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Description : (at1g68760 : 170.0) Encodes a cytosol-localized nudix hydrolase that hydrolyzes 8-oxo-(d)GTP to its monophosphate form. This protective mechanism prevents the misincorporation of these oxidized nucleotides into DNA and RNA. NUDX1 also has a low level of dihydroneopterin triphosphate pyrophosphatase activity in vitro and may participate in the folate synthesis pathway.; nudix hydrolase 1 (NUDX1); FUNCTIONS IN: hydrolase activity, dihydroneopterin triphosphate pyrophosphohydrolase activity, 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity; INVOLVED IN: response to DNA damage stimulus; LOCATED IN: cytosol; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), NUDIX hydrolase (InterPro:IPR020476), NUDIX hydrolase, conserved site (InterPro:IPR020084), NUDIX hydrolase domain (InterPro:IPR000086); Has 6319 Blast hits to 6317 proteins in 1575 species: Archae - 191; Bacteria - 5327; Metazoa - 193; Fungi - 66; Plants - 51; Viruses - 14; Other Eukaryotes - 477 (source: NCBI BLink). & (reliability: 340.0) & (original description: no original description)
Gene families : OG_42_0008511 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0008511_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
| Type | Description | Actions |
|---|---|---|
| Neighborhood | Picea release: MA_11165g0010 | |
| Cluster | HCCA clusters: Cluster_198 |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| MF | GO:0016787 | hydrolase activity | IEA | InterProScan predictions |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| BP | GO:0000041 | transition metal ion transport | IEP | Predicted GO |
| MF | GO:0003677 | DNA binding | IEP | Predicted GO |
| MF | GO:0003690 | double-stranded DNA binding | IEP | Predicted GO |
| MF | GO:0003899 | DNA-directed 5'-3' RNA polymerase activity | IEP | Predicted GO |
| MF | GO:0005381 | iron ion transmembrane transporter activity | IEP | Predicted GO |
| BP | GO:0006351 | transcription, DNA-templated | IEP | Predicted GO |
| BP | GO:0006826 | iron ion transport | IEP | Predicted GO |
| MF | GO:0008757 | S-adenosylmethionine-dependent methyltransferase activity | IEP | Predicted GO |
| MF | GO:0008897 | holo-[acyl-carrier-protein] synthase activity | IEP | Predicted GO |
| MF | GO:0016740 | transferase activity | IEP | Predicted GO |
| MF | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups | IEP | Predicted GO |
| MF | GO:0016780 | phosphotransferase activity, for other substituted phosphate groups | IEP | Predicted GO |
| MF | GO:0034062 | 5'-3' RNA polymerase activity | IEP | Predicted GO |
| BP | GO:0034755 | iron ion transmembrane transport | IEP | Predicted GO |
| MF | GO:0046915 | transition metal ion transmembrane transporter activity | IEP | Predicted GO |
| BP | GO:0097659 | nucleic acid-templated transcription | IEP | Predicted GO |
| MF | GO:0097747 | RNA polymerase activity | IEP | Predicted GO |
| InterPro domains | Description | Start | Stop |
|---|---|---|---|
| IPR000086 | NUDIX_hydrolase_dom | 28 | 144 |
| No external refs found! |