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GO:0016592: mediator complex (Cellular component)

"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]


There are 7768 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_191 Solanum lycopersicum 2.02 % 0.00244 0.034572
Cluster_168 Chlamydomonas reinhardtii 4.08 % 0.000111 0.000742
Cluster_142 Klebsormidium nitens 50.0 % 0.001388 0.022211
Cluster_1 Picea abies 0.97 % 0.000182 0.008272
Cluster_91 Porphyridium purpureum 50.0 % 0.002632 0.047368
Cluster_13 Selaginella moellendorffii 1.89 % 2e-06 0.000246
Cluster_121 Pseudotsuga menziesii 2.63 % 0.000288 0.003321
Cluster_169 Glycine max 1.05 % 0.003945 0.03308
Cluster_224 Zea mays 3.85 % 0.00015 0.029035
cluster_0076 Oryza sativa 0.74 % 2.4e-05 0.001874
Cluster_167 Sorghum bicolor 2.83 % 1.9e-05 0.001918
Cluster_76 Setaria italica 2.68 % 9e-06 0.00266
Sequences (7768) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro and Family associations disabled for items with more than 5000 associated sequences !