MA_6556803g0010

Description : (q01559|hmdh_nicsy : 220.0) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase) - Nicotiana sylvestris (Wood tobacco) & (at1g76490 : 216.0) Encodes a 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is involved in melavonate biosynthesis and performs the first committed step in isoprenoid biosynthesis. Expression is activated in dark in leaf tissue but not controlled by light in the root (confine; hydroxy methylglutaryl CoA reductase 1 (HMG1); CONTAINS InterPro DOMAIN/s: Hydroxymethylglutaryl-CoA reductase, class I, catalytic (InterPro:IPR004554), Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding (InterPro:IPR009029), Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding (InterPro:IPR009023), Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic (InterPro:IPR002202); BEST Arabidopsis thaliana protein match is: 3-hydroxy-3-methylglutaryl-CoA reductase 2 (TAIR:AT2G17370.1); Has 2212 Blast hits to 2210 proteins in 935 species: Archae - 202; Bacteria - 1018; Metazoa - 225; Fungi - 225; Plants - 266; Viruses - 1; Other Eukaryotes - 275 (source: NCBI BLink). & (reliability: 432.0) & (original description: no original description)

Gene families : OG_42_0001334 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001334_tree

Sequence : coding (download), protein (download)

Attention: This gene has low abundance.

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Picea release: MA_6556803g0010
Cluster	HCCA clusters: Cluster_95

Target	Alias	Description	ECC score	Gene Family Method
LOC_Os02g48330	No alias	3-hydroxy-3-methylglutaryl-coenzyme A reductase,...	0.02	Orthogroups_2024-Update
LOC_Os08g40180	No alias	3-hydroxy-3-methylglutaryl-coenzyme A reductase,...	0.03	Orthogroups_2024-Update
PSME_00003399-RA	No alias	(q01559\|hmdh_nicsy : 734.0)...	0.03	Orthogroups_2024-Update
PSME_00003404-RA	No alias	(p48020\|hmdh1_soltu : 749.0)...	0.05	Orthogroups_2024-Update
Potri.001G457000	No alias	hydroxy methylglutaryl CoA reductase 1	0.03	Orthogroups_2024-Update
Potri.009G169900	No alias	hydroxy methylglutaryl CoA reductase 1	0.03	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006163	purine nucleotide metabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006732	coenzyme metabolic process	None	Extended
BP	GO:0006753	nucleoside phosphate metabolic process	None	Extended
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009117	nucleotide metabolic process	None	Extended
BP	GO:0009150	purine ribonucleotide metabolic process	None	Extended
BP	GO:0009259	ribonucleotide metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0015936	coenzyme A metabolic process	IEA	InterProScan predictions
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	None	Extended
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	None	Extended
BP	GO:0019637	organophosphate metabolic process	None	Extended
BP	GO:0019693	ribose phosphate metabolic process	None	Extended
BP	GO:0033865	nucleoside bisphosphate metabolic process	None	Extended
BP	GO:0033875	ribonucleoside bisphosphate metabolic process	None	Extended
BP	GO:0034032	purine nucleoside bisphosphate metabolic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
MF	GO:0048037	cofactor binding	None	Extended
MF	GO:0050662	coenzyme binding	IEA	InterProScan predictions
BP	GO:0051186	cofactor metabolic process	None	Extended
BP	GO:0055086	nucleobase-containing small molecule metabolic process	None	Extended
BP	GO:0055114	oxidation-reduction process	IEA	InterProScan predictions
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0072521	purine-containing compound metabolic process	None	Extended
BP	GO:1901135	carbohydrate derivative metabolic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0003677	DNA binding	IEP	Predicted GO
MF	GO:0004611	phosphoenolpyruvate carboxykinase activity	IEP	Predicted GO
MF	GO:0005102	signaling receptor binding	IEP	Predicted GO
MF	GO:0005215	transporter activity	IEP	Predicted GO
BP	GO:0006099	tricarboxylic acid cycle	IEP	Predicted GO
BP	GO:0006101	citrate metabolic process	IEP	Predicted GO
BP	GO:0006355	regulation of transcription, DNA-templated	IEP	Predicted GO
BP	GO:0006855	drug transmembrane transport	IEP	Predicted GO
MF	GO:0008083	growth factor activity	IEP	Predicted GO
BP	GO:0008283	cell proliferation	IEP	Predicted GO
MF	GO:0008519	ammonium transmembrane transporter activity	IEP	Predicted GO
MF	GO:0008964	phosphoenolpyruvate carboxylase activity	IEP	Predicted GO
BP	GO:0009889	regulation of biosynthetic process	IEP	Predicted GO
BP	GO:0010468	regulation of gene expression	IEP	Predicted GO
BP	GO:0010556	regulation of macromolecule biosynthetic process	IEP	Predicted GO
MF	GO:0015238	drug transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015291	secondary active transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015297	antiporter activity	IEP	Predicted GO
BP	GO:0015696	ammonium transport	IEP	Predicted GO
BP	GO:0015893	drug transport	IEP	Predicted GO
BP	GO:0015977	carbon fixation	IEP	Predicted GO
CC	GO:0016020	membrane	IEP	Predicted GO
MF	GO:0016831	carboxy-lyase activity	IEP	Predicted GO
BP	GO:0016999	antibiotic metabolic process	IEP	Predicted GO
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0019222	regulation of metabolic process	IEP	Predicted GO
MF	GO:0022804	active transmembrane transporter activity	IEP	Predicted GO
MF	GO:0022857	transmembrane transporter activity	IEP	Predicted GO
MF	GO:0030545	receptor regulator activity	IEP	Predicted GO
BP	GO:0031323	regulation of cellular metabolic process	IEP	Predicted GO
BP	GO:0031326	regulation of cellular biosynthetic process	IEP	Predicted GO
MF	GO:0043565	sequence-specific DNA binding	IEP	Predicted GO
MF	GO:0048018	receptor ligand activity	IEP	Predicted GO
BP	GO:0051171	regulation of nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0051252	regulation of RNA metabolic process	IEP	Predicted GO
BP	GO:0060255	regulation of macromolecule metabolic process	IEP	Predicted GO
BP	GO:0072350	tricarboxylic acid metabolic process	IEP	Predicted GO
BP	GO:0080090	regulation of primary metabolic process	IEP	Predicted GO
BP	GO:1903506	regulation of nucleic acid-templated transcription	IEP	Predicted GO
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:2001141	regulation of RNA biosynthetic process	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR002202	HMG_CoA_Rdtase	4	140

External Links

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MA_6556803g0010

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation