Description : (p35063|h2ax_picab : 225.0) Histone H2AX - Picea abies (Norway spruce) (Picea excelsa) & (at1g54690 : 202.0) Encodes HTA3, a histone H2A protein. H2AX is a meiosis-specific isoform of histone H2A. Upon DSB formation, rapid accumulation of phosphorylated H2AX (γ-H2AX) occurs around the break site. H2AX foci accumulate in early G2. Immunolocalization studies in spread preparations of wild-type meiocytes at G2/early leptotene revealed the accumulation of numerous rather diffuse γ-H2AX foci throughout the chromatin. However, their accumulation is not contemporaneous with that of AtSPO11-1. At 3 h post-S, no γ-H2AX foci are detected. During the 3- to 5-h window when AtSPO11-1 foci rapidly disappear, there is an equally swift accumulation of γ-H2AX to a maximum of >50 diffuse foci. The level of γH2AX then remains constant for a further 13 h before undergoing a gradual decrease to 10ñ20 foci in the 18- to 24-h post-S period. By 30 h the foci have disappeared from the chromatin.; gamma histone variant H2AX (GAMMA-H2AX); FUNCTIONS IN: DNA binding; INVOLVED IN: nucleosome assembly; LOCATED IN: nucleolus, nucleus; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Histone H2A (InterPro:IPR002119), Histone-fold (InterPro:IPR009072), Histone core (InterPro:IPR007125); BEST Arabidopsis thaliana protein match is: Histone superfamily protein (TAIR:AT1G08880.1); Has 3932 Blast hits to 3927 proteins in 364 species: Archae - 0; Bacteria - 0; Metazoa - 2549; Fungi - 335; Plants - 612; Viruses - 4; Other Eukaryotes - 432 (source: NCBI BLink). & (reliability: 404.0) & (original description: no original description)
Gene families : OG_42_0000138 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000138_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | Pseudotsuga release: PSME_00052764-RA | |
Cluster | HCCA clusters: Cluster_70 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
At1g08880 | No alias | Histone H2A [Source:UniProtKB/TrEMBL;Acc:A0A178W8H7] | 0.02 | Orthogroups_2024-Update | |
At1g51060 | No alias | Probable histone H2A.1 [Source:UniProtKB/Swiss-Prot;Acc:Q9C681] | 0.02 | Orthogroups_2024-Update | |
Bradi2g23090 | No alias | histone H2A 12 | 0.04 | Orthogroups_2024-Update | |
Brara.B03550.1 | No alias | histone *(H2A) | 0.02 | Orthogroups_2024-Update | |
Brara.E02150.1 | No alias | histone *(H2A) | 0.03 | Orthogroups_2024-Update | |
LOC_Os03g17100 | No alias | Core histone H2A/H2B/H3/H4 domain containing protein,... | 0.02 | Orthogroups_2024-Update | |
MA_924620g0010 | No alias | (q2hu68|h2a1_medtr : 180.0) Probable histone H2A.1 -... | 0.03 | Orthogroups_2024-Update | |
PSME_00017670-RA | No alias | (p35063|h2ax_picab : 188.0) Histone H2AX - Picea abies... | 0.05 | Orthogroups_2024-Update |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
CC | GO:0000786 | nucleosome | IEA | InterProScan predictions |
MF | GO:0003677 | DNA binding | IEA | InterProScan predictions |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
BP | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | IEP | Predicted GO |
CC | GO:0005783 | endoplasmic reticulum | IEP | Predicted GO |
BP | GO:0006364 | rRNA processing | IEP | Predicted GO |
BP | GO:0006457 | protein folding | IEP | Predicted GO |
BP | GO:0016072 | rRNA metabolic process | IEP | Predicted GO |
BP | GO:0030490 | maturation of SSU-rRNA | IEP | Predicted GO |
MF | GO:0030515 | snoRNA binding | IEP | Predicted GO |
BP | GO:0034470 | ncRNA processing | IEP | Predicted GO |
MF | GO:0051082 | unfolded protein binding | IEP | Predicted GO |
No external refs found! |