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  5. PSME_00010718-RA

PSME_00010718-RA


Description : (at4g22970 : 775.0) Encodes a separase (ESP), homologous to human and mouse separase protein. Separase is a capase family protease required for the release of sister chromatid cohesion during meiosis and mitosis. Arabidopsis separase contains a predicted 2Fe2S-ferredoxin domain that is not present in the proteins of other organisms. Also contains a putative EF-hand calcium binding domain. Mutant seeds exhibited embryo arrest at the globular stage. The endosperm also exhibited a weak titan-like phenotype. Transgenic plants expressing AESP RNA interference (RNAi) from the meiosis-specific DMC1 promoter exhibited alterations in chromosome segregation during meiosis I and II that resulted in polyads containing from one to eight microspores. Plays an essential role in embryo development. Required for the removal of cohesin from meiotic chromosomes and establishment of meiotic nuclear domains. This gene was also identified through the rsw4 mutant. Lines carrying recessive, temperature-sensitive mutations exhibit reduced anisotropic growth at 30 degrees Celsius. Microtubules and cellulose microfibrils are not depleted or disoriented in the mutants at the restrictive temperature.; homolog of separase (ESP); FUNCTIONS IN: peptidase activity; INVOLVED IN: meiotic chromosome separation, chromosome separation, embryo development ending in seed dormancy, positive regulation of sister chromatid cohesion, endosperm development; LOCATED IN: nucleus; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C50, separase (InterPro:IPR005314); BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT5G28550.1). & (reliability: 1550.0) & (original description: no original description)


Gene families : OG_42_0004157 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0004157_tree

Sequence : coding (download), protein (download)


Attention: This gene has low abundance.


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Pseudotsuga release: PSME_00010718-RA
Cluster HCCA clusters: Cluster_168

Target Alias Description ECC score Gene Family Method Actions
GRMZM2G300624 No alias homolog of separase 0.03 Orthogroups_2024-Update
Sobic.004G095200.1 No alias protease separase *(AESP) & separase *(ESP1) 0.04 Orthogroups_2024-Update
evm.model.contig_2500.8 No alias (at4g22970 : 114.0) Encodes a separase (ESP), homologous... 0.01 Orthogroups_2024-Update

Type GO Term Name Evidence Source

No GO annotation available for this sequence
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Type GO Term Name Evidence Source
BP GO:0006281 DNA repair IEP Predicted GO
MF GO:0008641 ubiquitin-like modifier activating enzyme activity IEP Predicted GO
MF GO:0016877 ligase activity, forming carbon-sulfur bonds IEP Predicted GO

No InterPro domains available for this sequence

No external refs found!