MA_10437242g0030

Description : (q43082|hem3_pea : 487.0) Porphobilinogen deaminase, chloroplast precursor (EC 2.5.1.61) (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) - Pisum sativum (Garden pea) & (at5g08280 : 484.0) Encodes a protein with porphobilinogen deaminase activity. This protein is targeted to the chloroplast.; hydroxymethylbilane synthase (HEMC); FUNCTIONS IN: hydroxymethylbilane synthase activity; INVOLVED IN: chlorophyll biosynthetic process, defense response to bacterium, porphyrin biosynthetic process; LOCATED IN: apoplast, chloroplast, chloroplast stroma, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Porphobilinogen deaminase, dipyrromethane cofactor binding site (InterPro:IPR022419), Tetrapyrrole biosynthesis, hydroxymethylbilane synthase (InterPro:IPR000860), Porphobilinogen deaminase, N-terminal (InterPro:IPR022417), Porphobilinogen deaminase, C-terminal domain (InterPro:IPR022418); Has 7343 Blast hits to 7329 proteins in 2247 species: Archae - 198; Bacteria - 4150; Metazoa - 157; Fungi - 178; Plants - 78; Viruses - 0; Other Eukaryotes - 2582 (source: NCBI BLink). & (reliability: 968.0) & (original description: no original description)

Gene families : OG_42_0004692 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0004692_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Picea release: MA_10437242g0030
Cluster	HCCA clusters: Cluster_80

Target	Alias	Description	ECC score	Gene Family Method
Cre16.g663900	No alias	hydroxymethylbilane synthase	0.01	Orthogroups_2024-Update
Kfl00058_0350	kfl00058_0350_v1.1	(q43082\|hem3_pea : 476.0) Porphobilinogen deaminase,...	0.02	Orthogroups_2024-Update
Mp2g07740.1	No alias	porphobilinogen deaminase	0.02	Orthogroups_2024-Update
Pp1s116_53V6	No alias	porphobilinogen deaminase	0.02	Orthogroups_2024-Update
evm.model.tig00000241.50	No alias	(q43082\|hem3_pea : 177.0) Porphobilinogen deaminase,...	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004418	hydroxymethylbilane synthase activity	IEA	InterProScan predictions
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	None	Extended
BP	GO:0018130	heterocycle biosynthetic process	None	Extended
BP	GO:0019438	aromatic compound biosynthetic process	None	Extended
BP	GO:0033013	tetrapyrrole metabolic process	None	Extended
BP	GO:0033014	tetrapyrrole biosynthetic process	IEA	InterProScan predictions
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044271	cellular nitrogen compound biosynthetic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901362	organic cyclic compound biosynthetic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000413	protein peptidyl-prolyl isomerization	IEP	Predicted GO
MF	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IEP	Predicted GO
MF	GO:0004325	ferrochelatase activity	IEP	Predicted GO
MF	GO:0004853	uroporphyrinogen decarboxylase activity	IEP	Predicted GO
BP	GO:0006778	porphyrin-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006779	porphyrin-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0006783	heme biosynthetic process	IEP	Predicted GO
MF	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	IEP	Predicted GO
CC	GO:0009507	chloroplast	IEP	Predicted GO
CC	GO:0009536	plastid	IEP	Predicted GO
BP	GO:0010207	photosystem II assembly	IEP	Predicted GO
BP	GO:0015994	chlorophyll metabolic process	IEP	Predicted GO
BP	GO:0015995	chlorophyll biosynthetic process	IEP	Predicted GO
MF	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016636	oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor	IEP	Predicted GO
MF	GO:0016851	magnesium chelatase activity	IEP	Predicted GO
MF	GO:0016859	cis-trans isomerase activity	IEP	Predicted GO
MF	GO:0016874	ligase activity	IEP	Predicted GO
BP	GO:0017038	protein import	IEP	Predicted GO
BP	GO:0018208	peptidyl-proline modification	IEP	Predicted GO
BP	GO:0042168	heme metabolic process	IEP	Predicted GO
BP	GO:0042440	pigment metabolic process	IEP	Predicted GO
BP	GO:0046148	pigment biosynthetic process	IEP	Predicted GO
MF	GO:0046406	magnesium protoporphyrin IX methyltransferase activity	IEP	Predicted GO
MF	GO:0046422	violaxanthin de-epoxidase activity	IEP	Predicted GO
MF	GO:0050660	flavin adenine dinucleotide binding	IEP	Predicted GO
MF	GO:0051002	ligase activity, forming nitrogen-metal bonds	IEP	Predicted GO
MF	GO:0051003	ligase activity, forming nitrogen-metal bonds, forming coordination complexes	IEP	Predicted GO
BP	GO:0051186	cofactor metabolic process	IEP	Predicted GO
BP	GO:0051188	cofactor biosynthetic process	IEP	Predicted GO
MF	GO:0051743	red chlorophyll catabolite reductase activity	IEP	Predicted GO
MF	GO:0071949	FAD binding	IEP	Predicted GO
MF	GO:2001070	starch binding	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR022417	Porphobilin_deaminase_N	65	275
IPR022418	Porphobilinogen_deaminase_C	289	361

External Links

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MA_10437242g0030

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation