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  5. Kfl00184_0180

Kfl00184_0180 (kfl00184_0180_v1.1,...)


Aliases : kfl00184_0180_v1.1, kfl00184_0180_v1.1

Description : (at3g13300 : 294.0) Encodes VCS (VARICOSE). Involved in mRNA decapping. VCS forms a mRNA decapping complex with DCP1 (At1g08370) and DCP2 (At5g13570). Unlike DCP2, VCS itself does not have mRNA decapping activity in vitro. DCP1, DCP2 and VCS colocalize in cytoplasmic loci, which are putative Arabidopsis mRNA processing bodies. Null mutants of DCP1, DCP2, and VCS accumulate capped mRNAs with a reduced degradation rate. These mutants also share a similar lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology. VCS is also required for leaf development.; VARICOSE (VCS); FUNCTIONS IN: protein homodimerization activity, nucleotide binding; INVOLVED IN: mRNA catabolic process, deadenylation-independent decapping of nuclear-transcribed mRNA, leaf morphogenesis; LOCATED IN: cytosol, nucleus, cytoplasmic mRNA processing body; EXPRESSED IN: whole plant, guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat 2 (InterPro:IPR019782), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: varicose-related (TAIR:AT3G13290.1); Has 885 Blast hits to 799 proteins in 264 species: Archae - 2; Bacteria - 218; Metazoa - 230; Fungi - 185; Plants - 114; Viruses - 4; Other Eukaryotes - 132 (source: NCBI BLink). & (reliability: 588.0) & (original description: no original description)


Gene families : OG_42_0001770 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001770_tree

Sequence : coding (download), protein (download)


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Type Description Actions
Neighborhood Klebsormidium release: Kfl00184_0180
Cluster HCCA clusters: Cluster_128

Target Alias Description ECC score Gene Family Method Actions
Bradi3g56517 No alias varicose-related 0.02 Orthogroups_2024-Update
Glyma.08G337400 No alias Transducin/WD40 repeat-like superfamily protein 0.02 Orthogroups_2024-Update
Glyma.09G016800 No alias Transducin/WD40 repeat-like superfamily protein 0.02 Orthogroups_2024-Update
Glyma.15G122400 No alias varicose-related 0.03 Orthogroups_2024-Update
Glyma.18G072400 No alias Transducin/WD40 repeat-like superfamily protein 0.02 Orthogroups_2024-Update
Seita.4G131500.1 No alias scaffold component *(VCS) of mRNA decapping complex 0.02 Orthogroups_2024-Update

Type GO Term Name Evidence Source

No GO annotation available for this sequence
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Type GO Term Name Evidence Source
MF GO:0005543 phospholipid binding IEP Predicted GO
BP GO:0006357 regulation of transcription by RNA polymerase II IEP Predicted GO
BP GO:0006606 protein import into nucleus IEP Predicted GO
BP GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IEP Predicted GO
BP GO:0006913 nucleocytoplasmic transport IEP Predicted GO
BP GO:0007030 Golgi organization IEP Predicted GO
BP GO:0007186 G protein-coupled receptor signaling pathway IEP Predicted GO
CC GO:0016592 mediator complex IEP Predicted GO
BP GO:0017038 protein import IEP Predicted GO
CC GO:0030286 dynein complex IEP Predicted GO
MF GO:0031683 G-protein beta/gamma-subunit complex binding IEP Predicted GO
BP GO:0033365 protein localization to organelle IEP Predicted GO
BP GO:0034504 protein localization to nucleus IEP Predicted GO
MF GO:0035091 phosphatidylinositol binding IEP Predicted GO
MF GO:0044877 protein-containing complex binding IEP Predicted GO
BP GO:0051169 nuclear transport IEP Predicted GO
BP GO:0051170 import into nucleus IEP Predicted GO
BP GO:0072594 establishment of protein localization to organelle IEP Predicted GO
InterPro domains Description Start Stop
IPR032401 EDC4_WD40 341 474
No external refs found!