Description : (at1g50240 : 182.0) The FUSED (FU) gene belongs to Ser/Thr protein kinase family and has a key role in the hedgehog signaling pathway known to control cell proliferation and patterning in fruit flies and humans . Arabidopsis thaliana genome has a single Fu gene. Cytokinesis-defective mutants, which we named two-in-one (tio), result from mutations in Arabidopsis Fu. Phenotypic analysis of tio mutants reveals an essential role for TIO in conventional modes of cytokinesis in plant meristems and during male gametogenesis. TIO is tightly localized to the midline of the nascent phragmoplast and remains associated with the expanding phragmoplast ring. This gene was previously annotated as two gene models, AT1G50230.1 and AT1G50240.1, however the experimental evidence exists (Oh et al, Current Biology, 2005) showing that these two models are in fact single gene, named FUSED.; FUSED (FU); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), 26S proteasome non-ATPase regulatory subunit 5 (InterPro:IPR019538), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: serine/threonine protein kinase 2 (TAIR:AT3G08720.2); Has 138334 Blast hits to 135590 proteins in 4834 species: Archae - 164; Bacteria - 15793; Metazoa - 51363; Fungi - 13983; Plants - 33508; Viruses - 544; Other Eukaryotes - 22979 (source: NCBI BLink). & (reliability: 364.0) & (original description: no original description)
Condition specificity: 11 h after light (SPM: 0.44, entropy: 3.25, tau: 0.41)