Description : (at1g48050 : 87.8) Ku80 and ku70 form the heterodimer complex Ku, required for proper maintenance of the telomeric C strand. Ku regulates the extension of the telomeric G strand. Interacts with WEX, and this interaction stimulates the WEX exonuclease activity. Binds double stranded DNA breaks as a heterodimer with Ku70, involved in non-homologous end joining repair. Mutants are defective in T-DNA integration. Over expression confers increased resistance to DNA damage agents and increased susceptibility to T-DNA transformation.; KU80; FUNCTIONS IN: double-stranded DNA binding, protein binding; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ku70/Ku80, N-terminal alpha/beta (InterPro:IPR005161), DNA helicase, ATP-dependent, Ku type (InterPro:IPR006164), Spen Paralogue and Orthologue SPOC, C-terminal-like (InterPro:IPR016194), Ku70/Ku80 C-terminal arm (InterPro:IPR005160), Ku, C-terminal (InterPro:IPR014893); Has 786 Blast hits to 750 proteins in 217 species: Archae - 0; Bacteria - 40; Metazoa - 246; Fungi - 345; Plants - 62; Viruses - 0; Other Eukaryotes - 93 (source: NCBI BLink). & (reliability: 175.6) & (original description: no original description)
Gene families : OG_42_0001893 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001893_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | Pseudotsuga release: PSME_00054000-RA | |
Cluster | HCCA clusters: Cluster_61 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
At1g48050 | No alias | ATP-dependent DNA helicase 2 subunit KU80... | 0.03 | Orthogroups_2024-Update | |
PSME_00031675-RA | No alias | (at1g48050 : 94.7) Ku80 and ku70 form the heterodimer... | 0.04 | Orthogroups_2024-Update | |
PSME_00042437-RA | No alias | no hits & (original description: no original description) | 0.02 | Orthogroups_2024-Update |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No GO annotation available for this sequence |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
CC | GO:0005741 | mitochondrial outer membrane | IEP | Predicted GO |
CC | GO:0031225 | anchored component of membrane | IEP | Predicted GO |
CC | GO:0031226 | intrinsic component of plasma membrane | IEP | Predicted GO |
CC | GO:0031968 | organelle outer membrane | IEP | Predicted GO |
CC | GO:0046658 | anchored component of plasma membrane | IEP | Predicted GO |
MF | GO:0046983 | protein dimerization activity | IEP | Predicted GO |
CC | GO:0098805 | whole membrane | IEP | Predicted GO |
No InterPro domains available for this sequence
No external refs found! |