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  5. MA_10432100g0020

MA_10432100g0020


Description : (at1g57820 : 536.0) Encodes a 645-amino acid methylcytosine-binding protein with a PHD domain, two RING finger domains, and an SRA domain that is involved in centromere heterochromatinization. This protein functions as an E3 ubiquitin ligase in vitro. The protein has been shown to bind to methylated cytosines of CG, CNG and CNN motifs via its SRA domain but has a preference for the former. It plays a role in the establishment/maintenance of chromatin structure during cell division and is localized in the nucleus. Plants over-expressing VIM1/ORTH2 show an inhibition in root growth and a delay in flowering. Both over-expression of GFP:ORTH2 and loss of ORTH2/VIM1 lead to decreased levels of DNA methylation. GFP:ORTH2 over-expressers also have increased levels of FWA transcripts.; VARIANT IN METHYLATION 1 (VIM1); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, PHD-type (InterPro:IPR001965), SRA-YDG (InterPro:IPR003105), Zinc finger, C3HC4 RING-type (InterPro:IPR018957), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: zinc finger (C3HC4-type RING finger) family protein (TAIR:AT1G57800.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink). & (reliability: 1072.0) & (original description: no original description)


Gene families : OG_42_0002900 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0002900_tree

Sequence : coding (download), protein (download)


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Type Description Actions
Neighborhood Picea release: MA_10432100g0020
Cluster HCCA clusters: Cluster_112


Type GO Term Name Evidence Source

No GO annotation available for this sequence
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Type GO Term Name Evidence Source
MF GO:0003676 nucleic acid binding IEP Predicted GO
MF GO:0003723 RNA binding IEP Predicted GO
MF GO:0004806 triglyceride lipase activity IEP Predicted GO
MF GO:0004842 ubiquitin-protein transferase activity IEP Predicted GO
BP GO:0006575 cellular modified amino acid metabolic process IEP Predicted GO
BP GO:0006658 phosphatidylserine metabolic process IEP Predicted GO
BP GO:0006659 phosphatidylserine biosynthetic process IEP Predicted GO
BP GO:0008654 phospholipid biosynthetic process IEP Predicted GO
MF GO:0016298 lipase activity IEP Predicted GO
MF GO:0019787 ubiquitin-like protein transferase activity IEP Predicted GO
BP GO:0042398 cellular modified amino acid biosynthetic process IEP Predicted GO
MF GO:0043565 sequence-specific DNA binding IEP Predicted GO
BP GO:0046474 glycerophospholipid biosynthetic process IEP Predicted GO
BP GO:0070647 protein modification by small protein conjugation or removal IEP Predicted GO
InterPro domains Description Start Stop
IPR027370 Znf-RING_LisH 510 539
IPR019787 Znf_PHD-finger 11 57
IPR003105 SRA_YDG 288 406
No external refs found!