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  5. Kfl00057_0130

Kfl00057_0130 (kfl00057_0130_v1.1)


Aliases : kfl00057_0130_v1.1

Description : (at5g58220 : 173.0) Encodes a transthyretin-like S-allantoin synthase protein that catalyzes two steps in the allantoin biosynthesis pathway by acting as a hydroxyisourate hydrolase and a 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) decarboxylase. Two alternatively spliced versions of the transcript give rise to a longer peroxisomally-targeted protein (AT5G58220.1 (called TTL1-)) and a slightly shorter cytoplasmic protein (AT5G58220.3 (called TTL2-)). Both have roughly equivalent enzymatic activity in vitro, but, allantoin biosynthesis is believed to occur in the peroxisome suggesting that the cytosolic form may participate in a different process.; transthyretin-like protein (TTL); FUNCTIONS IN: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity, hydroxyisourate hydrolase activity; INVOLVED IN: regulation of cell growth by extracellular stimulus, brassinosteroid mediated signaling pathway, protein homotetramerization; LOCATED IN: cytosol, extrinsic to internal side of plasma membrane, peroxisome; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Bifunctional hydroxyisourate hydrolase/2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (InterPro:IPR017129), Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (InterPro:IPR018020), Hydroxyisourate hydrolase (InterPro:IPR014306), Transthyretin/hydroxyisourate hydrolase (InterPro:IPR000895); Has 3236 Blast hits to 3236 proteins in 817 species: Archae - 6; Bacteria - 1906; Metazoa - 529; Fungi - 103; Plants - 58; Viruses - 0; Other Eukaryotes - 634 (source: NCBI BLink). & (reliability: 346.0) & (original description: no original description)


Gene families : OG_42_0005666 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0005666_tree

Sequence : coding (download), protein (download)


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Type Description Actions
Neighborhood Klebsormidium release: Kfl00057_0130
Cluster HCCA clusters: Cluster_133

Target Alias Description ECC score Gene Family Method Actions
402204 No alias transthyretin-like protein 0.02 Orthogroups_2024-Update
Cre17.g735950 No alias transthyretin-like protein 0.02 Orthogroups_2024-Update

Type GO Term Name Evidence Source

No GO annotation available for this sequence
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Type GO Term Name Evidence Source
MF GO:0004175 endopeptidase activity IEP Predicted GO
MF GO:0004298 threonine-type endopeptidase activity IEP Predicted GO
CC GO:0005575 cellular_component IEP Predicted GO
CC GO:0005739 mitochondrion IEP Predicted GO
CC GO:0005744 TIM23 mitochondrial import inner membrane translocase complex IEP Predicted GO
CC GO:0005839 proteasome core complex IEP Predicted GO
BP GO:0006508 proteolysis IEP Predicted GO
BP GO:0006511 ubiquitin-dependent protein catabolic process IEP Predicted GO
BP GO:0006839 mitochondrial transport IEP Predicted GO
MF GO:0008233 peptidase activity IEP Predicted GO
BP GO:0009056 catabolic process IEP Predicted GO
BP GO:0009057 macromolecule catabolic process IEP Predicted GO
MF GO:0016787 hydrolase activity IEP Predicted GO
BP GO:0017038 protein import IEP Predicted GO
CC GO:0019773 proteasome core complex, alpha-subunit complex IEP Predicted GO
CC GO:0019898 extrinsic component of membrane IEP Predicted GO
BP GO:0019941 modification-dependent protein catabolic process IEP Predicted GO
BP GO:0030150 protein import into mitochondrial matrix IEP Predicted GO
CC GO:0032991 protein-containing complex IEP Predicted GO
BP GO:0033365 protein localization to organelle IEP Predicted GO
BP GO:0034613 cellular protein localization IEP Predicted GO
BP GO:0043632 modification-dependent macromolecule catabolic process IEP Predicted GO
BP GO:0044248 cellular catabolic process IEP Predicted GO
BP GO:0044265 cellular macromolecule catabolic process IEP Predicted GO
CC GO:0044424 intracellular part IEP Predicted GO
CC GO:0044455 mitochondrial membrane part IEP Predicted GO
CC GO:0044464 cell part IEP Predicted GO
BP GO:0044743 protein transmembrane import into intracellular organelle IEP Predicted GO
MF GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer IEP Predicted GO
BP GO:0051603 proteolysis involved in cellular protein catabolic process IEP Predicted GO
BP GO:0065002 intracellular protein transmembrane transport IEP Predicted GO
MF GO:0070003 threonine-type peptidase activity IEP Predicted GO
MF GO:0070011 peptidase activity, acting on L-amino acid peptides IEP Predicted GO
BP GO:0070585 protein localization to mitochondrion IEP Predicted GO
BP GO:0070727 cellular macromolecule localization IEP Predicted GO
BP GO:0071806 protein transmembrane transport IEP Predicted GO
BP GO:0072594 establishment of protein localization to organelle IEP Predicted GO
BP GO:0072655 establishment of protein localization to mitochondrion IEP Predicted GO
CC GO:0098796 membrane protein complex IEP Predicted GO
CC GO:0098798 mitochondrial protein complex IEP Predicted GO
CC GO:0098800 inner mitochondrial membrane protein complex IEP Predicted GO
BP GO:1901575 organic substance catabolic process IEP Predicted GO
BP GO:1990542 mitochondrial transmembrane transport IEP Predicted GO
InterPro domains Description Start Stop
IPR018020 OHCU_decarboxylase 14 172
IPR023416 Transthyretin/HIU_hydrolase_d 295 417
No external refs found!