evm.model.contig_447.2


Description : (at1g22940 : 147.0) Encodes a bifunctional enzyme required for thiamine (vitamin B1) biosynthesis. TH1 can phosphorylate HMP-P to produce HMP-PP, the pyrimidine heterocyclic subunit of thiamine. TH1 also catalyzes the condensation of HMP-PP and HET to form thiamine monophosphate (TMP). TH1 also appears capable of phosphorylating HMP based on E.coli mutant complementation assays. th1 mutants are thiamine auxotrophs that die as seedlings on unsupplemented media.; THIAMINE REQUIRING 1 (TH1); FUNCTIONS IN: phosphomethylpyrimidine kinase activity, thiamin-phosphate diphosphorylase activity, hydroxymethylpyrimidine kinase activity; INVOLVED IN: thiamin biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiamine monophosphate synthase (InterPro:IPR003733), Phosphomethylpyrimidine kinase type-2 (InterPro:IPR004399), Aldolase-type TIM barrel (InterPro:IPR013785), Phosphomethylpyrimidine kinase type-1 (InterPro:IPR013749); Has 15989 Blast hits to 15891 proteins in 2548 species: Archae - 338; Bacteria - 12149; Metazoa - 165; Fungi - 331; Plants - 107; Viruses - 0; Other Eukaryotes - 2899 (source: NCBI BLink). & (reliability: 294.0) & (original description: no original description)


Gene families : OG_42_0005927 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0005927_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Porphyridium release: evm.model.contig_447.2
Cluster HCCA clusters: Cluster_59


Type GO Term Name Evidence Source

No GO annotation available for this sequence

Type GO Term Name Evidence Source
MF GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity IEP Predicted GO
BP GO:0006629 lipid metabolic process IEP Predicted GO
BP GO:0006694 steroid biosynthetic process IEP Predicted GO
BP GO:0006793 phosphorus metabolic process IEP Predicted GO
BP GO:0006796 phosphate-containing compound metabolic process IEP Predicted GO
BP GO:0008202 steroid metabolic process IEP Predicted GO
BP GO:0008610 lipid biosynthetic process IEP Predicted GO
BP GO:0008654 phospholipid biosynthetic process IEP Predicted GO
BP GO:0009966 regulation of signal transduction IEP Predicted GO
BP GO:0010646 regulation of cell communication IEP Predicted GO
MF GO:0016229 steroid dehydrogenase activity IEP Predicted GO
MF GO:0016772 transferase activity, transferring phosphorus-containing groups IEP Predicted GO
MF GO:0016780 phosphotransferase activity, for other substituted phosphate groups IEP Predicted GO
BP GO:0023051 regulation of signaling IEP Predicted GO
MF GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEP Predicted GO
BP GO:0048583 regulation of response to stimulus IEP Predicted GO
InterPro domains Description Start Stop
IPR022998 ThiamineP_synth_TenI 44 231
No external refs found!