MA_248329g0010

Description : (at4g13870 : 81.6) Encodes a protein with homology to the exonuclease domain of hWRN-p of human protein Werner Syndrome Exonuclease (WEX). Forms a complex with the heterodimeric factor Ku. The interaction with KU stimulates WEX exonuclease activity.; Werner syndrome-like exonuclease (WRNEXO); FUNCTIONS IN: protein binding, 3'-5' exonuclease activity, nucleic acid binding; INVOLVED IN: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; LOCATED IN: intracellular; CONTAINS InterPro DOMAIN/s: Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), 3'-5' exonuclease (InterPro:IPR002562); BEST Arabidopsis thaliana protein match is: Polynucleotidyl transferase, ribonuclease H-like superfamily protein (TAIR:AT4G13885.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink). & (reliability: 163.2) & (original description: no original description)

Gene families : OG_42_0000433 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000433_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Picea release: MA_248329g0010
Cluster	HCCA clusters: Cluster_58

Target	Alias	Description	ECC score	Gene Family Method
At3g12470	No alias	At3g12470 [Source:UniProtKB/TrEMBL;Acc:Q9LHG1]	0.03	Orthogroups_2024-Update
At3g62320	No alias	Polynucleotidyl transferase, ribonuclease H-like...	0.03	Orthogroups_2024-Update
LOC_Os04g03990	No alias	3-5 exonuclease domain-containing protein, putative, expressed	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	IEA	InterProScan predictions
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004518	nuclease activity	None	Extended
MF	GO:0004527	exonuclease activity	None	Extended
MF	GO:0005488	binding	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	IEA	InterProScan predictions
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008408	3'-5' exonuclease activity	IEA	InterProScan predictions
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016788	hydrolase activity, acting on ester bonds	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0001101	response to acid chemical	IEP	Predicted GO
MF	GO:0003743	translation initiation factor activity	IEP	Predicted GO
MF	GO:0004665	prephenate dehydrogenase (NADP+) activity	IEP	Predicted GO
CC	GO:0005811	lipid droplet	IEP	Predicted GO
BP	GO:0006413	translational initiation	IEP	Predicted GO
BP	GO:0006570	tyrosine metabolic process	IEP	Predicted GO
BP	GO:0006571	tyrosine biosynthetic process	IEP	Predicted GO
MF	GO:0008135	translation factor activity, RNA binding	IEP	Predicted GO
MF	GO:0008977	prephenate dehydrogenase (NAD+) activity	IEP	Predicted GO
BP	GO:0009072	aromatic amino acid family metabolic process	IEP	Predicted GO
BP	GO:0009073	aromatic amino acid family biosynthetic process	IEP	Predicted GO
BP	GO:0009095	aromatic amino acid family biosynthetic process, prephenate pathway	IEP	Predicted GO
BP	GO:0009415	response to water	IEP	Predicted GO
BP	GO:0009628	response to abiotic stimulus	IEP	Predicted GO
BP	GO:0010035	response to inorganic substance	IEP	Predicted GO
CC	GO:0012511	monolayer-surrounded lipid storage body	IEP	Predicted GO
MF	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	IEP	Predicted GO
MF	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	IEP	Predicted GO
BP	GO:1901700	response to oxygen-containing compound	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR002562	3'-5'_exonuclease_dom	2	146

External Links

No external refs found!

MA_248329g0010

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation