evm.model.tig00000215.116

Description : (at1g47290 : 240.0) Encodes an enzyme with 3β-hydroxysteroid dehydrogenase/C4-decarboxylase activity <i>in vitro</i>. The activity of the enzyme was determined using microsomal extracts of yeast overexpressing the <i>Arabidopsis</i> gene. Cytosolic fractions failed to be associated to the activity, leading to the speculation that the enzyme is membrane-bound.; 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1 (3BETAHSD/D1); FUNCTIONS IN: 3-beta-hydroxy-delta5-steroid dehydrogenase activity, sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; INVOLVED IN: steroid biosynthetic process, metabolic process; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040), 3-beta hydroxysteroid dehydrogenase/isomerase (InterPro:IPR002225); BEST Arabidopsis thaliana protein match is: 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2 (TAIR:AT2G26260.1); Has 24445 Blast hits to 24432 proteins in 2873 species: Archae - 619; Bacteria - 15430; Metazoa - 691; Fungi - 529; Plants - 1560; Viruses - 132; Other Eukaryotes - 5484 (source: NCBI BLink). & (reliability: 480.0) & (original description: no original description)

Gene families : OG_42_0001400 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001400_tree

Sequence : coding (download), protein (download)

Download

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Cyanophora release: evm.model.tig00000215.116
Cluster	HCCA clusters: Cluster_23

Target	Alias	Description	ECC score	Gene Family Method
PSME_00001766-RA	No alias	(at2g26260 : 240.0) Encodes an enzyme with...	0.02	Orthogroups_2024-Update
evm.model.contig_2199.4	No alias	(at1g47290 : 151.0) Encodes an enzyme with...	0.01	Orthogroups_2024-Update
evm.model.contig_452.11	No alias	(at1g47290 : 123.0) Encodes an enzyme with...	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	IEA	InterProScan predictions
BP	GO:0006629	lipid metabolic process	None	Extended
BP	GO:0006694	steroid biosynthetic process	IEA	InterProScan predictions
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0008202	steroid metabolic process	None	Extended
BP	GO:0008610	lipid biosynthetic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
MF	GO:0016229	steroid dehydrogenase activity	None	Extended
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	None	Extended
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA	InterProScan predictions
MF	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0055114	oxidation-reduction process	IEA	InterProScan predictions
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901362	organic cyclic compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
MF	GO:0004177	aminopeptidase activity	IEP	Predicted GO
MF	GO:0004190	aspartic-type endopeptidase activity	IEP	Predicted GO
MF	GO:0004427	inorganic diphosphatase activity	IEP	Predicted GO
MF	GO:0004618	phosphoglycerate kinase activity	IEP	Predicted GO
MF	GO:0004751	ribose-5-phosphate isomerase activity	IEP	Predicted GO
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004832	valine-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004853	uroporphyrinogen decarboxylase activity	IEP	Predicted GO
MF	GO:0005261	cation channel activity	IEP	Predicted GO
CC	GO:0005622	intracellular	IEP	Predicted GO
CC	GO:0005737	cytoplasm	IEP	Predicted GO
BP	GO:0006081	cellular aldehyde metabolic process	IEP	Predicted GO
BP	GO:0006082	organic acid metabolic process	IEP	Predicted GO
BP	GO:0006399	tRNA metabolic process	IEP	Predicted GO
BP	GO:0006417	regulation of translation	IEP	Predicted GO
BP	GO:0006418	tRNA aminoacylation for protein translation	IEP	Predicted GO
BP	GO:0006438	valyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006446	regulation of translational initiation	IEP	Predicted GO
BP	GO:0006520	cellular amino acid metabolic process	IEP	Predicted GO
BP	GO:0006553	lysine metabolic process	IEP	Predicted GO
BP	GO:0006720	isoprenoid metabolic process	IEP	Predicted GO
BP	GO:0006721	terpenoid metabolic process	IEP	Predicted GO
BP	GO:0006725	cellular aromatic compound metabolic process	IEP	Predicted GO
BP	GO:0006778	porphyrin-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006779	porphyrin-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0006807	nitrogen compound metabolic process	IEP	Predicted GO
MF	GO:0008144	drug binding	IEP	Predicted GO
MF	GO:0008190	eukaryotic initiation factor 4E binding	IEP	Predicted GO
MF	GO:0008238	exopeptidase activity	IEP	Predicted GO
BP	GO:0008299	isoprenoid biosynthetic process	IEP	Predicted GO
MF	GO:0008483	transaminase activity	IEP	Predicted GO
MF	GO:0008837	diaminopimelate epimerase activity	IEP	Predicted GO
BP	GO:0009052	pentose-phosphate shunt, non-oxidative branch	IEP	Predicted GO
BP	GO:0009066	aspartate family amino acid metabolic process	IEP	Predicted GO
BP	GO:0009067	aspartate family amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009085	lysine biosynthetic process	IEP	Predicted GO
BP	GO:0009089	lysine biosynthetic process via diaminopimelate	IEP	Predicted GO
BP	GO:0009890	negative regulation of biosynthetic process	IEP	Predicted GO
BP	GO:0009892	negative regulation of metabolic process	IEP	Predicted GO
BP	GO:0009987	cellular process	IEP	Predicted GO
BP	GO:0010558	negative regulation of macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0010605	negative regulation of macromolecule metabolic process	IEP	Predicted GO
BP	GO:0010608	posttranscriptional regulation of gene expression	IEP	Predicted GO
BP	GO:0010629	negative regulation of gene expression	IEP	Predicted GO
BP	GO:0016053	organic acid biosynthetic process	IEP	Predicted GO
BP	GO:0016070	RNA metabolic process	IEP	Predicted GO
BP	GO:0016114	terpenoid biosynthetic process	IEP	Predicted GO
MF	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	IEP	Predicted GO
MF	GO:0016769	transferase activity, transferring nitrogenous groups	IEP	Predicted GO
MF	GO:0016774	phosphotransferase activity, carboxyl group as acceptor	IEP	Predicted GO
MF	GO:0016831	carboxy-lyase activity	IEP	Predicted GO
MF	GO:0016853	isomerase activity	IEP	Predicted GO
MF	GO:0016854	racemase and epimerase activity	IEP	Predicted GO
MF	GO:0016855	racemase and epimerase activity, acting on amino acids and derivatives	IEP	Predicted GO
MF	GO:0016860	intramolecular oxidoreductase activity	IEP	Predicted GO
MF	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	IEP	Predicted GO
MF	GO:0016868	intramolecular transferase activity, phosphotransferases	IEP	Predicted GO
MF	GO:0016874	ligase activity	IEP	Predicted GO
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	IEP	Predicted GO
MF	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	IEP	Predicted GO
BP	GO:0017006	protein-tetrapyrrole linkage	IEP	Predicted GO
BP	GO:0017007	protein-bilin linkage	IEP	Predicted GO
BP	GO:0017009	protein-phycocyanobilin linkage	IEP	Predicted GO
BP	GO:0017148	negative regulation of translation	IEP	Predicted GO
BP	GO:0019682	glyceraldehyde-3-phosphate metabolic process	IEP	Predicted GO
BP	GO:0019693	ribose phosphate metabolic process	IEP	Predicted GO
BP	GO:0019752	carboxylic acid metabolic process	IEP	Predicted GO
CC	GO:0030076	light-harvesting complex	IEP	Predicted GO
CC	GO:0030089	phycobilisome	IEP	Predicted GO
BP	GO:0031324	negative regulation of cellular metabolic process	IEP	Predicted GO
BP	GO:0031327	negative regulation of cellular biosynthetic process	IEP	Predicted GO
MF	GO:0031369	translation initiation factor binding	IEP	Predicted GO
BP	GO:0032268	regulation of cellular protein metabolic process	IEP	Predicted GO
BP	GO:0032269	negative regulation of cellular protein metabolic process	IEP	Predicted GO
BP	GO:0034248	regulation of cellular amide metabolic process	IEP	Predicted GO
BP	GO:0034249	negative regulation of cellular amide metabolic process	IEP	Predicted GO
BP	GO:0034660	ncRNA metabolic process	IEP	Predicted GO
MF	GO:0036094	small molecule binding	IEP	Predicted GO
MF	GO:0036361	racemase activity, acting on amino acids and derivatives	IEP	Predicted GO
BP	GO:0043038	amino acid activation	IEP	Predicted GO
BP	GO:0043039	tRNA aminoacylation	IEP	Predicted GO
MF	GO:0043168	anion binding	IEP	Predicted GO
BP	GO:0043436	oxoacid metabolic process	IEP	Predicted GO
BP	GO:0043648	dicarboxylic acid metabolic process	IEP	Predicted GO
BP	GO:0044237	cellular metabolic process	IEP	Predicted GO
BP	GO:0044281	small molecule metabolic process	IEP	Predicted GO
BP	GO:0044283	small molecule biosynthetic process	IEP	Predicted GO
BP	GO:0045947	negative regulation of translational initiation	IEP	Predicted GO
BP	GO:0046394	carboxylic acid biosynthetic process	IEP	Predicted GO
MF	GO:0046429	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity	IEP	Predicted GO
BP	GO:0046451	diaminopimelate metabolic process	IEP	Predicted GO
BP	GO:0046483	heterocycle metabolic process	IEP	Predicted GO
MF	GO:0047661	amino-acid racemase activity	IEP	Predicted GO
MF	GO:0048037	cofactor binding	IEP	Predicted GO
BP	GO:0051172	negative regulation of nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0051186	cofactor metabolic process	IEP	Predicted GO
BP	GO:0051188	cofactor biosynthetic process	IEP	Predicted GO
BP	GO:0051246	regulation of protein metabolic process	IEP	Predicted GO
BP	GO:0051248	negative regulation of protein metabolic process	IEP	Predicted GO
MF	GO:0052592	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor	IEP	Predicted GO
MF	GO:0070001	aspartic-type peptidase activity	IEP	Predicted GO
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	IEP	Predicted GO
MF	GO:0070569	uridylyltransferase activity	IEP	Predicted GO
MF	GO:0071949	FAD binding	IEP	Predicted GO
MF	GO:0140098	catalytic activity, acting on RNA	IEP	Predicted GO
MF	GO:0140101	catalytic activity, acting on a tRNA	IEP	Predicted GO
BP	GO:1901135	carbohydrate derivative metabolic process	IEP	Predicted GO
BP	GO:1901564	organonitrogen compound metabolic process	IEP	Predicted GO
BP	GO:1901566	organonitrogen compound biosynthetic process	IEP	Predicted GO
BP	GO:2000113	negative regulation of cellular macromolecule biosynthetic process	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR002225	3Beta_OHSteriod_DH/Estase	8	272

External Links

No external refs found!

evm.model.tig00000215.116

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation