Kfl00046_0270 (kfl00046_0270_v1.1)

Aliases : kfl00046_0270_v1.1

Description : (at5g57160 : 786.0) Encodes the Arabidopsis orthologue of the yeast and mammalian DNA ligase IV. Involved in the repair of DNA damage but, unlike in yeast, not required for T-DNA integration. Interacts with the Arabidopsis homologue of XRCC4.; ATLIG4; FUNCTIONS IN: protein binding, DNA ligase (ATP) activity; INVOLVED IN: double-strand break repair, response to X-ray, response to DNA damage stimulus; LOCATED IN: intracellular; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold (InterPro:IPR012340), DNA ligase, N-terminal (InterPro:IPR012308), ATP dependent DNA ligase, central (InterPro:IPR012310), ATP dependent DNA ligase, C-terminal (InterPro:IPR012309), ATP-dependent DNA ligase, conserved site (InterPro:IPR016059), ATP-dependent DNA ligase (InterPro:IPR000977), BRCT (InterPro:IPR001357); BEST Arabidopsis thaliana protein match is: DNA ligase 1 (TAIR:AT1G08130.1); Has 7656 Blast hits to 6618 proteins in 1076 species: Archae - 317; Bacteria - 1869; Metazoa - 2250; Fungi - 907; Plants - 304; Viruses - 214; Other Eukaryotes - 1795 (source: NCBI BLink). & (q7x7e9|dnl4_orysa : 592.0) Putative DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) - Oryza sativa (Rice) & (reliability: 1572.0) & (original description: no original description)

Gene families : OG_42_0003659 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0003659_tree

Sequence : coding (download), protein (download)

Download

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Klebsormidium release: Kfl00046_0270
Cluster	HCCA clusters: Cluster_80

Target	Alias	Description	ECC score	Gene Family Method
Glyma.15G166700	No alias	DNA ligase IV	0.02	Orthogroups_2024-Update
Solyc07g017990	No alias	DNA ligase (AHRD V3.3 *** K4CCL3_SOLLC)	0.02	Orthogroups_2024-Update
Sopen07g006920	No alias	DNA ligase N terminus	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	InterProScan predictions
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003909	DNA ligase activity	None	Extended
MF	GO:0003910	DNA ligase (ATP) activity	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	InterProScan predictions
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006281	DNA repair	IEA	InterProScan predictions
BP	GO:0006310	DNA recombination	IEA	InterProScan predictions
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016874	ligase activity	None	Extended
MF	GO:0016886	ligase activity, forming phosphoric ester bonds	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
MF	GO:0003873	6-phosphofructo-2-kinase activity	IEP	Predicted GO
BP	GO:0006000	fructose metabolic process	IEP	Predicted GO
BP	GO:0006471	protein ADP-ribosylation	IEP	Predicted GO
BP	GO:0006479	protein methylation	IEP	Predicted GO
MF	GO:0008170	N-methyltransferase activity	IEP	Predicted GO
BP	GO:0008213	protein alkylation	IEP	Predicted GO
MF	GO:0008270	zinc ion binding	IEP	Predicted GO
MF	GO:0008276	protein methyltransferase activity	IEP	Predicted GO
MF	GO:0008443	phosphofructokinase activity	IEP	Predicted GO
MF	GO:0016278	lysine N-methyltransferase activity	IEP	Predicted GO
MF	GO:0016279	protein-lysine N-methyltransferase activity	IEP	Predicted GO
BP	GO:0016571	histone methylation	IEP	Predicted GO
MF	GO:0016851	magnesium chelatase activity	IEP	Predicted GO
BP	GO:0018022	peptidyl-lysine methylation	IEP	Predicted GO
MF	GO:0018024	histone-lysine N-methyltransferase activity	IEP	Predicted GO
MF	GO:0019200	carbohydrate kinase activity	IEP	Predicted GO
BP	GO:0034968	histone lysine methylation	IEP	Predicted GO
MF	GO:0042054	histone methyltransferase activity	IEP	Predicted GO
MF	GO:0046914	transition metal ion binding	IEP	Predicted GO
MF	GO:0051002	ligase activity, forming nitrogen-metal bonds	IEP	Predicted GO
MF	GO:0051003	ligase activity, forming nitrogen-metal bonds, forming coordination complexes	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR001357	BRCT_dom	677	761
IPR012309	DNA_ligase_ATP-dep_C	493	611
IPR012308	DNA_ligase_ATP-dep_N	17	194
IPR012310	DNA_ligase_ATP-dep_cent	234	468

External Links

No external refs found!

Kfl00046_0270 (kfl00046_0270_v1.1)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation