Description : (q01559|hmdh_nicsy : 220.0) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase) - Nicotiana sylvestris (Wood tobacco) & (at1g76490 : 216.0) Encodes a 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is involved in melavonate biosynthesis and performs the first committed step in isoprenoid biosynthesis. Expression is activated in dark in leaf tissue but not controlled by light in the root (confine; hydroxy methylglutaryl CoA reductase 1 (HMG1); CONTAINS InterPro DOMAIN/s: Hydroxymethylglutaryl-CoA reductase, class I, catalytic (InterPro:IPR004554), Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding (InterPro:IPR009029), Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding (InterPro:IPR009023), Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic (InterPro:IPR002202); BEST Arabidopsis thaliana protein match is: 3-hydroxy-3-methylglutaryl-CoA reductase 2 (TAIR:AT2G17370.1); Has 2212 Blast hits to 2210 proteins in 935 species: Archae - 202; Bacteria - 1018; Metazoa - 225; Fungi - 225; Plants - 266; Viruses - 1; Other Eukaryotes - 275 (source: NCBI BLink). & (reliability: 432.0) & (original description: no original description)
Condition specificity: 7 h after dark (SPM: 0.59, entropy: 3.42, tau: 0.64)