evm.model.tig00001302.6

Description : (at3g25100 : 125.0) Required for normal meiosis, may act in the last round of DNA replication prior to meiosis, sequence similar to yeast CDC45; cell division cycle 45 (CDC45); CONTAINS InterPro DOMAIN/s: CDC45-like protein (InterPro:IPR003874); Has 1810 Blast hits to 1657 proteins in 252 species: Archae - 0; Bacteria - 25; Metazoa - 666; Fungi - 449; Plants - 176; Viruses - 35; Other Eukaryotes - 459 (source: NCBI BLink). & (reliability: 250.0) & (original description: no original description)

Gene families : OG_42_0003159 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0003159_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Cyanophora release: evm.model.tig00001302.6
Cluster	HCCA clusters: Cluster_54

Target	Alias	Description	ECC score	Gene Family Method
Cre06.g270250	No alias	cell division cycle 45	0.03	Orthogroups_2024-Update
Kfl00349_0090	kfl00349_0090_v1.1	(at3g25100 : 380.0) Required for normal meiosis, may act...	0.06	Orthogroups_2024-Update
PSME_00020251-RA	No alias	(at3g25100 : 220.0) Required for normal meiosis, may act...	0.01	Orthogroups_2024-Update
PSME_00030284-RA	No alias	(at3g25100 : 129.0) Required for normal meiosis, may act...	0.01	Orthogroups_2024-Update
Sobic.008G020500.1	No alias	cell cycle auxiliary factor *(CDC45)	0.01	Orthogroups_2024-Update
evm.model.contig_2276.11	No alias	no hits & (original description: no original description)	0.03	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006270	DNA replication initiation	IEA	InterProScan predictions
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
CC	GO:0000151	ubiquitin ligase complex	IEP	Predicted GO
CC	GO:0000152	nuclear ubiquitin ligase complex	IEP	Predicted GO
MF	GO:0003676	nucleic acid binding	IEP	Predicted GO
MF	GO:0003677	DNA binding	IEP	Predicted GO
MF	GO:0003887	DNA-directed DNA polymerase activity	IEP	Predicted GO
MF	GO:0003896	DNA primase activity	IEP	Predicted GO
MF	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	IEP	Predicted GO
MF	GO:0003909	DNA ligase activity	IEP	Predicted GO
MF	GO:0003910	DNA ligase (ATP) activity	IEP	Predicted GO
MF	GO:0004797	thymidine kinase activity	IEP	Predicted GO
MF	GO:0005488	binding	IEP	Predicted GO
MF	GO:0005509	calcium ion binding	IEP	Predicted GO
CC	GO:0005575	cellular_component	IEP	Predicted GO
CC	GO:0005634	nucleus	IEP	Predicted GO
CC	GO:0005680	anaphase-promoting complex	IEP	Predicted GO
CC	GO:0005694	chromosome	IEP	Predicted GO
BP	GO:0006220	pyrimidine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0006221	pyrimidine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0006231	dTMP biosynthetic process	IEP	Predicted GO
BP	GO:0006260	DNA replication	IEP	Predicted GO
BP	GO:0006269	DNA replication, synthesis of RNA primer	IEP	Predicted GO
BP	GO:0006275	regulation of DNA replication	IEP	Predicted GO
BP	GO:0006281	DNA repair	IEP	Predicted GO
BP	GO:0006310	DNA recombination	IEP	Predicted GO
BP	GO:0006401	RNA catabolic process	IEP	Predicted GO
BP	GO:0006511	ubiquitin-dependent protein catabolic process	IEP	Predicted GO
BP	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	IEP	Predicted GO
BP	GO:0006950	response to stress	IEP	Predicted GO
BP	GO:0006974	cellular response to DNA damage stimulus	IEP	Predicted GO
BP	GO:0007088	regulation of mitotic nuclear division	IEP	Predicted GO
BP	GO:0007346	regulation of mitotic cell cycle	IEP	Predicted GO
BP	GO:0008156	negative regulation of DNA replication	IEP	Predicted GO
BP	GO:0009056	catabolic process	IEP	Predicted GO
BP	GO:0009057	macromolecule catabolic process	IEP	Predicted GO
BP	GO:0009058	biosynthetic process	IEP	Predicted GO
BP	GO:0009059	macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0009129	pyrimidine nucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009130	pyrimidine nucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009162	deoxyribonucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009176	pyrimidine deoxyribonucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009177	pyrimidine deoxyribonucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009219	pyrimidine deoxyribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009221	pyrimidine deoxyribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009262	deoxyribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009263	deoxyribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009265	2'-deoxyribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009394	2'-deoxyribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009889	regulation of biosynthetic process	IEP	Predicted GO
BP	GO:0009890	negative regulation of biosynthetic process	IEP	Predicted GO
BP	GO:0009892	negative regulation of metabolic process	IEP	Predicted GO
BP	GO:0010498	proteasomal protein catabolic process	IEP	Predicted GO
BP	GO:0010556	regulation of macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0010558	negative regulation of macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0010564	regulation of cell cycle process	IEP	Predicted GO
BP	GO:0010605	negative regulation of macromolecule metabolic process	IEP	Predicted GO
BP	GO:0010965	regulation of mitotic sister chromatid separation	IEP	Predicted GO
MF	GO:0016779	nucleotidyltransferase activity	IEP	Predicted GO
MF	GO:0016886	ligase activity, forming phosphoric ester bonds	IEP	Predicted GO
MF	GO:0019136	deoxynucleoside kinase activity	IEP	Predicted GO
MF	GO:0019205	nucleobase-containing compound kinase activity	IEP	Predicted GO
MF	GO:0019206	nucleoside kinase activity	IEP	Predicted GO
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0019222	regulation of metabolic process	IEP	Predicted GO
BP	GO:0019692	deoxyribose phosphate metabolic process	IEP	Predicted GO
BP	GO:0019941	modification-dependent protein catabolic process	IEP	Predicted GO
BP	GO:0030071	regulation of mitotic metaphase/anaphase transition	IEP	Predicted GO
BP	GO:0030163	protein catabolic process	IEP	Predicted GO
BP	GO:0031144	proteasome localization	IEP	Predicted GO
BP	GO:0031323	regulation of cellular metabolic process	IEP	Predicted GO
BP	GO:0031324	negative regulation of cellular metabolic process	IEP	Predicted GO
BP	GO:0031326	regulation of cellular biosynthetic process	IEP	Predicted GO
BP	GO:0031327	negative regulation of cellular biosynthetic process	IEP	Predicted GO
CC	GO:0031461	cullin-RING ubiquitin ligase complex	IEP	Predicted GO
BP	GO:0031503	protein-containing complex localization	IEP	Predicted GO
MF	GO:0031625	ubiquitin protein ligase binding	IEP	Predicted GO
CC	GO:0032299	ribonuclease H2 complex	IEP	Predicted GO
BP	GO:0032774	RNA biosynthetic process	IEP	Predicted GO
BP	GO:0033043	regulation of organelle organization	IEP	Predicted GO
BP	GO:0033044	regulation of chromosome organization	IEP	Predicted GO
BP	GO:0033045	regulation of sister chromatid segregation	IEP	Predicted GO
BP	GO:0033047	regulation of mitotic sister chromatid segregation	IEP	Predicted GO
BP	GO:0033554	cellular response to stress	IEP	Predicted GO
MF	GO:0034061	DNA polymerase activity	IEP	Predicted GO
MF	GO:0034062	5'-3' RNA polymerase activity	IEP	Predicted GO
BP	GO:0034613	cellular protein localization	IEP	Predicted GO
BP	GO:0034629	cellular protein-containing complex localization	IEP	Predicted GO
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Predicted GO
MF	GO:0042083	5,10-methylenetetrahydrofolate-dependent methyltransferase activity	IEP	Predicted GO
BP	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IEP	Predicted GO
CC	GO:0043226	organelle	IEP	Predicted GO
CC	GO:0043227	membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043229	intracellular organelle	IEP	Predicted GO
CC	GO:0043231	intracellular membrane-bounded organelle	IEP	Predicted GO
BP	GO:0043632	modification-dependent macromolecule catabolic process	IEP	Predicted GO
BP	GO:0044248	cellular catabolic process	IEP	Predicted GO
BP	GO:0044249	cellular biosynthetic process	IEP	Predicted GO
BP	GO:0044265	cellular macromolecule catabolic process	IEP	Predicted GO
MF	GO:0044389	ubiquitin-like protein ligase binding	IEP	Predicted GO
CC	GO:0044424	intracellular part	IEP	Predicted GO
CC	GO:0044464	cell part	IEP	Predicted GO
BP	GO:0045005	DNA-dependent DNA replication maintenance of fidelity	IEP	Predicted GO
BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0046073	dTMP metabolic process	IEP	Predicted GO
BP	GO:0046385	deoxyribose phosphate biosynthetic process	IEP	Predicted GO
BP	GO:0048478	replication fork protection	IEP	Predicted GO
MF	GO:0050797	thymidylate synthase (FAD) activity	IEP	Predicted GO
BP	GO:0050896	response to stimulus	IEP	Predicted GO
BP	GO:0051052	regulation of DNA metabolic process	IEP	Predicted GO
BP	GO:0051053	negative regulation of DNA metabolic process	IEP	Predicted GO
BP	GO:0051171	regulation of nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0051172	negative regulation of nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0051603	proteolysis involved in cellular protein catabolic process	IEP	Predicted GO
BP	GO:0051716	cellular response to stimulus	IEP	Predicted GO
BP	GO:0051726	regulation of cell cycle	IEP	Predicted GO
BP	GO:0051783	regulation of nuclear division	IEP	Predicted GO
BP	GO:0051983	regulation of chromosome segregation	IEP	Predicted GO
BP	GO:0060255	regulation of macromolecule metabolic process	IEP	Predicted GO
BP	GO:0070727	cellular macromolecule localization	IEP	Predicted GO
BP	GO:0071630	nuclear protein quality control by the ubiquitin-proteasome system	IEP	Predicted GO
BP	GO:0072527	pyrimidine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072528	pyrimidine-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0080090	regulation of primary metabolic process	IEP	Predicted GO
BP	GO:0090329	regulation of DNA-dependent DNA replication	IEP	Predicted GO
MF	GO:0097159	organic cyclic compound binding	IEP	Predicted GO
MF	GO:0097747	RNA polymerase activity	IEP	Predicted GO
MF	GO:0140097	catalytic activity, acting on DNA	IEP	Predicted GO
MF	GO:1901363	heterocyclic compound binding	IEP	Predicted GO
BP	GO:1901565	organonitrogen compound catabolic process	IEP	Predicted GO
BP	GO:1901575	organic substance catabolic process	IEP	Predicted GO
BP	GO:1901576	organic substance biosynthetic process	IEP	Predicted GO
BP	GO:1901987	regulation of cell cycle phase transition	IEP	Predicted GO
BP	GO:1901990	regulation of mitotic cell cycle phase transition	IEP	Predicted GO
BP	GO:1902099	regulation of metaphase/anaphase transition of cell cycle	IEP	Predicted GO
BP	GO:1905818	regulation of chromosome separation	IEP	Predicted GO
BP	GO:2000104	negative regulation of DNA-dependent DNA replication	IEP	Predicted GO
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:2000113	negative regulation of cellular macromolecule biosynthetic process	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR003874	CDC45	26	191
IPR003874	CDC45	166	344
IPR003874	CDC45	391	530

External Links

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evm.model.tig00001302.6

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation