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Description : (at1g48050 : 96.7) Ku80 and ku70 form the heterodimer complex Ku, required for proper maintenance of the telomeric C strand. Ku regulates the extension of the telomeric G strand. Interacts with WEX, and this interaction stimulates the WEX exonuclease activity. Binds double stranded DNA breaks as a heterodimer with Ku70, involved in non-homologous end joining repair. Mutants are defective in T-DNA integration. Over expression confers increased resistance to DNA damage agents and increased susceptibility to T-DNA transformation.; KU80; FUNCTIONS IN: double-stranded DNA binding, protein binding; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ku70/Ku80, N-terminal alpha/beta (InterPro:IPR005161), DNA helicase, ATP-dependent, Ku type (InterPro:IPR006164), Spen Paralogue and Orthologue SPOC, C-terminal-like (InterPro:IPR016194), Ku70/Ku80 C-terminal arm (InterPro:IPR005160), Ku, C-terminal (InterPro:IPR014893); Has 786 Blast hits to 750 proteins in 217 species: Archae - 0; Bacteria - 40; Metazoa - 246; Fungi - 345; Plants - 62; Viruses - 0; Other Eukaryotes - 93 (source: NCBI BLink). & (reliability: 193.4) & (original description: no original description)
Gene families : OG_42_0001893 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001893_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
| Type | Description | Actions |
|---|---|---|
| Neighborhood | Pseudotsuga release: PSME_00040052-RA | |
| Cluster | HCCA clusters: Cluster_56 |
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
|---|---|---|---|---|---|
| GRMZM2G137968 | No alias | Ku80 family protein | 0.02 | Orthogroups_2024-Update | |
| PSME_00031675-RA | No alias | (at1g48050 : 94.7) Ku80 and ku70 form the heterodimer... | 0.04 | Orthogroups_2024-Update | |
| PSME_00033536-RA | No alias | (at1g48050 : 111.0) Ku80 and ku70 form the heterodimer... | 0.04 | Orthogroups_2024-Update |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
No GO annotation available for this sequence |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| MF | GO:0003774 | motor activity | IEP | Predicted GO |
| MF | GO:0003777 | microtubule motor activity | IEP | Predicted GO |
| MF | GO:0004519 | endonuclease activity | IEP | Predicted GO |
| MF | GO:0004521 | endoribonuclease activity | IEP | Predicted GO |
| MF | GO:0004540 | ribonuclease activity | IEP | Predicted GO |
| BP | GO:0006928 | movement of cell or subcellular component | IEP | Predicted GO |
| BP | GO:0007017 | microtubule-based process | IEP | Predicted GO |
| BP | GO:0007018 | microtubule-based movement | IEP | Predicted GO |
| BP | GO:0007062 | sister chromatid cohesion | IEP | Predicted GO |
| BP | GO:0007064 | mitotic sister chromatid cohesion | IEP | Predicted GO |
| MF | GO:0016787 | hydrolase activity | IEP | Predicted GO |
| MF | GO:0016788 | hydrolase activity, acting on ester bonds | IEP | Predicted GO |
| BP | GO:0022402 | cell cycle process | IEP | Predicted GO |
| CC | GO:0031390 | Ctf18 RFC-like complex | IEP | Predicted GO |
| BP | GO:0051276 | chromosome organization | IEP | Predicted GO |
| BP | GO:1903047 | mitotic cell cycle process | IEP | Predicted GO |
No InterPro domains available for this sequence
| No external refs found! |