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Description : (at4g13930 : 784.0) Encodes a serine hydroxymethyltransferase maximally expressed in root; serine hydroxymethyltransferase 4 (SHM4); FUNCTIONS IN: pyridoxal phosphate binding, glycine hydroxymethyltransferase activity, catalytic activity; INVOLVED IN: response to cadmium ion, glycine metabolic process, L-serine metabolic process; LOCATED IN: cytosol, plasma membrane, membrane; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: seedling growth, seed development stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Serine hydroxymethyltransferase, pyridoxal phosphate binding site (InterPro:IPR019798), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Serine hydroxymethyltransferase (InterPro:IPR001085); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate (PLP)-dependent transferases superfamily protein (TAIR:AT4G13890.1); Has 11689 Blast hits to 11661 proteins in 2862 species: Archae - 259; Bacteria - 6437; Metazoa - 341; Fungi - 289; Plants - 375; Viruses - 6; Other Eukaryotes - 3982 (source: NCBI BLink). & (p34899|glym_pea : 531.0) Serine hydroxymethyltransferase, mitochondrial precursor (EC 2.1.2.1) (Serine methylase) (Glycine hydroxymethyltransferase) (SHMT) - Pisum sativum (Garden pea) & (reliability: 1568.0) & (original description: no original description)
Gene families : OG_42_0000626 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000626_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
| Type | Description | Actions |
|---|---|---|
| Neighborhood | Pseudotsuga release: PSME_00047747-RA | |
| Cluster | HCCA clusters: Cluster_218 |
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
|---|---|---|---|---|---|
| A4A49_31930 | No alias | serine hydroxymethyltransferase 7 | 0.02 | Orthogroups_2024-Update | |
| Glyma.14G184500 | No alias | serine hydroxymethyltransferase 2 | 0.02 | Orthogroups_2024-Update | |
| Sobic.003G373600.1 | No alias | serine hydroxymethyltransferase *(SHM) & serine... | 0.02 | Orthogroups_2024-Update |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
No GO annotation available for this sequence |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| MF | GO:0003678 | DNA helicase activity | IEP | Predicted GO |
| MF | GO:0003848 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity | IEP | Predicted GO |
| MF | GO:0004386 | helicase activity | IEP | Predicted GO |
| MF | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity | IEP | Predicted GO |
| MF | GO:0004576 | oligosaccharyl transferase activity | IEP | Predicted GO |
| MF | GO:0005048 | signal sequence binding | IEP | Predicted GO |
| MF | GO:0005488 | binding | IEP | Predicted GO |
| CC | GO:0005759 | mitochondrial matrix | IEP | Predicted GO |
| BP | GO:0006621 | protein retention in ER lumen | IEP | Predicted GO |
| BP | GO:0006760 | folic acid-containing compound metabolic process | IEP | Predicted GO |
| MF | GO:0008270 | zinc ion binding | IEP | Predicted GO |
| MF | GO:0008375 | acetylglucosaminyltransferase activity | IEP | Predicted GO |
| BP | GO:0009396 | folic acid-containing compound biosynthetic process | IEP | Predicted GO |
| MF | GO:0016645 | oxidoreductase activity, acting on the CH-NH group of donors | IEP | Predicted GO |
| MF | GO:0016646 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor | IEP | Predicted GO |
| MF | GO:0016778 | diphosphotransferase activity | IEP | Predicted GO |
| CC | GO:0030120 | vesicle coat | IEP | Predicted GO |
| CC | GO:0030126 | COPI vesicle coat | IEP | Predicted GO |
| CC | GO:0031974 | membrane-enclosed lumen | IEP | Predicted GO |
| BP | GO:0032507 | maintenance of protein location in cell | IEP | Predicted GO |
| MF | GO:0033218 | amide binding | IEP | Predicted GO |
| BP | GO:0035437 | maintenance of protein localization in endoplasmic reticulum | IEP | Predicted GO |
| MF | GO:0042277 | peptide binding | IEP | Predicted GO |
| MF | GO:0042393 | histone binding | IEP | Predicted GO |
| BP | GO:0042398 | cellular modified amino acid biosynthetic process | IEP | Predicted GO |
| BP | GO:0042558 | pteridine-containing compound metabolic process | IEP | Predicted GO |
| BP | GO:0042559 | pteridine-containing compound biosynthetic process | IEP | Predicted GO |
| MF | GO:0043167 | ion binding | IEP | Predicted GO |
| MF | GO:0043169 | cation binding | IEP | Predicted GO |
| CC | GO:0043233 | organelle lumen | IEP | Predicted GO |
| CC | GO:0044431 | Golgi apparatus part | IEP | Predicted GO |
| CC | GO:0044433 | cytoplasmic vesicle part | IEP | Predicted GO |
| BP | GO:0045185 | maintenance of protein location | IEP | Predicted GO |
| MF | GO:0046872 | metal ion binding | IEP | Predicted GO |
| MF | GO:0046914 | transition metal ion binding | IEP | Predicted GO |
| MF | GO:0046923 | ER retention sequence binding | IEP | Predicted GO |
| BP | GO:0051235 | maintenance of location | IEP | Predicted GO |
| BP | GO:0051651 | maintenance of location in cell | IEP | Predicted GO |
| BP | GO:0065008 | regulation of biological quality | IEP | Predicted GO |
| CC | GO:0070013 | intracellular organelle lumen | IEP | Predicted GO |
| BP | GO:0072595 | maintenance of protein localization in organelle | IEP | Predicted GO |
| InterPro domains | Description | Start | Stop |
|---|---|---|---|
| IPR039429 | SHMT-like_dom | 88 | 486 |
| No external refs found! |