Description : (at1g48050 : 112.0) Ku80 and ku70 form the heterodimer complex Ku, required for proper maintenance of the telomeric C strand. Ku regulates the extension of the telomeric G strand. Interacts with WEX, and this interaction stimulates the WEX exonuclease activity. Binds double stranded DNA breaks as a heterodimer with Ku70, involved in non-homologous end joining repair. Mutants are defective in T-DNA integration. Over expression confers increased resistance to DNA damage agents and increased susceptibility to T-DNA transformation.; KU80; FUNCTIONS IN: double-stranded DNA binding, protein binding; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ku70/Ku80, N-terminal alpha/beta (InterPro:IPR005161), DNA helicase, ATP-dependent, Ku type (InterPro:IPR006164), Spen Paralogue and Orthologue SPOC, C-terminal-like (InterPro:IPR016194), Ku70/Ku80 C-terminal arm (InterPro:IPR005160), Ku, C-terminal (InterPro:IPR014893); Has 786 Blast hits to 750 proteins in 217 species: Archae - 0; Bacteria - 40; Metazoa - 246; Fungi - 345; Plants - 62; Viruses - 0; Other Eukaryotes - 93 (source: NCBI BLink). & (reliability: 224.0) & (original description: no original description)
Gene families : OG_42_0001893 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001893_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | Pseudotsuga release: PSME_00043235-RA | |
Cluster | HCCA clusters: Cluster_271 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
PSME_00033536-RA | No alias | (at1g48050 : 111.0) Ku80 and ku70 form the heterodimer... | 0.05 | Orthogroups_2024-Update |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | IEA | InterProScan predictions |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0003950 | NAD+ ADP-ribosyltransferase activity | IEP | Predicted GO |
MF | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds | IEP | Predicted GO |
CC | GO:0005576 | extracellular region | IEP | Predicted GO |
CC | GO:0005618 | cell wall | IEP | Predicted GO |
BP | GO:0005976 | polysaccharide metabolic process | IEP | Predicted GO |
BP | GO:0006606 | protein import into nucleus | IEP | Predicted GO |
BP | GO:0006886 | intracellular protein transport | IEP | Predicted GO |
BP | GO:0006913 | nucleocytoplasmic transport | IEP | Predicted GO |
BP | GO:0008104 | protein localization | IEP | Predicted GO |
MF | GO:0010333 | terpene synthase activity | IEP | Predicted GO |
BP | GO:0015031 | protein transport | IEP | Predicted GO |
BP | GO:0015833 | peptide transport | IEP | Predicted GO |
MF | GO:0016762 | xyloglucan:xyloglucosyl transferase activity | IEP | Predicted GO |
MF | GO:0016763 | transferase activity, transferring pentosyl groups | IEP | Predicted GO |
MF | GO:0016829 | lyase activity | IEP | Predicted GO |
MF | GO:0016838 | carbon-oxygen lyase activity, acting on phosphates | IEP | Predicted GO |
MF | GO:0016846 | carbon-sulfur lyase activity | IEP | Predicted GO |
BP | GO:0017038 | protein import | IEP | Predicted GO |
CC | GO:0030312 | external encapsulating structure | IEP | Predicted GO |
BP | GO:0033036 | macromolecule localization | IEP | Predicted GO |
BP | GO:0033365 | protein localization to organelle | IEP | Predicted GO |
BP | GO:0034504 | protein localization to nucleus | IEP | Predicted GO |
BP | GO:0034613 | cellular protein localization | IEP | Predicted GO |
BP | GO:0042886 | amide transport | IEP | Predicted GO |
BP | GO:0045184 | establishment of protein localization | IEP | Predicted GO |
BP | GO:0046907 | intracellular transport | IEP | Predicted GO |
CC | GO:0048046 | apoplast | IEP | Predicted GO |
BP | GO:0051169 | nuclear transport | IEP | Predicted GO |
BP | GO:0051170 | import into nucleus | IEP | Predicted GO |
BP | GO:0051641 | cellular localization | IEP | Predicted GO |
BP | GO:0051649 | establishment of localization in cell | IEP | Predicted GO |
MF | GO:0061608 | nuclear import signal receptor activity | IEP | Predicted GO |
BP | GO:0070727 | cellular macromolecule localization | IEP | Predicted GO |
BP | GO:0071702 | organic substance transport | IEP | Predicted GO |
BP | GO:0071705 | nitrogen compound transport | IEP | Predicted GO |
BP | GO:0072594 | establishment of protein localization to organelle | IEP | Predicted GO |
MF | GO:0140104 | molecular carrier activity | IEP | Predicted GO |
MF | GO:0140142 | nucleocytoplasmic carrier activity | IEP | Predicted GO |
InterPro domains | Description | Start | Stop |
---|---|---|---|
IPR014893 | Ku_PK_bind | 137 | 192 |
No external refs found! |