evm.model.tig00000241.38

Description : (at4g02060 : 657.0) Member of the minichromosome maintenance complex, involved in DNA replication initiation. Abundant in proliferating and endocycling tissues. Localized in the nucleus during G1, S and G2 phases of the cell cycle, and are released into the cytoplasmic compartment during mitosis. Binds chromatin.; PROLIFERA (PRL); CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), ATPase, AAA+ type, core (InterPro:IPR003593), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 7 (InterPro:IPR008050); BEST Arabidopsis thaliana protein match is: minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT5G44635.1). & (q43704|mcm3_maize : 291.0) DNA replication licensing factor MCM3 homolog (Replication origin activator) (ROA protein) (Fragment) - Zea mays (Maize) & (reliability: 1314.0) & (original description: no original description)

Gene families : OG_42_0006411 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0006411_tree

Sequence : coding (download), protein (download)

Download

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Cyanophora release: evm.model.tig00000241.38
Cluster	HCCA clusters: Cluster_54

Target	Alias	Description	ECC score	Gene Family Method
At4g02060	No alias	DNA replication licensing factor MCM7...	0.04	Orthogroups_2024-Update
Bradi4g04730	No alias	Minichromosome maintenance (MCM2/3/5) family protein	0.03	Orthogroups_2024-Update
Brara.C02829.1	No alias	component *(MCM7) of MCM replicative DNA helicase complex	0.06	Orthogroups_2024-Update
Brara.I00125.1	No alias	component *(MCM7) of MCM replicative DNA helicase complex	0.06	Orthogroups_2024-Update
Cre10.g455850	No alias	Minichromosome maintenance (MCM2/3/5) family protein	0.08	Orthogroups_2024-Update
Glyma.03G219200	No alias	Minichromosome maintenance (MCM2/3/5) family protein	0.07	Orthogroups_2024-Update
Glyma.19G216100	No alias	Minichromosome maintenance (MCM2/3/5) family protein	0.05	Orthogroups_2024-Update
Kfl00481_0090	kfl00481_0090_v1.1	(at4g02060 : 837.0) Member of the minichromosome...	0.07	Orthogroups_2024-Update
MA_10426237g0010	No alias	(at4g02060 : 1090.0) Member of the minichromosome...	0.03	Orthogroups_2024-Update
Mp2g02600.1	No alias	component MCM7 of MCM replicative DNA helicase complex	0.02	Orthogroups_2024-Update
PSME_00006615-RA	No alias	(at4g02060 : 612.0) Member of the minichromosome...	0.02	Orthogroups_2024-Update
Potri.014G121000	No alias	Minichromosome maintenance (MCM2/3/5) family protein	0.01	Orthogroups_2024-Update
Seita.3G335500.1	No alias	component *(MCM7) of MCM replicative DNA helicase complex	0.09	Orthogroups_2024-Update
Sobic.008G129200.1	No alias	component *(MCM7) of MCM replicative DNA helicase complex	0.08	Orthogroups_2024-Update
Solyc01g079500	No alias	Vps51/Vps67 family (components of vesicular transport)...	0.07	Orthogroups_2024-Update
Sopen01g031270	No alias	MCM2/3/5 family	0.05	Orthogroups_2024-Update
evm.model.contig_490.1	No alias	(at4g02060 : 555.0) Member of the minichromosome...	0.07	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	InterProScan predictions
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006270	DNA replication initiation	IEA	InterProScan predictions
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
MF	GO:0003689	DNA clamp loader activity	IEP	Predicted GO
MF	GO:0003896	DNA primase activity	IEP	Predicted GO
MF	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	IEP	Predicted GO
MF	GO:0005515	protein binding	IEP	Predicted GO
CC	GO:0005634	nucleus	IEP	Predicted GO
CC	GO:0005663	DNA replication factor C complex	IEP	Predicted GO
CC	GO:0005694	chromosome	IEP	Predicted GO
BP	GO:0006220	pyrimidine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0006221	pyrimidine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0006231	dTMP biosynthetic process	IEP	Predicted GO
BP	GO:0006260	DNA replication	IEP	Predicted GO
BP	GO:0006269	DNA replication, synthesis of RNA primer	IEP	Predicted GO
BP	GO:0006275	regulation of DNA replication	IEP	Predicted GO
BP	GO:0006298	mismatch repair	IEP	Predicted GO
BP	GO:0006996	organelle organization	IEP	Predicted GO
MF	GO:0008094	DNA-dependent ATPase activity	IEP	Predicted GO
BP	GO:0009058	biosynthetic process	IEP	Predicted GO
BP	GO:0009059	macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0009129	pyrimidine nucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009130	pyrimidine nucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009162	deoxyribonucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009176	pyrimidine deoxyribonucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009177	pyrimidine deoxyribonucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009219	pyrimidine deoxyribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009221	pyrimidine deoxyribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009262	deoxyribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009263	deoxyribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009265	2'-deoxyribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009394	2'-deoxyribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0010564	regulation of cell cycle process	IEP	Predicted GO
BP	GO:0010639	negative regulation of organelle organization	IEP	Predicted GO
MF	GO:0016779	nucleotidyltransferase activity	IEP	Predicted GO
BP	GO:0019692	deoxyribose phosphate metabolic process	IEP	Predicted GO
MF	GO:0030983	mismatched DNA binding	IEP	Predicted GO
MF	GO:0031625	ubiquitin protein ligase binding	IEP	Predicted GO
BP	GO:0032465	regulation of cytokinesis	IEP	Predicted GO
BP	GO:0032774	RNA biosynthetic process	IEP	Predicted GO
BP	GO:0032954	regulation of cytokinetic process	IEP	Predicted GO
BP	GO:0032955	regulation of division septum assembly	IEP	Predicted GO
BP	GO:0033043	regulation of organelle organization	IEP	Predicted GO
BP	GO:0033044	regulation of chromosome organization	IEP	Predicted GO
MF	GO:0033170	protein-DNA loading ATPase activity	IEP	Predicted GO
MF	GO:0034062	5'-3' RNA polymerase activity	IEP	Predicted GO
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Predicted GO
MF	GO:0042083	5,10-methylenetetrahydrofolate-dependent methyltransferase activity	IEP	Predicted GO
CC	GO:0042555	MCM complex	IEP	Predicted GO
BP	GO:0043086	negative regulation of catalytic activity	IEP	Predicted GO
CC	GO:0043226	organelle	IEP	Predicted GO
CC	GO:0043228	non-membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043229	intracellular organelle	IEP	Predicted GO
CC	GO:0043232	intracellular non-membrane-bounded organelle	IEP	Predicted GO
BP	GO:0044087	regulation of cellular component biogenesis	IEP	Predicted GO
BP	GO:0044092	negative regulation of molecular function	IEP	Predicted GO
BP	GO:0044249	cellular biosynthetic process	IEP	Predicted GO
MF	GO:0044389	ubiquitin-like protein ligase binding	IEP	Predicted GO
CC	GO:0044424	intracellular part	IEP	Predicted GO
CC	GO:0044464	cell part	IEP	Predicted GO
BP	GO:0046073	dTMP metabolic process	IEP	Predicted GO
BP	GO:0046385	deoxyribose phosphate biosynthetic process	IEP	Predicted GO
BP	GO:0050790	regulation of catalytic activity	IEP	Predicted GO
MF	GO:0050797	thymidylate synthase (FAD) activity	IEP	Predicted GO
BP	GO:0051052	regulation of DNA metabolic process	IEP	Predicted GO
BP	GO:0051095	regulation of helicase activity	IEP	Predicted GO
BP	GO:0051097	negative regulation of helicase activity	IEP	Predicted GO
BP	GO:0051128	regulation of cellular component organization	IEP	Predicted GO
BP	GO:0051129	negative regulation of cellular component organization	IEP	Predicted GO
BP	GO:0051276	chromosome organization	IEP	Predicted GO
BP	GO:0051301	cell division	IEP	Predicted GO
BP	GO:0051302	regulation of cell division	IEP	Predicted GO
BP	GO:0051336	regulation of hydrolase activity	IEP	Predicted GO
BP	GO:0051346	negative regulation of hydrolase activity	IEP	Predicted GO
BP	GO:0065009	regulation of molecular function	IEP	Predicted GO
BP	GO:0072527	pyrimidine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072528	pyrimidine-containing compound biosynthetic process	IEP	Predicted GO
MF	GO:0097747	RNA polymerase activity	IEP	Predicted GO
BP	GO:1901576	organic substance biosynthetic process	IEP	Predicted GO
BP	GO:1901891	regulation of cell septum assembly	IEP	Predicted GO
BP	GO:1905462	regulation of DNA duplex unwinding	IEP	Predicted GO
BP	GO:1905463	negative regulation of DNA duplex unwinding	IEP	Predicted GO
BP	GO:1905774	regulation of DNA helicase activity	IEP	Predicted GO
BP	GO:1905775	negative regulation of DNA helicase activity	IEP	Predicted GO
BP	GO:2001251	negative regulation of chromosome organization	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR001208	MCM_dom	323	544
IPR027925	MCM_N	17	144
IPR033762	MCM_OB	153	283

External Links

No external refs found!

evm.model.tig00000241.38

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation