase I, DNA binding, eukaryotic-type (InterPro:IPR008336), DNA topoisomerase I, C-terminal (InterPro:IPR001631), DNA topoisomerase I, active site (InterPro:IPR018521), DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type (InterPro:IPR014727), DNA topoisomerase I, catalytic core, eukaryotic-type (InterPro:IPR013500), DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type (InterPro:IPR014711), DNA topoisomerase I, C-terminal, eukaryotic-type (InterPro:IPR013499), DNA breaking-rejoining enzyme, catalytic core (InterPro:IPR011010); BEST Arabidopsis thaliana protein match is: DNA topoisomerase I alpha (TAIR:AT5G55300.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink). & (p93119|top1_dauca : 87.4) DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) - Daucus carota (Carrot) & (reliability: 188.0) & (original description: no original description)
Expression Profile
Attention: This gene has low abundance.
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Co-expression Networks
| Type | Description | Actions |
| Neighborhood | Pseudotsuga release: PSME_00030756-RA | |
| Cluster | HCCA clusters: Cluster_298 | |
Functional Annotation
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0003674 | molecular_function | None | Extended |
| MF | GO:0003676 | nucleic acid binding | None | Extended |
| MF | GO:0003677 | DNA binding | IEA | InterProScan predictions |
| MF | GO:0003824 | catalytic activity | None | Extended |
| MF | GO:0003916 | DNA topoisomerase activity | None | Extended |
| MF | GO:0003917 | DNA topoisomerase type I activity | IEA | InterProScan predictions |
| MF | GO:0005488 | binding | None | Extended |
| CC | GO:0005575 | cellular_component | None | Extended |
| CC | GO:0005694 | chromosome | IEA | InterProScan predictions |
| BP | GO:0006139 | nucleobase-containing compound metabolic process | None | Extended |
| BP | GO:0006259 | DNA metabolic process | None | Extended |
| BP | GO:0006265 | DNA topological change | IEA | InterProScan predictions |
| BP | GO:0006725 | cellular aromatic compound metabolic process | None | Extended |
| BP | GO:0006807 | nitrogen compound metabolic process | None | Extended |
| BP | GO:0006996 | organelle organization | None | Extended |
| BP | GO:0008150 | biological_process | None | Extended |
| BP | GO:0008152 | metabolic process | None | Extended |
| BP | GO:0009987 | cellular process | None | Extended |
| BP | GO:0016043 | cellular component organization | None | Extended |
| MF | GO:0016853 | isomerase activity | None | Extended |
| BP | GO:0034641 | cellular nitrogen compound metabolic process | None | Extended |
| BP | GO:0043170 | macromolecule metabolic process | None | Extended |
| CC | GO:0043226 | organelle | None | Extended |
| CC | GO:0043228 | non-membrane-bounded organelle | None | Extended |
| CC | GO:0043229 | intracellular organelle | None | Extended |
| CC | GO:0043232 | intracellular non-membrane-bounded organelle | None | Extended |
| BP | GO:0044237 | cellular metabolic process | None | Extended |
| BP | GO:0044238 | primary metabolic process | None | Extended |
| BP | GO:0044260 | cellular macromolecule metabolic process | None | Extended |
| CC | GO:0044424 | intracellular part | None | Extended |
| CC | GO:0044464 | cell part | None | Extended |
| BP | GO:0046483 | heterocycle metabolic process | None | Extended |
| BP | GO:0051276 | chromosome organization | None | Extended |
| BP | GO:0071103 | DNA conformation change | None | Extended |
| BP | GO:0071704 | organic substance metabolic process | None | Extended |
| BP | GO:0071840 | cellular component organization or biogenesis | None | Extended |
| BP | GO:0090304 | nucleic acid metabolic process | None | Extended |
| MF | GO:0097159 | organic cyclic compound binding | None | Extended |
| MF | GO:0140097 | catalytic activity, acting on DNA | None | Extended |
| BP | GO:1901360 | organic cyclic compound metabolic process | None | Extended |
| MF | GO:1901363 | heterocyclic compound binding | None | Extended |
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0003697 | single-stranded DNA binding | IEP | Predicted GO |
| MF | GO:0004252 | serine-type endopeptidase activity | IEP | Predicted GO |
| MF | GO:0005092 | GDP-dissociation inhibitor activity | IEP | Predicted GO |
| MF | GO:0005094 | Rho GDP-dissociation inhibitor activity | IEP | Predicted GO |
| BP | GO:0006606 | protein import into nucleus | IEP | Predicted GO |
| BP | GO:0006886 | intracellular protein transport | IEP | Predicted GO |
| BP | GO:0006913 | nucleocytoplasmic transport | IEP | Predicted GO |
| MF | GO:0008017 | microtubule binding | IEP | Predicted GO |
| BP | GO:0008104 | protein localization | IEP | Predicted GO |
| BP | GO:0015031 | protein transport | IEP | Predicted GO |
| BP | GO:0015833 | peptide transport | IEP | Predicted GO |
| BP | GO:0017038 | protein import | IEP | Predicted GO |
| MF | GO:0019899 | enzyme binding | IEP | Predicted GO |
| BP | GO:0033036 | macromolecule localization | IEP | Predicted GO |
| BP | GO:0033365 | protein localization to organelle | IEP | Predicted GO |
| BP | GO:0034504 | protein localization to nucleus | IEP | Predicted GO |
| BP | GO:0034613 | cellular protein localization | IEP | Predicted GO |
| BP | GO:0042886 | amide transport | IEP | Predicted GO |
| BP | GO:0045184 | establishment of protein localization | IEP | Predicted GO |
| BP | GO:0046907 | intracellular transport | IEP | Predicted GO |
| BP | GO:0051169 | nuclear transport | IEP | Predicted GO |
| BP | GO:0051170 | import into nucleus | IEP | Predicted GO |
| BP | GO:0051641 | cellular localization | IEP | Predicted GO |
| BP | GO:0051649 | establishment of localization in cell | IEP | Predicted GO |
| MF | GO:0061608 | nuclear import signal receptor activity | IEP | Predicted GO |
| BP | GO:0070727 | cellular macromolecule localization | IEP | Predicted GO |
| BP | GO:0072594 | establishment of protein localization to organelle | IEP | Predicted GO |
| MF | GO:0140104 | molecular carrier activity | IEP | Predicted GO |
| MF | GO:0140142 | nucleocytoplasmic carrier activity | IEP | Predicted GO |
| InterPro domains | Description | Start | Stop |
| IPR008336 | TopoI_DNA-bd_euk | 236 | 306 |
