Description : (q8w013|comt1_catro : 270.0) Caffeic acid 3-O-methyltransferase (EC 2.1.1.68) (S-adenosysl-L-methionine:caffeic acid 3-O-methyltransferase) (COMT) (CAOMT) - Catharanthus roseus (Rosy periwinkle) (Madagascar periwinkle) & (at5g54160 : 249.0) A caffeic acid/5-hydroxyferulic acid O-methyltransferase. Interacts with 14-4-3 proteins in yeast 2 hybrid assay. AtOMT1 (At5g54160) encodes a flavonol 3Ã-O-methyltransferase that is highly active towards quercetin and myricetin. The substrate specificity identifies the enzyme as flavonol 3Ã-methyltransferase which replaces the former annotation of the gene to encode a caffeic acid/5-hydroxyferulic acid O-methyltransferase; O-methyltransferase 1 (OMT1); FUNCTIONS IN: myricetin 3'-O-methyltransferase activity, quercetin 3-O-methyltransferase activity, caffeate O-methyltransferase activity; INVOLVED IN: lignin biosynthetic process, flavonol biosynthetic process; LOCATED IN: cytosol, nucleus, plasma membrane, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Plant methyltransferase dimerisation (InterPro:IPR012967), O-methyltransferase, family 2 (InterPro:IPR001077), O-methyltransferase, COMT, eukaryota (InterPro:IPR016461); BEST Arabidopsis thaliana protein match is: O-methyltransferase family protein (TAIR:AT1G77520.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink). & (reliability: 490.0) & (original description: no original description)
Gene families : OG_42_0000016 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000016_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | Pseudotsuga release: PSME_00037447-RA | |
Cluster | HCCA clusters: Cluster_32 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
HORVU7Hr1G117890.1 | No alias | EC_2.1 transferase transferring one-carbon group | 0.02 | Orthogroups_2024-Update | |
LOC_Os07g27970 | No alias | O-methyltransferase, putative, expressed | 0.02 | Orthogroups_2024-Update | |
PSME_00006686-RA | No alias | (q9fqy8|comt1_capan : 349.0) Caffeic acid... | 0.05 | Orthogroups_2024-Update | |
PSME_00008876-RA | No alias | (p93324|chomt_medsa : 161.0) Isoliquiritigenin... | 0.04 | Orthogroups_2024-Update | |
PSME_00008877-RA | No alias | (q8w013|comt1_catro : 225.0) Caffeic acid... | 0.04 | Orthogroups_2024-Update | |
PSME_00023722-RA | No alias | (p28002|comt1_medsa : 233.0) Caffeic acid... | 0.04 | Orthogroups_2024-Update | |
PSME_00037662-RA | No alias | (q8w013|comt1_catro : 274.0) Caffeic acid... | 0.04 | Orthogroups_2024-Update |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0008171 | O-methyltransferase activity | IEA | InterProScan predictions |
MF | GO:0046983 | protein dimerization activity | IEA | InterProScan predictions |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0000166 | nucleotide binding | IEP | Predicted GO |
MF | GO:0005524 | ATP binding | IEP | Predicted GO |
BP | GO:0006855 | drug transmembrane transport | IEP | Predicted GO |
MF | GO:0008144 | drug binding | IEP | Predicted GO |
BP | GO:0015893 | drug transport | IEP | Predicted GO |
CC | GO:0016459 | myosin complex | IEP | Predicted GO |
MF | GO:0016462 | pyrophosphatase activity | IEP | Predicted GO |
MF | GO:0016840 | carbon-nitrogen lyase activity | IEP | Predicted GO |
MF | GO:0016843 | amine-lyase activity | IEP | Predicted GO |
MF | GO:0016844 | strictosidine synthase activity | IEP | Predicted GO |
MF | GO:0017076 | purine nucleotide binding | IEP | Predicted GO |
MF | GO:0017111 | nucleoside-triphosphatase activity | IEP | Predicted GO |
MF | GO:0030554 | adenyl nucleotide binding | IEP | Predicted GO |
MF | GO:0032553 | ribonucleotide binding | IEP | Predicted GO |
MF | GO:0032555 | purine ribonucleotide binding | IEP | Predicted GO |
MF | GO:0032559 | adenyl ribonucleotide binding | IEP | Predicted GO |
MF | GO:0035639 | purine ribonucleoside triphosphate binding | IEP | Predicted GO |
MF | GO:0036094 | small molecule binding | IEP | Predicted GO |
MF | GO:0043168 | anion binding | IEP | Predicted GO |
CC | GO:0044430 | cytoskeletal part | IEP | Predicted GO |
MF | GO:0097159 | organic cyclic compound binding | IEP | Predicted GO |
MF | GO:0097367 | carbohydrate derivative binding | IEP | Predicted GO |
MF | GO:1901265 | nucleoside phosphate binding | IEP | Predicted GO |
MF | GO:1901363 | heterocyclic compound binding | IEP | Predicted GO |
No external refs found! |