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- evm.model.contig_2176.1
evm.model.contig_2176.1
Description : (at4g02070 : 315.0) encodes a DNA mismatch repair homolog of human MutS gene, MSH6. There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2*MSH6 bound the (+T) substrate strongly, (T/G) well, and (+AAG) no better than it did a (T/A) homoduplex.; MUTS homolog 6 (MSH6); FUNCTIONS IN: damaged DNA binding; INVOLVED IN: mismatch repair; LOCATED IN: chloroplast; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein Msh6 (InterPro:IPR017261), DNA mismatch repair protein MutS, clamp (InterPro:IPR007861), DNA mismatch repair protein MutS, connector (InterPro:IPR007860), DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695), DNA mismatch repair protein MutS, N-terminal (InterPro:IPR016151), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-homologue MSH6 (InterPro:IPR015536), Tudor domain (InterPro:IPR002999); BEST Arabidopsis thaliana protein match is: homolog of DNA mismatch repair protein MSH3 (TAIR:AT4G25540.1). & (q9xgc9|msh2_maize : 162.0) DNA mismatch repair protein MSH2 (MUS1) - Zea mays (Maize) & (reliability: 630.0) & (original description: no original description)
Expression Profile
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Co-expression Networks
| Type | Description | Actions |
| Neighborhood | Porphyridium release: evm.model.contig_2176.1 | |
| Cluster | HCCA clusters: Cluster_45 | |
Expression Context Conservation (ECC)
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
| Kfl00153_0160 | kfl00153_0160_v1.1 | (at4g02070 : 834.0) encodes a DNA mismatch repair... | 0.03 | Orthogroups_2024-Update | |
| Seita.2G201300.1 | No alias | component *(MSH6) of MSH2-x mismatch repair heterodimers | 0.02 | Orthogroups_2024-Update | |
| evm.model.tig00000489.16 | No alias | (at4g02070 : 188.0) encodes a DNA mismatch repair... | 0.02 | Orthogroups_2024-Update | |
Functional Annotation
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0000166 | nucleotide binding | None | Extended |
| MF | GO:0003674 | molecular_function | None | Extended |
| MF | GO:0003676 | nucleic acid binding | None | Extended |
| MF | GO:0003677 | DNA binding | None | Extended |
| MF | GO:0003690 | double-stranded DNA binding | None | Extended |
| MF | GO:0005488 | binding | None | Extended |
| MF | GO:0005524 | ATP binding | IEA | InterProScan predictions |
| BP | GO:0006139 | nucleobase-containing compound metabolic process | None | Extended |
| BP | GO:0006259 | DNA metabolic process | None | Extended |
| BP | GO:0006281 | DNA repair | None | Extended |
| BP | GO:0006298 | mismatch repair | IEA | InterProScan predictions |
| BP | GO:0006725 | cellular aromatic compound metabolic process | None | Extended |
| BP | GO:0006807 | nitrogen compound metabolic process | None | Extended |
| BP | GO:0006950 | response to stress | None | Extended |
| BP | GO:0006974 | cellular response to DNA damage stimulus | None | Extended |
| MF | GO:0008144 | drug binding | None | Extended |
| BP | GO:0008150 | biological_process | None | Extended |
| BP | GO:0008152 | metabolic process | None | Extended |
| BP | GO:0009987 | cellular process | None | Extended |
| MF | GO:0017076 | purine nucleotide binding | None | Extended |
| MF | GO:0030554 | adenyl nucleotide binding | None | Extended |
| MF | GO:0030983 | mismatched DNA binding | IEA | InterProScan predictions |
| MF | GO:0032553 | ribonucleotide binding | None | Extended |
| MF | GO:0032555 | purine ribonucleotide binding | None | Extended |
| MF | GO:0032559 | adenyl ribonucleotide binding | None | Extended |
| BP | GO:0033554 | cellular response to stress | None | Extended |
| BP | GO:0034641 | cellular nitrogen compound metabolic process | None | Extended |
| MF | GO:0035639 | purine ribonucleoside triphosphate binding | None | Extended |
| MF | GO:0036094 | small molecule binding | None | Extended |
| MF | GO:0043167 | ion binding | None | Extended |
| MF | GO:0043168 | anion binding | None | Extended |
| BP | GO:0043170 | macromolecule metabolic process | None | Extended |
| BP | GO:0044237 | cellular metabolic process | None | Extended |
| BP | GO:0044238 | primary metabolic process | None | Extended |
| BP | GO:0044260 | cellular macromolecule metabolic process | None | Extended |
| BP | GO:0046483 | heterocycle metabolic process | None | Extended |
| BP | GO:0050896 | response to stimulus | None | Extended |
| BP | GO:0051716 | cellular response to stimulus | None | Extended |
| BP | GO:0071704 | organic substance metabolic process | None | Extended |
| BP | GO:0090304 | nucleic acid metabolic process | None | Extended |
| MF | GO:0097159 | organic cyclic compound binding | None | Extended |
| MF | GO:0097367 | carbohydrate derivative binding | None | Extended |
| MF | GO:1901265 | nucleoside phosphate binding | None | Extended |
| BP | GO:1901360 | organic cyclic compound metabolic process | None | Extended |
| MF | GO:1901363 | heterocyclic compound binding | None | Extended |
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0003689 | DNA clamp loader activity | IEP | Predicted GO |
| MF | GO:0003723 | RNA binding | IEP | Predicted GO |
| MF | GO:0003743 | translation initiation factor activity | IEP | Predicted GO |
| MF | GO:0003909 | DNA ligase activity | IEP | Predicted GO |
| MF | GO:0003910 | DNA ligase (ATP) activity | IEP | Predicted GO |
| MF | GO:0003916 | DNA topoisomerase activity | IEP | Predicted GO |
| CC | GO:0005634 | nucleus | IEP | Predicted GO |
| CC | GO:0005663 | DNA replication factor C complex | IEP | Predicted GO |
| CC | GO:0005694 | chromosome | IEP | Predicted GO |
| BP | GO:0006265 | DNA topological change | IEP | Predicted GO |
| BP | GO:0006310 | DNA recombination | IEP | Predicted GO |
| BP | GO:0006333 | chromatin assembly or disassembly | IEP | Predicted GO |
| BP | GO:0006413 | translational initiation | IEP | Predicted GO |
| BP | GO:0006996 | organelle organization | IEP | Predicted GO |
| MF | GO:0008135 | translation factor activity, RNA binding | IEP | Predicted GO |
| BP | GO:0016043 | cellular component organization | IEP | Predicted GO |
| MF | GO:0016886 | ligase activity, forming phosphoric ester bonds | IEP | Predicted GO |
| MF | GO:0033170 | protein-DNA loading ATPase activity | IEP | Predicted GO |
| CC | GO:0043226 | organelle | IEP | Predicted GO |
| CC | GO:0043227 | membrane-bounded organelle | IEP | Predicted GO |
| CC | GO:0043229 | intracellular organelle | IEP | Predicted GO |
| CC | GO:0043231 | intracellular membrane-bounded organelle | IEP | Predicted GO |
| BP | GO:0051276 | chromosome organization | IEP | Predicted GO |
| BP | GO:0071103 | DNA conformation change | IEP | Predicted GO |
| BP | GO:0071840 | cellular component organization or biogenesis | IEP | Predicted GO |
| MF | GO:0140097 | catalytic activity, acting on DNA | IEP | Predicted GO |
| InterPro domains | Description | Start | Stop |
| IPR007696 | DNA_mismatch_repair_MutS_core | 779 | 1135 |
| IPR000432 | DNA_mismatch_repair_MutS_C | 1211 | 1401 |
| IPR007861 | DNA_mismatch_repair_MutS_clamp | 996 | 1094 |
| IPR007860 | DNA_mmatch_repair_MutS_con_dom | 551 | 597 |
| IPR007695 | DNA_mismatch_repair_MutS-lik_N | 385 | 498 |
