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- Kfl00397_0070
Kfl00397_0070 (kfl00397_0070_v1.1,...)
Aliases : kfl00397_0070_v1.1, kfl00397_0070_v1.1
Description : (q2qmg2|mcca_orysa : 420.0) Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) - Oryza sativa (Rice) & (at1g03090 : 404.0) MCCA is the biotinylated subunit of the dimer MCCase, which is involved in leucine degradation. Both subunits are nuclear coded and the active enzyme is located in the mitochondrion.; MCCA; FUNCTIONS IN: cobalt ion binding, methylcrotonoyl-CoA carboxylase activity; INVOLVED IN: leucine catabolic process; LOCATED IN: mitochondrion, cytosolic ribosome; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089), Carbamoyl phosphate synthase, large subunit, N-terminal (InterPro:IPR005481), Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), PreATP-grasp-like fold (InterPro:IPR016185), Biotin-binding site (InterPro:IPR001882), Biotin carboxylation domain (InterPro:IPR011764), Biotin carboxylase, C-terminal (InterPro:IPR005482), ATP-grasp fold (InterPro:IPR011761), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), Rudiment single hybrid motif (InterPro:IPR011054), Pre-ATP-grasp fold (InterPro:IPR013817); BEST Arabidopsis thaliana protein match is: acetyl Co-enzyme a carboxylase biotin carboxylase subunit (TAIR:AT5G35360.1); Has 41492 Blast hits to 34824 proteins in 3674 species: Archae - 718; Bacteria - 26555; Metazoa - 1797; Fungi - 1117; Plants - 802; Viruses - 0; Other Eukaryotes - 10503 (source: NCBI BLink). & (reliability: 808.0) & (original description: no original description)
Expression Profile
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Co-expression Networks
| Type | Description | Actions |
| Neighborhood | Klebsormidium release: Kfl00397_0070 | |
| Cluster | HCCA clusters: Cluster_1 | |
Expression Context Conservation (ECC)
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
| HORVU5Hr1G012900.9 | No alias | EC_6.4 ligase forming carbon-carbon bond & subunit alpha... | 0.02 | Orthogroups_2024-Update | |
| Seita.3G382100.1 | No alias | EC_6.4 ligase forming carbon-carbon bond & subunit alpha... | 0.02 | Orthogroups_2024-Update | |
Functional Annotation
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0000166 | nucleotide binding | None | Extended |
| MF | GO:0003674 | molecular_function | None | Extended |
| MF | GO:0005488 | binding | None | Extended |
| MF | GO:0005524 | ATP binding | IEA | InterProScan predictions |
| MF | GO:0008144 | drug binding | None | Extended |
| MF | GO:0017076 | purine nucleotide binding | None | Extended |
| MF | GO:0030554 | adenyl nucleotide binding | None | Extended |
| MF | GO:0032553 | ribonucleotide binding | None | Extended |
| MF | GO:0032555 | purine ribonucleotide binding | None | Extended |
| MF | GO:0032559 | adenyl ribonucleotide binding | None | Extended |
| MF | GO:0035639 | purine ribonucleoside triphosphate binding | None | Extended |
| MF | GO:0036094 | small molecule binding | None | Extended |
| MF | GO:0043167 | ion binding | None | Extended |
| MF | GO:0043168 | anion binding | None | Extended |
| MF | GO:0097159 | organic cyclic compound binding | None | Extended |
| MF | GO:0097367 | carbohydrate derivative binding | None | Extended |
| MF | GO:1901265 | nucleoside phosphate binding | None | Extended |
| MF | GO:1901363 | heterocyclic compound binding | None | Extended |
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0003684 | damaged DNA binding | IEP | Predicted GO |
| MF | GO:0003779 | actin binding | IEP | Predicted GO |
| MF | GO:0003918 | DNA topoisomerase type II (ATP-hydrolyzing) activity | IEP | Predicted GO |
| MF | GO:0004435 | phosphatidylinositol phospholipase C activity | IEP | Predicted GO |
| MF | GO:0004525 | ribonuclease III activity | IEP | Predicted GO |
| MF | GO:0004620 | phospholipase activity | IEP | Predicted GO |
| MF | GO:0004629 | phospholipase C activity | IEP | Predicted GO |
| MF | GO:0005506 | iron ion binding | IEP | Predicted GO |
| MF | GO:0008092 | cytoskeletal protein binding | IEP | Predicted GO |
| MF | GO:0016298 | lipase activity | IEP | Predicted GO |
| MF | GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEP | Predicted GO |
| MF | GO:0020037 | heme binding | IEP | Predicted GO |
| CC | GO:0030880 | RNA polymerase complex | IEP | Predicted GO |
| MF | GO:0031625 | ubiquitin protein ligase binding | IEP | Predicted GO |
| MF | GO:0032296 | double-stranded RNA-specific ribonuclease activity | IEP | Predicted GO |
| MF | GO:0044389 | ubiquitin-like protein ligase binding | IEP | Predicted GO |
| MF | GO:0046906 | tetrapyrrole binding | IEP | Predicted GO |
| MF | GO:0061505 | DNA topoisomerase II activity | IEP | Predicted GO |
| CC | GO:0061695 | transferase complex, transferring phosphorus-containing groups | IEP | Predicted GO |
| CC | GO:1902494 | catalytic complex | IEP | Predicted GO |
| InterPro domains | Description | Start | Stop |
| IPR005479 | CbamoylP_synth_lsu-like_ATP-bd | 289 | 496 |
| IPR005481 | BC-like_N | 176 | 284 |
| IPR005482 | Biotin_COase_C | 511 | 626 |
| IPR000089 | Biotin_lipoyl | 782 | 846 |
