PSME_00051796-RA


Description : (at2g30110 : 480.0) Encodes a ubiquitin-activating enzyme (E1), involved in the first step in conjugating multiple ubiquitins to proteins targeted for degradation. Gene is expressed in most tissues examined. Mutant is able to revert the constitutive defense responses phenotype of snc1, which indicates the gene is involved in defense response. It also indicates that ubiquitination plays a role in plant defense signalling.; ubiquitin-activating enzyme 1 (UBA1); FUNCTIONS IN: ubiquitin-protein ligase activity, ubiquitin activating enzyme activity; INVOLVED IN: response to cadmium ion, response to other organism, protein ubiquitination, ubiquitin-dependent protein catabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-activating enzyme, E1, active site (InterPro:IPR018074), Ubiquitin-activating enzyme, E1 (InterPro:IPR018075), Ubiquitin-activating enzyme e1, C-terminal (InterPro:IPR018965), Ubiquitin-activating enzyme repeat (InterPro:IPR000127), Ubiquitin-activating enzyme (InterPro:IPR019572), UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040), Ubiquitin-activating enzyme, E1-like (InterPro:IPR000011); BEST Arabidopsis thaliana protein match is: ubiquitin activating enzyme 2 (TAIR:AT5G06460.1); Has 19490 Blast hits to 12603 proteins in 2346 species: Archae - 393; Bacteria - 11015; Metazoa - 2131; Fungi - 1366; Plants - 791; Viruses - 0; Other Eukaryotes - 3794 (source: NCBI BLink). & (p31251|ube12_wheat : 470.0) Ubiquitin-activating enzyme E1 2 - Triticum aestivum (Wheat) & (reliability: 960.0) & (original description: no original description)


Gene families : OG_42_0011387 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0011387_tree

Sequence : coding (download), protein (download)


Attention: This gene has low abundance.


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Pseudotsuga release: PSME_00051796-RA
Cluster HCCA clusters: Cluster_87


Type GO Term Name Evidence Source
MF GO:0008641 ubiquitin-like modifier activating enzyme activity IEA InterProScan predictions
Type GO Term Name Evidence Source
MF GO:0005215 transporter activity IEP Predicted GO
CC GO:0005575 cellular_component IEP Predicted GO
BP GO:0006810 transport IEP Predicted GO
MF GO:0010181 FMN binding IEP Predicted GO
MF GO:0015399 primary active transmembrane transporter activity IEP Predicted GO
MF GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity IEP Predicted GO
CC GO:0016021 integral component of membrane IEP Predicted GO
MF GO:0022857 transmembrane transporter activity IEP Predicted GO
CC GO:0031224 intrinsic component of membrane IEP Predicted GO
MF GO:0042623 ATPase activity, coupled IEP Predicted GO
MF GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEP Predicted GO
MF GO:0043492 ATPase activity, coupled to movement of substances IEP Predicted GO
CC GO:0044425 membrane part IEP Predicted GO
MF GO:0048037 cofactor binding IEP Predicted GO
MF GO:0050662 coenzyme binding IEP Predicted GO
BP GO:0051179 localization IEP Predicted GO
BP GO:0051234 establishment of localization IEP Predicted GO
BP GO:0055085 transmembrane transport IEP Predicted GO
InterPro domains Description Start Stop
IPR000594 ThiF_NAD_FAD-bd 286 411
IPR032420 E1_4HB 155 224
IPR032418 E1_FCCH 81 154
IPR019572 UBA_E1_Cys 428 503
No external refs found!