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Description : (p31687|4cl2_soybn : 667.0) 4-coumarate--CoA ligase 2 (EC 6.2.1.12) (4CL 2) (4-coumaroyl-CoA synthase 2) (Clone 4CL16) - Glycine max (Soybean) & (at1g65060 : 649.0) encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. mRNA levels are not induced in response to wounding or to fungal infection by P. parasitica. mRNA is expressed in flowers, to a lesser degree in mature leaves and siliques and marginally in seedling roots and bolting stems of mature plants. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, ferulic acid, cinnamic acid and 5-OH-ferulic acid. At4CL3 was unable to use sinapic acid as substrate.; 4-coumarate:CoA ligase 3 (4CL3); CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: 4-coumarate:CoA ligase 2 (TAIR:AT3G21240.1); Has 78268 Blast hits to 71395 proteins in 3651 species: Archae - 1111; Bacteria - 51774; Metazoa - 3299; Fungi - 4373; Plants - 2538; Viruses - 1; Other Eukaryotes - 15172 (source: NCBI BLink). & (reliability: 1298.0) & (original description: no original description)
Gene families : OG_42_0000133 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000133_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
| Type | Description | Actions |
|---|---|---|
| Neighborhood | Picea release: MA_109119g0010 | |
| Cluster | HCCA clusters: Cluster_22 |
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
|---|---|---|---|---|---|
| 171251 | No alias | 4-coumarate:CoA ligase 2 | 0.04 | Orthogroups_2024-Update | |
| 177466 | No alias | OPC-8:0 CoA ligase1 | 0.03 | Orthogroups_2024-Update | |
| A4A49_10638 | No alias | 4-coumarate--coa ligase 2 | 0.05 | Orthogroups_2024-Update | |
| A4A49_40482 | No alias | 4-coumarate--coa ligase 1 | 0.04 | Orthogroups_2024-Update | |
| A4A49_41306 | No alias | 4-coumarate--coa ligase 2 | 0.04 | Orthogroups_2024-Update | |
| At1g51680 | No alias | 4-coumarate-CoA ligase 1 [Source:UniProtKB/TrEMBL;Acc:A0A1P8SNN0] | 0.05 | Orthogroups_2024-Update | |
| At1g65060 | No alias | 4-coumarate--CoA ligase 3... | 0.05 | Orthogroups_2024-Update | |
| Bradi3g05750 | No alias | 4-coumarate:CoA ligase 2 | 0.03 | Orthogroups_2024-Update | |
| Bradi3g52350 | No alias | 4-coumarate:CoA ligase 3 | 0.05 | Orthogroups_2024-Update | |
| Bradi5g04760 | No alias | acyl-CoA synthetase 5 | 0.03 | Orthogroups_2024-Update | |
| Brara.G02592.1 | No alias | p-coumarate | 0.03 | Orthogroups_2024-Update | |
| Glyma.10G197900 | No alias | OPC-8:0 CoA ligase1 | 0.03 | Orthogroups_2024-Update | |
| HORVU0Hr1G018190.6 | No alias | Unknown function | 0.04 | Orthogroups_2024-Update | |
| HORVU6Hr1G030390.2 | No alias | p-coumarate | 0.08 | Orthogroups_2024-Update | |
| PSME_00015568-RA | No alias | (o24146|4cl2_tobac : 707.0) 4-coumarate--CoA ligase 2... | 0.04 | Orthogroups_2024-Update | |
| PSME_00015569-RA | No alias | (o24146|4cl2_tobac : 689.0) 4-coumarate--CoA ligase 2... | 0.06 | Orthogroups_2024-Update | |
| PSME_00022177-RA | No alias | (o24146|4cl2_tobac : 717.0) 4-coumarate--CoA ligase 2... | 0.12 | Orthogroups_2024-Update | |
| Potri.018G094200 | No alias | 4-coumarate:CoA ligase 2 | 0.03 | Orthogroups_2024-Update | |
| Pp1s167_96V6 | No alias | 4-coumarate:coenzyme a ligase 4 | 0.04 | Orthogroups_2024-Update | |
| Pp1s20_346V6 | No alias | 4-coumarate: ligase | 0.08 | Orthogroups_2024-Update | |
| Pp1s71_170V6 | No alias | 4-coumarate: ligase | 0.05 | Orthogroups_2024-Update | |
| Seita.1G065800.1 | No alias | p-coumarate | 0.03 | Orthogroups_2024-Update | |
| Seita.4G191500.1 | No alias | p-coumarate | 0.03 | Orthogroups_2024-Update | |
| Sobic.004G272700.1 | No alias | p-coumarate | 0.04 | Orthogroups_2024-Update |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| MF | GO:0003824 | catalytic activity | IEA | InterProScan predictions |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| MF | GO:0003849 | 3-deoxy-7-phosphoheptulonate synthase activity | IEP | Predicted GO |
| MF | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds | IEP | Predicted GO |
| MF | GO:0004564 | beta-fructofuranosidase activity | IEP | Predicted GO |
| MF | GO:0004575 | sucrose alpha-glucosidase activity | IEP | Predicted GO |
| BP | GO:0009072 | aromatic amino acid family metabolic process | IEP | Predicted GO |
| BP | GO:0009073 | aromatic amino acid family biosynthetic process | IEP | Predicted GO |
| MF | GO:0010181 | FMN binding | IEP | Predicted GO |
| MF | GO:0015926 | glucosidase activity | IEP | Predicted GO |
| MF | GO:0016491 | oxidoreductase activity | IEP | Predicted GO |
| MF | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups | IEP | Predicted GO |
| MF | GO:0016798 | hydrolase activity, acting on glycosyl bonds | IEP | Predicted GO |
| MF | GO:0016872 | intramolecular lyase activity | IEP | Predicted GO |
| MF | GO:0048037 | cofactor binding | IEP | Predicted GO |
| MF | GO:0050662 | coenzyme binding | IEP | Predicted GO |
| BP | GO:0055114 | oxidation-reduction process | IEP | Predicted GO |
| MF | GO:0090599 | alpha-glucosidase activity | IEP | Predicted GO |
| No external refs found! |