Description : (at3g06483 : 489.0) Pyruvate dehydrogenase kinase (PDK) specifically phosphorylates the E1α subunit of the pyruvate dehydrogenase complex (PDC) on a Ser residue using ATP as a phosphate donor. PDK is a unique type of protein kinase having a His-kinase-like sequence but Ser-kinase activity. Site-directed mutagenesis and structural analysis indicate that PDK belongs to the GHKL superfamily.; pyruvate dehydrogenase kinase (PDK); FUNCTIONS IN: ATP binding, pyruvate dehydrogenase (acetyl-transferring) kinase activity, histidine phosphotransfer kinase activity; INVOLVED IN: signal transduction, peptidyl-histidine phosphorylation, phosphorylation; LOCATED IN: mitochondrion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, core (InterPro:IPR005467), Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, mitochondrial (InterPro:IPR018955), ATPase-like, ATP-binding domain (InterPro:IPR003594), Signal transduction histidine kinase-related protein, C-terminal (InterPro:IPR004358); Has 1925 Blast hits to 1799 proteins in 531 species: Archae - 0; Bacteria - 712; Metazoa - 467; Fungi - 468; Plants - 102; Viruses - 0; Other Eukaryotes - 176 (source: NCBI BLink). & (reliability: 978.0) & (original description: no original description)
Gene families : OG_42_0003838 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0003838_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
| Type | Description | Actions |
|---|---|---|
| Neighborhood | Pseudotsuga release: PSME_00005016-RA | |
| Cluster | HCCA clusters: Cluster_148 |
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
|---|---|---|---|---|---|
| Brara.E03278.1 | No alias | pyruvate dehydrogenase kinase & EC_2.7 transferase... | 0.03 | Orthogroups_2024-Update | |
| Cre06.g278451 | No alias | pyruvate dehydrogenase kinase | 0.01 | Orthogroups_2024-Update | |
| LOC_Os07g44330 | No alias | kinase, putative, expressed | 0.02 | Orthogroups_2024-Update | |
| Seita.2G405900.1 | No alias | pyruvate dehydrogenase kinase & EC_2.7 transferase... | 0.05 | Orthogroups_2024-Update | |
| Sobic.002G390500.1 | No alias | pyruvate dehydrogenase kinase & EC_2.7 transferase... | 0.05 | Orthogroups_2024-Update |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
No GO annotation available for this sequence |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| MF | GO:0003830 | beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity | IEP | Predicted GO |
| MF | GO:0004089 | carbonate dehydratase activity | IEP | Predicted GO |
| MF | GO:0005319 | lipid transporter activity | IEP | Predicted GO |
| MF | GO:0005506 | iron ion binding | IEP | Predicted GO |
| BP | GO:0006487 | protein N-linked glycosylation | IEP | Predicted GO |
| BP | GO:0006869 | lipid transport | IEP | Predicted GO |
| MF | GO:0008289 | lipid binding | IEP | Predicted GO |
| MF | GO:0008375 | acetylglucosaminyltransferase activity | IEP | Predicted GO |
| BP | GO:0016052 | carbohydrate catabolic process | IEP | Predicted GO |
| BP | GO:0019725 | cellular homeostasis | IEP | Predicted GO |
| BP | GO:0042592 | homeostatic process | IEP | Predicted GO |
| BP | GO:0045454 | cell redox homeostasis | IEP | Predicted GO |
| BP | GO:0050789 | regulation of biological process | IEP | Predicted GO |
| BP | GO:0050794 | regulation of cellular process | IEP | Predicted GO |
| BP | GO:0061024 | membrane organization | IEP | Predicted GO |
| MF | GO:0061630 | ubiquitin protein ligase activity | IEP | Predicted GO |
| MF | GO:0061659 | ubiquitin-like protein ligase activity | IEP | Predicted GO |
| BP | GO:0065007 | biological regulation | IEP | Predicted GO |
| BP | GO:0120009 | intermembrane lipid transfer | IEP | Predicted GO |
| MF | GO:0120013 | intermembrane lipid transfer activity | IEP | Predicted GO |
| MF | GO:0140103 | catalytic activity, acting on a glycoprotein | IEP | Predicted GO |
| No external refs found! |