Description : (at1g22940 : 147.0) Encodes a bifunctional enzyme required for thiamine (vitamin B1) biosynthesis. TH1 can phosphorylate HMP-P to produce HMP-PP, the pyrimidine heterocyclic subunit of thiamine. TH1 also catalyzes the condensation of HMP-PP and HET to form thiamine monophosphate (TMP). TH1 also appears capable of phosphorylating HMP based on E.coli mutant complementation assays. th1 mutants are thiamine auxotrophs that die as seedlings on unsupplemented media.; THIAMINE REQUIRING 1 (TH1); FUNCTIONS IN: phosphomethylpyrimidine kinase activity, thiamin-phosphate diphosphorylase activity, hydroxymethylpyrimidine kinase activity; INVOLVED IN: thiamin biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiamine monophosphate synthase (InterPro:IPR003733), Phosphomethylpyrimidine kinase type-2 (InterPro:IPR004399), Aldolase-type TIM barrel (InterPro:IPR013785), Phosphomethylpyrimidine kinase type-1 (InterPro:IPR013749); Has 15989 Blast hits to 15891 proteins in 2548 species: Archae - 338; Bacteria - 12149; Metazoa - 165; Fungi - 331; Plants - 107; Viruses - 0; Other Eukaryotes - 2899 (source: NCBI BLink). & (reliability: 294.0) & (original description: no original description)
Gene families : OG_42_0005927 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0005927_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | Porphyridium release: evm.model.contig_447.2 | |
Cluster | HCCA clusters: Cluster_59 |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No GO annotation available for this sequence |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity | IEP | Predicted GO |
BP | GO:0006629 | lipid metabolic process | IEP | Predicted GO |
BP | GO:0006694 | steroid biosynthetic process | IEP | Predicted GO |
BP | GO:0006793 | phosphorus metabolic process | IEP | Predicted GO |
BP | GO:0006796 | phosphate-containing compound metabolic process | IEP | Predicted GO |
BP | GO:0008202 | steroid metabolic process | IEP | Predicted GO |
BP | GO:0008610 | lipid biosynthetic process | IEP | Predicted GO |
BP | GO:0008654 | phospholipid biosynthetic process | IEP | Predicted GO |
BP | GO:0009966 | regulation of signal transduction | IEP | Predicted GO |
BP | GO:0010646 | regulation of cell communication | IEP | Predicted GO |
MF | GO:0016229 | steroid dehydrogenase activity | IEP | Predicted GO |
MF | GO:0016772 | transferase activity, transferring phosphorus-containing groups | IEP | Predicted GO |
MF | GO:0016780 | phosphotransferase activity, for other substituted phosphate groups | IEP | Predicted GO |
BP | GO:0023051 | regulation of signaling | IEP | Predicted GO |
MF | GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IEP | Predicted GO |
BP | GO:0048583 | regulation of response to stimulus | IEP | Predicted GO |
InterPro domains | Description | Start | Stop |
---|---|---|---|
IPR022998 | ThiamineP_synth_TenI | 44 | 231 |
No external refs found! |