MA_6634g0010

Description : (o24308|top2_pea : 1595.0) DNA topoisomerase 2 (EC 5.99.1.3) (DNA topoisomerase II) (PsTopII) - Pisum sativum (Garden pea) & (at3g23890 : 1587.0) Encodes a topoisomerase II that is highly expressed in young seedlings. The protein is localized in the nucleus and gene expression levels are increased in proliferative tissues.; topoisomerase II (TOPII); CONTAINS InterPro DOMAIN/s: DNA topoisomerase, type IIA, subunit A/C-terminal (InterPro:IPR002205), DNA topoisomerase, type IIA, conserved site (InterPro:IPR018522), DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta (InterPro:IPR013758), DNA topoisomerase, type IIA, subunit B, domain 2 (InterPro:IPR013506), DNA topoisomerase, type IIA, subunit A, alpha-helical (InterPro:IPR013757), ATPase-like, ATP-binding domain (InterPro:IPR003594), DNA topoisomerase, type IIA, subunit B/N-terminal, alpha-beta (InterPro:IPR013759), DNA topoisomerase, type IIA, subunit B/N-terminal (InterPro:IPR001241), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), DNA topoisomerase II, eukaryotic-type (InterPro:IPR001154), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721), DNA topoisomerase, type IIA, central (InterPro:IPR013760); BEST Arabidopsis thaliana protein match is: DNA GYRASE B2 (TAIR:AT5G04130.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink). & (reliability: 3174.0) & (original description: no original description)

Gene families : OG_42_0003889 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0003889_tree

Sequence : coding (download), protein (download)

Attention: This gene has low abundance.

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Picea release: MA_6634g0010
Cluster	HCCA clusters: Cluster_39

Target	Alias	Description	ECC score	Gene Family Method
98330	No alias	topoisomerase II	0.04	Orthogroups_2024-Update
A4A49_12016	No alias	dna topoisomerase 2	0.07	Orthogroups_2024-Update
At3g23890	No alias	DNA topoisomerase 2 [Source:UniProtKB/Swiss-Prot;Acc:P30182]	0.06	Orthogroups_2024-Update
Brara.A00830.1	No alias	DNA topoisomerase *(TOP2)	0.1	Orthogroups_2024-Update
Cre01.g009250	No alias	topoisomerase II	0.02	Orthogroups_2024-Update
Glyma.10G090000	No alias	topoisomerase II	0.11	Orthogroups_2024-Update
Glyma.15G276000	No alias	topoisomerase II	0.1	Orthogroups_2024-Update
Kfl00053_0310	kfl00053_0310_v1.1	(o24308\|top2_pea : 1259.0) DNA topoisomerase 2 (EC...	0.05	Orthogroups_2024-Update
Mp3g13420.1	No alias	DNA topoisomerase (TOP2)	0.06	Orthogroups_2024-Update
PSME_00008874-RA	No alias	(at3g23890 : 1554.0) Encodes a topoisomerase II that is...	0.03	Orthogroups_2024-Update
PSME_00016559-RA	No alias	(o24308\|top2_pea : 1626.0) DNA topoisomerase 2 (EC...	0.04	Orthogroups_2024-Update
Pp1s33_203V6	No alias	dna topoisomerase ii	0.02	Orthogroups_2024-Update
Solyc01g087500	No alias	DNA topoisomerase 2 (AHRD V3.3 *** K4AYE0_SOLLC)	0.1	Orthogroups_2024-Update
evm.model.contig_3477.2	No alias	(at3g23890 : 1176.0) Encodes a topoisomerase II that is...	0.05	Orthogroups_2024-Update
evm.model.tig00021432.55	No alias	(o24308\|top2_pea : 775.0) DNA topoisomerase 2 (EC...	0.03	Orthogroups_2024-Update
evm.model.tig00021433.1	No alias	(at3g23890 : 211.0) Encodes a topoisomerase II that is...	0.03	Orthogroups_2024-Update
evm.model.tig00021433.2	No alias	(at3g23890 : 475.0) Encodes a topoisomerase II that is...	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	InterProScan predictions
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003916	DNA topoisomerase activity	None	Extended
MF	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	InterProScan predictions
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006265	DNA topological change	IEA	InterProScan predictions
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006996	organelle organization	None	Extended
MF	GO:0008094	DNA-dependent ATPase activity	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016043	cellular component organization	None	Extended
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0016853	isomerase activity	None	Extended
MF	GO:0016887	ATPase activity	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0042623	ATPase activity, coupled	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0051276	chromosome organization	None	Extended
MF	GO:0061505	DNA topoisomerase II activity	None	Extended
BP	GO:0071103	DNA conformation change	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0071840	cellular component organization or biogenesis	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
CC	GO:0000786	nucleosome	IEP	Predicted GO
CC	GO:0000808	origin recognition complex	IEP	Predicted GO
MF	GO:0003774	motor activity	IEP	Predicted GO
MF	GO:0003777	microtubule motor activity	IEP	Predicted GO
MF	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	IEP	Predicted GO
MF	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEP	Predicted GO
CC	GO:0005634	nucleus	IEP	Predicted GO
BP	GO:0005975	carbohydrate metabolic process	IEP	Predicted GO
BP	GO:0006260	DNA replication	IEP	Predicted GO
BP	GO:0006270	DNA replication initiation	IEP	Predicted GO
BP	GO:0006275	regulation of DNA replication	IEP	Predicted GO
BP	GO:0006928	movement of cell or subcellular component	IEP	Predicted GO
BP	GO:0007017	microtubule-based process	IEP	Predicted GO
BP	GO:0007018	microtubule-based movement	IEP	Predicted GO
MF	GO:0008017	microtubule binding	IEP	Predicted GO
MF	GO:0008092	cytoskeletal protein binding	IEP	Predicted GO
MF	GO:0015631	tubulin binding	IEP	Predicted GO
MF	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	IEP	Predicted GO
MF	GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	IEP	Predicted GO
MF	GO:0016798	hydrolase activity, acting on glycosyl bonds	IEP	Predicted GO
CC	GO:0032993	protein-DNA complex	IEP	Predicted GO
CC	GO:0043226	organelle	IEP	Predicted GO
CC	GO:0043227	membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043229	intracellular organelle	IEP	Predicted GO
CC	GO:0043231	intracellular membrane-bounded organelle	IEP	Predicted GO
CC	GO:0044422	organelle part	IEP	Predicted GO
CC	GO:0044424	intracellular part	IEP	Predicted GO
CC	GO:0044427	chromosomal part	IEP	Predicted GO
CC	GO:0044446	intracellular organelle part	IEP	Predicted GO
CC	GO:0044464	cell part	IEP	Predicted GO
CC	GO:0044815	DNA packaging complex	IEP	Predicted GO
BP	GO:0051052	regulation of DNA metabolic process	IEP	Predicted GO
MF	GO:0061731	ribonucleoside-diphosphate reductase activity	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR013506	Topo_IIA_bsu_dom2	270	425
IPR002205	Topo_IIA_A/C	697	1144
IPR003594	HATPase_C	78	222
IPR006171	TOPRIM_domain	456	554
IPR031660	TOPRIM_C	570	696

External Links

No external refs found!

MA_6634g0010

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation