MA_62683g0010

Description : (at2g36910 : 1072.0) Belongs to the family of ATP-binding cassette (ABC) transporters. Also known as AtMDR1.Possibly regulates auxin-dependent responses by influencing basipetal auxin transport in the root. Exerts nonredundant, partially overlapping functions with the ABC transporter encoded by AT3G28860. PGP1 mediates cellular efflux of IAA and interacts with PIN genes that may confer an accelerated vectoral component to PGP-mediated transport. The non-polar localization of PGP1 at root and shoot apices, where IAA gradient-driven transport is impaired, may be required to confer directionality to auxin transport in those tissues.; ATP binding cassette subfamily B1 (ABCB1); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances, calmodulin binding, auxin efflux transmembrane transporter activity; INVOLVED IN: in 10 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: ATP binding cassette subfamily B19 (TAIR:AT3G28860.1); Has 825599 Blast hits to 386427 proteins in 4134 species: Archae - 14573; Bacteria - 644325; Metazoa - 17752; Fungi - 12077; Plants - 9020; Viruses - 35; Other Eukaryotes - 127817 (source: NCBI BLink). & (q6yuu5|mdr_orysa : 606.0) Putative multidrug resistance protein (P-glycoprotein) - Oryza sativa (Rice) & (reliability: 2144.0) & (original description: no original description)

Gene families : OG_42_0000040 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000040_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Picea release: MA_62683g0010
Cluster	HCCA clusters: Cluster_185

Target	Alias	Description	ECC score	Gene Family Method
AC233882.1_FG003	No alias	P-glycoprotein 11	0.04	Orthogroups_2024-Update
Bradi5g13617	No alias	ABC transporter family protein	0.03	Orthogroups_2024-Update
Brara.C01848.1	No alias	Unknown function	0.03	Orthogroups_2024-Update
Brara.D02299.1	No alias	subfamily ABCB transporter	0.03	Orthogroups_2024-Update
Brara.D02827.1	No alias	subfamily ABCB transporter	0.03	Orthogroups_2024-Update
GRMZM2G167658	No alias	ATP binding cassette subfamily B19	0.03	Orthogroups_2024-Update
Glyma.06G139500	No alias	ATP binding cassette subfamily B19	0.03	Orthogroups_2024-Update
Glyma.09G206300	No alias	P-glycoprotein 2	0.04	Orthogroups_2024-Update
Glyma.19G184300	No alias	ATP binding cassette subfamily B1	0.05	Orthogroups_2024-Update
HORVU6Hr1G067200.1	No alias	subfamily ABCB transporter	0.03	Orthogroups_2024-Update
HORVU7Hr1G063020.3	No alias	subfamily ABCB transporter	0.03	Orthogroups_2024-Update
Kfl00008_0360	kfl00008_0360_v1.1	(at1g02520 : 1200.0) P-glycoprotein 11 (PGP11);...	0.02	Orthogroups_2024-Update
Potri.010G210100	No alias	P-glycoprotein 20	0.02	Orthogroups_2024-Update
Potri.017G085000	No alias	ABC transporter family protein	0.04	Orthogroups_2024-Update
Seita.5G302200.1	No alias	subfamily ABCB transporter	0.03	Orthogroups_2024-Update
Seita.6G060300.1	No alias	subfamily ABCB transporter	0.03	Orthogroups_2024-Update
Sobic.003G180400.1	No alias	subfamily ABCB transporter	0.03	Orthogroups_2024-Update
Sobic.004G073600.1	No alias	subfamily ABCB transporter	0.03	Orthogroups_2024-Update
Sobic.007G042600.1	No alias	subfamily ABCB transporter	0.03	Orthogroups_2024-Update
Sopen04g005490	No alias	ABC transporter transmembrane region	0.03	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0005215	transporter activity	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005506	iron ion binding	IEA	InterProScan predictions
MF	GO:0005524	ATP binding	IEA	InterProScan predictions
CC	GO:0005575	cellular_component	None	Extended
BP	GO:0006810	transport	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0015399	primary active transmembrane transporter activity	None	Extended
MF	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	None	Extended
CC	GO:0016021	integral component of membrane	IEA	InterProScan predictions
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA	InterProScan predictions
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0016887	ATPase activity	IEA	InterProScan predictions
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0020037	heme binding	IEA	InterProScan predictions
MF	GO:0022804	active transmembrane transporter activity	None	Extended
MF	GO:0022857	transmembrane transporter activity	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
CC	GO:0031224	intrinsic component of membrane	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0042623	ATPase activity, coupled	None	Extended
MF	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	IEA	InterProScan predictions
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
MF	GO:0043492	ATPase activity, coupled to movement of substances	None	Extended
CC	GO:0044425	membrane part	None	Extended
MF	GO:0046872	metal ion binding	None	Extended
MF	GO:0046906	tetrapyrrole binding	None	Extended
MF	GO:0046914	transition metal ion binding	None	Extended
MF	GO:0048037	cofactor binding	None	Extended
BP	GO:0051179	localization	None	Extended
BP	GO:0051234	establishment of localization	None	Extended
BP	GO:0055085	transmembrane transport	IEA	InterProScan predictions
BP	GO:0055114	oxidation-reduction process	IEA	InterProScan predictions
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000271	polysaccharide biosynthetic process	IEP	Predicted GO
MF	GO:0004497	monooxygenase activity	IEP	Predicted GO
MF	GO:0004499	N,N-dimethylaniline monooxygenase activity	IEP	Predicted GO
BP	GO:0005976	polysaccharide metabolic process	IEP	Predicted GO
BP	GO:0006073	cellular glucan metabolic process	IEP	Predicted GO
MF	GO:0008194	UDP-glycosyltransferase activity	IEP	Predicted GO
BP	GO:0009250	glucan biosynthetic process	IEP	Predicted GO
CC	GO:0016020	membrane	IEP	Predicted GO
BP	GO:0016051	carbohydrate biosynthetic process	IEP	Predicted GO
MF	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IEP	Predicted GO
MF	GO:0016759	cellulose synthase activity	IEP	Predicted GO
MF	GO:0016760	cellulose synthase (UDP-forming) activity	IEP	Predicted GO
MF	GO:0016840	carbon-nitrogen lyase activity	IEP	Predicted GO
MF	GO:0016843	amine-lyase activity	IEP	Predicted GO
MF	GO:0016844	strictosidine synthase activity	IEP	Predicted GO
BP	GO:0030243	cellulose metabolic process	IEP	Predicted GO
BP	GO:0030244	cellulose biosynthetic process	IEP	Predicted GO
BP	GO:0033692	cellular polysaccharide biosynthetic process	IEP	Predicted GO
BP	GO:0034637	cellular carbohydrate biosynthetic process	IEP	Predicted GO
MF	GO:0035251	UDP-glucosyltransferase activity	IEP	Predicted GO
BP	GO:0044042	glucan metabolic process	IEP	Predicted GO
BP	GO:0044262	cellular carbohydrate metabolic process	IEP	Predicted GO
BP	GO:0044264	cellular polysaccharide metabolic process	IEP	Predicted GO
MF	GO:0046527	glucosyltransferase activity	IEP	Predicted GO
MF	GO:0050661	NADP binding	IEP	Predicted GO
BP	GO:0051273	beta-glucan metabolic process	IEP	Predicted GO
BP	GO:0051274	beta-glucan biosynthetic process	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR001128	Cyt_P450	1054	1119
IPR011527	ABC1_TM_dom	111	370
IPR011527	ABC1_TM_dom	700	860
IPR003439	ABC_transporter-like	411	536

External Links

No external refs found!

MA_62683g0010

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation