Description : (at5g04560 : 155.0) Encodes a DNA glycosylase DEMETER (DME). Responsible for endosperm maternal-allele-specific hypomethylation at the MEDEA (MEA) gene. DME can excise 5-methylcytosine in vitro and when expressed in E. coli. DME establishes MEA imprinting by removing 5-methylcytosine to activate the maternal allele.; DEMETER (DME); CONTAINS InterPro DOMAIN/s: DNA glycosylase (InterPro:IPR011257), Endonuclease III-like, iron-sulphur cluster loop motif (InterPro:IPR003651), HhH-GPD domain (InterPro:IPR003265); BEST Arabidopsis thaliana protein match is: demeter-like 1 (TAIR:AT2G36490.1); Has 3806 Blast hits to 3649 proteins in 1364 species: Archae - 237; Bacteria - 2338; Metazoa - 256; Fungi - 124; Plants - 347; Viruses - 0; Other Eukaryotes - 504 (source: NCBI BLink). & (reliability: 294.0) & (original description: no original description)
Condition specificity: 13 h after light (SPM: 0.34, entropy: 2.69, tau: 0.18)