evm.model.tig00021127.121

Description : (at5g42270 : 463.0) VAR1 contains a conserved motif for ATPase and a metalloprotease characteristic to FtsH proteins, and is targeted into chloroplasts. A VAR1-fusion protein synthesized in vitro exhibited ATPase activity and partial metalloprotease activity. This protein is located to the thylakoid membrane and forms a complex with VAR2. FtsH1 (VAR1) and FtsH5 are interchangeable in thylakoid membranes.; VARIEGATED 1 (VAR1); FUNCTIONS IN: metallopeptidase activity, ATP-dependent peptidase activity, ATPase activity; INVOLVED IN: photoinhibition, PSII associated light-harvesting complex II catabolic process, protein catabolic process; LOCATED IN: thylakoid, chloroplast thylakoid membrane, chloroplast, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M41, FtsH (InterPro:IPR005936), ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-type, conserved site (InterPro:IPR003960), Peptidase M41 (InterPro:IPR000642); BEST Arabidopsis thaliana protein match is: FTSH protease 1 (TAIR:AT1G50250.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink). & (q9bae0|ftsh_medsa : 462.0) Cell division protease ftsH homolog, chloroplast precursor (EC 3.4.24.-) - Medicago sativa (Alfalfa) & (reliability: 926.0) & (original description: no original description)

Gene families : OG_42_0001288 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001288_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Cyanophora release: evm.model.tig00021127.121
Cluster	HCCA clusters: Cluster_15

Target	Alias	Description	ECC score	Gene Family Method
149856	No alias	FtsH extracellular protease family	0.02	Orthogroups_2024-Update
At1g06430	No alias	ATP-dependent zinc metalloprotease FTSH 8, chloroplastic...	0.01	Orthogroups_2024-Update
At5g15250	No alias	ATP-dependent zinc metalloprotease FTSH 6, chloroplastic...	0.01	Orthogroups_2024-Update
At5g42270	No alias	VAR1 [Source:UniProtKB/TrEMBL;Acc:A0A178U8J6]	0.02	Orthogroups_2024-Update
Brara.H02960.1	No alias	protease *(FtsH2/8) & EXECUTER-cleavage protease...	0.03	Orthogroups_2024-Update
Brara.J00441.1	No alias	protease *(FtsH2/8) & EXECUTER-cleavage protease...	0.05	Orthogroups_2024-Update
Glyma.09G052600	No alias	FTSH protease 8	0.02	Orthogroups_2024-Update
Mp3g08790.1	No alias	component FtsH1\|2\|5\|6\|8 of FtsH plastidial protease complexes	0.03	Orthogroups_2024-Update
Mp4g19200.1	No alias	component FtsH1\|2\|5\|6\|8 of FtsH plastidial protease complexes	0.03	Orthogroups_2024-Update
PSME_00003738-RA	No alias	(at1g06430 : 965.0) encodes a FtsH protease that is...	0.01	Orthogroups_2024-Update
PSME_00014507-RA	No alias	(at2g30950 : 828.0) Metalloprotease that functions in...	0.01	Orthogroups_2024-Update
Potri.014G139500	No alias	FtsH extracellular protease family	0.02	Orthogroups_2024-Update
Pp1s118_166V6	No alias	aaa-metalloprotease chloroplast precursor	0.01	Orthogroups_2024-Update
Pp1s156_30V6	No alias	cell division protein	0.05	Orthogroups_2024-Update
Pp1s9_115V6	No alias	cell division protein	0.04	Orthogroups_2024-Update
Seita.4G099200.1	No alias	EXECUTER-cleavage protease *(FtsH2) & protease...	0.02	Orthogroups_2024-Update
Sobic.010G092900.1	No alias	EXECUTER-cleavage protease *(FtsH2) & protease...	0.01	Orthogroups_2024-Update
Sopen07g026900	No alias	Peptidase family M41	0.01	Orthogroups_2024-Update
evm.model.contig_503.12	No alias	(at1g50250 : 579.0) encodes an FTSH protease that is...	0.01	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004175	endopeptidase activity	None	Extended
MF	GO:0004222	metalloendopeptidase activity	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	InterProScan predictions
BP	GO:0006508	proteolysis	IEA	InterProScan predictions
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008233	peptidase activity	None	Extended
MF	GO:0008237	metallopeptidase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0004788	thiamine diphosphokinase activity	IEP	Predicted GO
MF	GO:0005215	transporter activity	IEP	Predicted GO
MF	GO:0005244	voltage-gated ion channel activity	IEP	Predicted GO
MF	GO:0005247	voltage-gated chloride channel activity	IEP	Predicted GO
MF	GO:0005253	anion channel activity	IEP	Predicted GO
MF	GO:0005254	chloride channel activity	IEP	Predicted GO
MF	GO:0005543	phospholipid binding	IEP	Predicted GO
CC	GO:0005575	cellular_component	IEP	Predicted GO
BP	GO:0006810	transport	IEP	Predicted GO
BP	GO:0006813	potassium ion transport	IEP	Predicted GO
BP	GO:0006821	chloride transport	IEP	Predicted GO
MF	GO:0008308	voltage-gated anion channel activity	IEP	Predicted GO
BP	GO:0008610	lipid biosynthetic process	IEP	Predicted GO
BP	GO:0009119	ribonucleoside metabolic process	IEP	Predicted GO
BP	GO:0009229	thiamine diphosphate biosynthetic process	IEP	Predicted GO
MF	GO:0015108	chloride transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015298	solute:cation antiporter activity	IEP	Predicted GO
MF	GO:0015299	solute:proton antiporter activity	IEP	Predicted GO
MF	GO:0015399	primary active transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	IEP	Predicted GO
BP	GO:0015969	guanosine tetraphosphate metabolic process	IEP	Predicted GO
CC	GO:0016020	membrane	IEP	Predicted GO
CC	GO:0016021	integral component of membrane	IEP	Predicted GO
MF	GO:0016462	pyrophosphatase activity	IEP	Predicted GO
MF	GO:0016491	oxidoreductase activity	IEP	Predicted GO
MF	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	IEP	Predicted GO
MF	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEP	Predicted GO
MF	GO:0016778	diphosphotransferase activity	IEP	Predicted GO
MF	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	IEP	Predicted GO
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	IEP	Predicted GO
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEP	Predicted GO
MF	GO:0016887	ATPase activity	IEP	Predicted GO
BP	GO:0017004	cytochrome complex assembly	IEP	Predicted GO
MF	GO:0017111	nucleoside-triphosphatase activity	IEP	Predicted GO
MF	GO:0022804	active transmembrane transporter activity	IEP	Predicted GO
MF	GO:0022832	voltage-gated channel activity	IEP	Predicted GO
MF	GO:0022857	transmembrane transporter activity	IEP	Predicted GO
CC	GO:0031224	intrinsic component of membrane	IEP	Predicted GO
BP	GO:0033865	nucleoside bisphosphate metabolic process	IEP	Predicted GO
BP	GO:0033875	ribonucleoside bisphosphate metabolic process	IEP	Predicted GO
BP	GO:0034032	purine nucleoside bisphosphate metabolic process	IEP	Predicted GO
BP	GO:0034035	purine ribonucleoside bisphosphate metabolic process	IEP	Predicted GO
BP	GO:0042278	purine nucleoside metabolic process	IEP	Predicted GO
BP	GO:0042357	thiamine diphosphate metabolic process	IEP	Predicted GO
MF	GO:0042623	ATPase activity, coupled	IEP	Predicted GO
MF	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	IEP	Predicted GO
MF	GO:0043492	ATPase activity, coupled to movement of substances	IEP	Predicted GO
CC	GO:0044425	membrane part	IEP	Predicted GO
BP	GO:0046128	purine ribonucleoside metabolic process	IEP	Predicted GO
BP	GO:0051179	localization	IEP	Predicted GO
MF	GO:0051213	dioxygenase activity	IEP	Predicted GO
BP	GO:0051234	establishment of localization	IEP	Predicted GO
BP	GO:0055085	transmembrane transport	IEP	Predicted GO
BP	GO:0055114	oxidation-reduction process	IEP	Predicted GO
MF	GO:0071949	FAD binding	IEP	Predicted GO
BP	GO:0072527	pyrimidine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072528	pyrimidine-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:1901068	guanosine-containing compound metabolic process	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR000642	Peptidase_M41	1004	1042
IPR003959	ATPase_AAA_core	790	923

External Links

No external refs found!

evm.model.tig00021127.121

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation