PSME_00006683-RA

Description : (p28002|comt1_medsa : 441.0) Caffeic acid 3-O-methyltransferase (EC 2.1.1.68) (S-adenosysl-L-methionine:caffeic acid 3-O-methyltransferase) (COMT) (CAOMT) - Medicago sativa (Alfalfa) & (at5g54160 : 426.0) A caffeic acid/5-hydroxyferulic acid O-methyltransferase. Interacts with 14-4-3 proteins in yeast 2 hybrid assay. AtOMT1 (At5g54160) encodes a flavonol 3Ã-O-methyltransferase that is highly active towards quercetin and myricetin. The substrate specificity identifies the enzyme as flavonol 3Ã-methyltransferase which replaces the former annotation of the gene to encode a caffeic acid/5-hydroxyferulic acid O-methyltransferase; O-methyltransferase 1 (OMT1); FUNCTIONS IN: myricetin 3'-O-methyltransferase activity, quercetin 3-O-methyltransferase activity, caffeate O-methyltransferase activity; INVOLVED IN: lignin biosynthetic process, flavonol biosynthetic process; LOCATED IN: cytosol, nucleus, plasma membrane, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Plant methyltransferase dimerisation (InterPro:IPR012967), O-methyltransferase, family 2 (InterPro:IPR001077), O-methyltransferase, COMT, eukaryota (InterPro:IPR016461); BEST Arabidopsis thaliana protein match is: O-methyltransferase family protein (TAIR:AT1G77520.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink). & (reliability: 852.0) & (original description: no original description)

Gene families : OG_42_0000016 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000016_tree

Sequence : coding (download), protein (download)

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Type	Description	Actions
Neighborhood	Pseudotsuga release: PSME_00006683-RA
Cluster	HCCA clusters: Cluster_239

Target	Alias	Description	ECC score	Gene Family Method
Bradi1g22757	No alias	O-methyltransferase family protein	0.03	Orthogroups_2024-Update
LOC_Os07g27880	No alias	O-methyltransferase, putative, expressed	0.02	Orthogroups_2024-Update
LOC_Os10g02840	No alias	O-methyltransferase, putative, expressed	0.02	Orthogroups_2024-Update
LOC_Os11g19840	No alias	O-methyltransferase, putative, expressed	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	None	Extended
MF	GO:0008168	methyltransferase activity	None	Extended
MF	GO:0008171	O-methyltransferase activity	IEA	InterProScan predictions
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016741	transferase activity, transferring one-carbon groups	None	Extended
MF	GO:0046983	protein dimerization activity	IEA	InterProScan predictions

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Type	GO Term	Name	Evidence	Source
MF	GO:0000155	phosphorelay sensor kinase activity	IEP	Predicted GO
BP	GO:0000726	non-recombinational repair	IEP	Predicted GO
MF	GO:0003677	DNA binding	IEP	Predicted GO
MF	GO:0003682	chromatin binding	IEP	Predicted GO
MF	GO:0004525	ribonuclease III activity	IEP	Predicted GO
MF	GO:0004672	protein kinase activity	IEP	Predicted GO
MF	GO:0004673	protein histidine kinase activity	IEP	Predicted GO
BP	GO:0006139	nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006302	double-strand break repair	IEP	Predicted GO
BP	GO:0006303	double-strand break repair via nonhomologous end joining	IEP	Predicted GO
BP	GO:0006725	cellular aromatic compound metabolic process	IEP	Predicted GO
BP	GO:0006886	intracellular protein transport	IEP	Predicted GO
BP	GO:0008104	protein localization	IEP	Predicted GO
MF	GO:0008408	3'-5' exonuclease activity	IEP	Predicted GO
BP	GO:0015031	protein transport	IEP	Predicted GO
BP	GO:0015833	peptide transport	IEP	Predicted GO
BP	GO:0015969	guanosine tetraphosphate metabolic process	IEP	Predicted GO
BP	GO:0016192	vesicle-mediated transport	IEP	Predicted GO
MF	GO:0016301	kinase activity	IEP	Predicted GO
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	IEP	Predicted GO
MF	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	IEP	Predicted GO
CC	GO:0030117	membrane coat	IEP	Predicted GO
MF	GO:0032296	double-stranded RNA-specific ribonuclease activity	IEP	Predicted GO
BP	GO:0033036	macromolecule localization	IEP	Predicted GO
BP	GO:0033865	nucleoside bisphosphate metabolic process	IEP	Predicted GO
BP	GO:0033875	ribonucleoside bisphosphate metabolic process	IEP	Predicted GO
BP	GO:0034032	purine nucleoside bisphosphate metabolic process	IEP	Predicted GO
BP	GO:0034035	purine ribonucleoside bisphosphate metabolic process	IEP	Predicted GO
BP	GO:0042278	purine nucleoside metabolic process	IEP	Predicted GO
BP	GO:0042886	amide transport	IEP	Predicted GO
BP	GO:0045184	establishment of protein localization	IEP	Predicted GO
BP	GO:0046128	purine ribonucleoside metabolic process	IEP	Predicted GO
BP	GO:0046483	heterocycle metabolic process	IEP	Predicted GO
BP	GO:0046907	intracellular transport	IEP	Predicted GO
BP	GO:0051641	cellular localization	IEP	Predicted GO
BP	GO:0051649	establishment of localization in cell	IEP	Predicted GO
CC	GO:0098796	membrane protein complex	IEP	Predicted GO
BP	GO:1901068	guanosine-containing compound metabolic process	IEP	Predicted GO
BP	GO:1901360	organic cyclic compound metabolic process	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR012967	Plant_MeTrfase_dimerisation	37	88
IPR001077	O_MeTrfase_2	143	347

External Links

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PSME_00006683-RA

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation