Description : (at5g24630 : 114.0) This gene is predicted to encode a protein that forms part of the topoisomerase VI complex. BIN4 is a nuclear-localized protein that can bind DNA. bin4 mutants are brassinolide-insensitive dwarves with severely reduced cell size in leaves, roots, and hypocotyls. Proper development of root hairs and trichomes is also disrupted in bin4 mutants and they have elevated levels of double strand breaks in their cotyledon cells.; brassinosteroid-insensitive4 (BIN4); FUNCTIONS IN: double-stranded DNA binding; INVOLVED IN: in 7 processes; LOCATED IN: DNA topoisomerase complex (ATP-hydrolyzing), nucleus; EXPRESSED IN: cotyledon vascular system, cotyledon, root tip, leaf trichome, leaf; Has 3628 Blast hits to 2405 proteins in 320 species: Archae - 6; Bacteria - 1196; Metazoa - 1107; Fungi - 390; Plants - 165; Viruses - 17; Other Eukaryotes - 747 (source: NCBI BLink). & (reliability: 228.0) & (original description: no original description)
Gene families : OG_42_0004048 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0004048_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
| Type | Description | Actions |
|---|---|---|
| Neighborhood | Cyanophora release: evm.model.tig00020563.160 | |
| Cluster | HCCA clusters: Cluster_54 |
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
|---|---|---|---|---|---|
| Cre02.g105050 | No alias | double-stranded DNA binding | 0.02 | Orthogroups_2024-Update | |
| Pp1s31_246V6 | No alias | K18P6.17; hypothetical protein [Arabidopsis thaliana] | 0.02 | Orthogroups_2024-Update | |
| Seita.1G089600.1 | No alias | accessory component *(MIDGET) of meiotic topoisomerase-VI complex | 0.01 | Orthogroups_2024-Update | |
| Sobic.004G039900.1 | No alias | accessory component *(MIDGET) of meiotic topoisomerase-VI complex | 0.02 | Orthogroups_2024-Update | |
| Solyc03g079950 | No alias | double-stranded DNA binding protein (AHRD V3.3 *-* AT5G24630.9) | 0.01 | Orthogroups_2024-Update | |
| Sopen03g027470 | No alias | hypothetical protein | 0.01 | Orthogroups_2024-Update |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
No GO annotation available for this sequence |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| MF | GO:0000166 | nucleotide binding | IEP | Predicted GO |
| BP | GO:0000226 | microtubule cytoskeleton organization | IEP | Predicted GO |
| MF | GO:0000339 | RNA cap binding | IEP | Predicted GO |
| MF | GO:0000340 | RNA 7-methylguanosine cap binding | IEP | Predicted GO |
| MF | GO:0003676 | nucleic acid binding | IEP | Predicted GO |
| MF | GO:0003677 | DNA binding | IEP | Predicted GO |
| MF | GO:0003689 | DNA clamp loader activity | IEP | Predicted GO |
| MF | GO:0003729 | mRNA binding | IEP | Predicted GO |
| MF | GO:0003896 | DNA primase activity | IEP | Predicted GO |
| MF | GO:0005227 | calcium activated cation channel activity | IEP | Predicted GO |
| MF | GO:0005261 | cation channel activity | IEP | Predicted GO |
| MF | GO:0005267 | potassium channel activity | IEP | Predicted GO |
| MF | GO:0005488 | binding | IEP | Predicted GO |
| MF | GO:0005524 | ATP binding | IEP | Predicted GO |
| CC | GO:0005575 | cellular_component | IEP | Predicted GO |
| CC | GO:0005663 | DNA replication factor C complex | IEP | Predicted GO |
| CC | GO:0005694 | chromosome | IEP | Predicted GO |
| CC | GO:0005815 | microtubule organizing center | IEP | Predicted GO |
| BP | GO:0006139 | nucleobase-containing compound metabolic process | IEP | Predicted GO |
| BP | GO:0006259 | DNA metabolic process | IEP | Predicted GO |
| BP | GO:0006260 | DNA replication | IEP | Predicted GO |
| BP | GO:0006269 | DNA replication, synthesis of RNA primer | IEP | Predicted GO |
| BP | GO:0006270 | DNA replication initiation | IEP | Predicted GO |
| BP | GO:0006725 | cellular aromatic compound metabolic process | IEP | Predicted GO |
| BP | GO:0006813 | potassium ion transport | IEP | Predicted GO |
| BP | GO:0006996 | organelle organization | IEP | Predicted GO |
| BP | GO:0007010 | cytoskeleton organization | IEP | Predicted GO |
| BP | GO:0007062 | sister chromatid cohesion | IEP | Predicted GO |
| BP | GO:0007064 | mitotic sister chromatid cohesion | IEP | Predicted GO |
| MF | GO:0008094 | DNA-dependent ATPase activity | IEP | Predicted GO |
| MF | GO:0008144 | drug binding | IEP | Predicted GO |
| BP | GO:0009059 | macromolecule biosynthetic process | IEP | Predicted GO |
| BP | GO:0009987 | cellular process | IEP | Predicted GO |
| MF | GO:0015079 | potassium ion transmembrane transporter activity | IEP | Predicted GO |
| MF | GO:0015269 | calcium-activated potassium channel activity | IEP | Predicted GO |
| BP | GO:0016043 | cellular component organization | IEP | Predicted GO |
| MF | GO:0016286 | small conductance calcium-activated potassium channel activity | IEP | Predicted GO |
| MF | GO:0017076 | purine nucleotide binding | IEP | Predicted GO |
| BP | GO:0022402 | cell cycle process | IEP | Predicted GO |
| MF | GO:0022836 | gated channel activity | IEP | Predicted GO |
| MF | GO:0022839 | ion gated channel activity | IEP | Predicted GO |
| MF | GO:0030554 | adenyl nucleotide binding | IEP | Predicted GO |
| CC | GO:0031390 | Ctf18 RFC-like complex | IEP | Predicted GO |
| MF | GO:0031625 | ubiquitin protein ligase binding | IEP | Predicted GO |
| MF | GO:0032553 | ribonucleotide binding | IEP | Predicted GO |
| MF | GO:0032555 | purine ribonucleotide binding | IEP | Predicted GO |
| MF | GO:0032559 | adenyl ribonucleotide binding | IEP | Predicted GO |
| MF | GO:0033170 | protein-DNA loading ATPase activity | IEP | Predicted GO |
| BP | GO:0034453 | microtubule anchoring | IEP | Predicted GO |
| BP | GO:0034641 | cellular nitrogen compound metabolic process | IEP | Predicted GO |
| MF | GO:0035639 | purine ribonucleoside triphosphate binding | IEP | Predicted GO |
| MF | GO:0036094 | small molecule binding | IEP | Predicted GO |
| MF | GO:0043167 | ion binding | IEP | Predicted GO |
| MF | GO:0043168 | anion binding | IEP | Predicted GO |
| BP | GO:0043170 | macromolecule metabolic process | IEP | Predicted GO |
| CC | GO:0043226 | organelle | IEP | Predicted GO |
| CC | GO:0043228 | non-membrane-bounded organelle | IEP | Predicted GO |
| CC | GO:0043229 | intracellular organelle | IEP | Predicted GO |
| CC | GO:0043232 | intracellular non-membrane-bounded organelle | IEP | Predicted GO |
| BP | GO:0044260 | cellular macromolecule metabolic process | IEP | Predicted GO |
| MF | GO:0044389 | ubiquitin-like protein ligase binding | IEP | Predicted GO |
| CC | GO:0044422 | organelle part | IEP | Predicted GO |
| CC | GO:0044424 | intracellular part | IEP | Predicted GO |
| CC | GO:0044427 | chromosomal part | IEP | Predicted GO |
| CC | GO:0044446 | intracellular organelle part | IEP | Predicted GO |
| CC | GO:0044464 | cell part | IEP | Predicted GO |
| BP | GO:0046483 | heterocycle metabolic process | IEP | Predicted GO |
| BP | GO:0051259 | protein complex oligomerization | IEP | Predicted GO |
| BP | GO:0051260 | protein homooligomerization | IEP | Predicted GO |
| BP | GO:0051276 | chromosome organization | IEP | Predicted GO |
| BP | GO:0071840 | cellular component organization or biogenesis | IEP | Predicted GO |
| BP | GO:0090304 | nucleic acid metabolic process | IEP | Predicted GO |
| MF | GO:0097159 | organic cyclic compound binding | IEP | Predicted GO |
| MF | GO:0097367 | carbohydrate derivative binding | IEP | Predicted GO |
| MF | GO:1901265 | nucleoside phosphate binding | IEP | Predicted GO |
| BP | GO:1901360 | organic cyclic compound metabolic process | IEP | Predicted GO |
| MF | GO:1901363 | heterocyclic compound binding | IEP | Predicted GO |
| BP | GO:1903047 | mitotic cell cycle process | IEP | Predicted GO |
No InterPro domains available for this sequence
| No external refs found! |