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Description : (at3g06483 : 92.0) Pyruvate dehydrogenase kinase (PDK) specifically phosphorylates the E1α subunit of the pyruvate dehydrogenase complex (PDC) on a Ser residue using ATP as a phosphate donor. PDK is a unique type of protein kinase having a His-kinase-like sequence but Ser-kinase activity. Site-directed mutagenesis and structural analysis indicate that PDK belongs to the GHKL superfamily.; pyruvate dehydrogenase kinase (PDK); FUNCTIONS IN: ATP binding, pyruvate dehydrogenase (acetyl-transferring) kinase activity, histidine phosphotransfer kinase activity; INVOLVED IN: signal transduction, peptidyl-histidine phosphorylation, phosphorylation; LOCATED IN: mitochondrion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, core (InterPro:IPR005467), Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, mitochondrial (InterPro:IPR018955), ATPase-like, ATP-binding domain (InterPro:IPR003594), Signal transduction histidine kinase-related protein, C-terminal (InterPro:IPR004358); Has 1925 Blast hits to 1799 proteins in 531 species: Archae - 0; Bacteria - 712; Metazoa - 467; Fungi - 468; Plants - 102; Viruses - 0; Other Eukaryotes - 176 (source: NCBI BLink). & (reliability: 184.0) & (original description: no original description)
Gene families : OG_42_0120892 (Orthogroups_2024-Update) Phylogenetic Tree(s): No tree available for this family
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
| Type | Description | Actions |
|---|---|---|
| Neighborhood | Picea release: MA_9774183g0010 | |
| Cluster | HCCA clusters: Cluster_44 |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
No GO annotation available for this sequence |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| MF | GO:0004417 | hydroxyethylthiazole kinase activity | IEP | Predicted GO |
| BP | GO:0006766 | vitamin metabolic process | IEP | Predicted GO |
| BP | GO:0006767 | water-soluble vitamin metabolic process | IEP | Predicted GO |
| BP | GO:0006772 | thiamine metabolic process | IEP | Predicted GO |
| BP | GO:0006790 | sulfur compound metabolic process | IEP | Predicted GO |
| BP | GO:0009110 | vitamin biosynthetic process | IEP | Predicted GO |
| BP | GO:0009228 | thiamine biosynthetic process | IEP | Predicted GO |
| BP | GO:0042364 | water-soluble vitamin biosynthetic process | IEP | Predicted GO |
| BP | GO:0042723 | thiamine-containing compound metabolic process | IEP | Predicted GO |
| BP | GO:0042724 | thiamine-containing compound biosynthetic process | IEP | Predicted GO |
| MF | GO:0043531 | ADP binding | IEP | Predicted GO |
| BP | GO:0044272 | sulfur compound biosynthetic process | IEP | Predicted GO |
| BP | GO:0072527 | pyrimidine-containing compound metabolic process | IEP | Predicted GO |
| BP | GO:0072528 | pyrimidine-containing compound biosynthetic process | IEP | Predicted GO |
No InterPro domains available for this sequence
| No external refs found! |