PSME_00021046-RA

Description : (at5g13960 : 630.0) Encodes a histone 3 lysine 9 specific methyltransferase involved in the maintenance of DNA methylation. SUVH4/KYP is a SU(VAR)3-9 homolog, a SET domain protein. Known SET domain proteins are involved in epigenetic control of gene expression. There are 10 SUVH genes in Arabidopsis and members of this subfamily of the SET proteins have an additional conserved SRA domain. In kyp mutants, there is a loss of CpNpG methylation. The protein was shown to bind to methylated cytosines of CG, CNG and CNN motifs via its SRA domain but has a preference for the latter two. There is also evidence that KYP/SUVH4 might be involved in the telomerase-independent process known as Alternative Lengthening of Telomeres.; SU(VAR)3-9 homolog 4 (SUVH4); FUNCTIONS IN: double-stranded methylated DNA binding, methyl-CpNpG binding, methyl-CpG binding, histone methyltransferase activity (H3-K9 specific), methyl-CpNpN binding; INVOLVED IN: maintenance of DNA methylation, histone methylation, peptidyl-lysine methylation, histone H3-K9 methylation; LOCATED IN: nucleus; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), SRA-YDG (InterPro:IPR003105), Pre-SET domain (InterPro:IPR007728), Post-SET domain (InterPro:IPR003616); BEST Arabidopsis thaliana protein match is: SU(VAR)3-9 homolog 6 (TAIR:AT2G22740.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink). & (reliability: 1260.0) & (original description: no original description)

Gene families : OG_42_0000288 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000288_tree

Sequence : coding (download), protein (download)

Attention: This gene has low abundance.

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pseudotsuga release: PSME_00021046-RA
Cluster	HCCA clusters: Cluster_86

Target	Alias	Description	ECC score	Gene Family Method
Bradi1g29010	No alias	SU(VAR)3-9 homolog 2	0.02	Orthogroups_2024-Update
Bradi1g53840	No alias	SU(VAR)3-9 homolog 1	0.05	Orthogroups_2024-Update
Bradi4g28460	No alias	SU(VAR)3-9 homolog 6	0.03	Orthogroups_2024-Update
Bradi4g28792	No alias	SU(VAR)3-9 homolog 6	0.02	Orthogroups_2024-Update
Brara.J02694.1	No alias	methylated DNA binding component *(SUVH1/3) of SUVH-DNAJ...	0.02	Orthogroups_2024-Update
Cre02.g089200	No alias	SU(VAR)3-9 homolog 6	0.03	Orthogroups_2024-Update
GRMZM2G300955	No alias	SU(VAR)3-9 homolog 5	0.03	Orthogroups_2024-Update
Sobic.002G079100.2	No alias	methylated DNA binding component *(SUVH1/3) of SUVH-DNAJ...	0.03	Orthogroups_2024-Update
Solyc09g082050	No alias	Histone-lysine N-methyltransferase, H3 lysine-9 specific...	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	IEA	InterProScan predictions
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005634	nucleus	IEA	InterProScan predictions
BP	GO:0006325	chromatin organization	None	Extended
BP	GO:0006464	cellular protein modification process	None	Extended
BP	GO:0006479	protein methylation	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008168	methyltransferase activity	None	Extended
MF	GO:0008170	N-methyltransferase activity	None	Extended
BP	GO:0008213	protein alkylation	None	Extended
MF	GO:0008270	zinc ion binding	IEA	InterProScan predictions
MF	GO:0008276	protein methyltransferase activity	None	Extended
MF	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016043	cellular component organization	None	Extended
MF	GO:0016278	lysine N-methyltransferase activity	None	Extended
MF	GO:0016279	protein-lysine N-methyltransferase activity	None	Extended
BP	GO:0016569	covalent chromatin modification	None	Extended
BP	GO:0016570	histone modification	None	Extended
BP	GO:0016571	histone methylation	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016741	transferase activity, transferring one-carbon groups	None	Extended
BP	GO:0018022	peptidyl-lysine methylation	None	Extended
MF	GO:0018024	histone-lysine N-methyltransferase activity	IEA	InterProScan predictions
BP	GO:0018193	peptidyl-amino acid modification	None	Extended
BP	GO:0018205	peptidyl-lysine modification	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
BP	GO:0032259	methylation	None	Extended
BP	GO:0034968	histone lysine methylation	IEA	InterProScan predictions
BP	GO:0036211	protein modification process	None	Extended
MF	GO:0042054	histone methyltransferase activity	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0043412	macromolecule modification	None	Extended
BP	GO:0043414	macromolecule methylation	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0044267	cellular protein metabolic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044464	cell part	None	Extended
MF	GO:0046872	metal ion binding	None	Extended
MF	GO:0046914	transition metal ion binding	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0071840	cellular component organization or biogenesis	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
CC	GO:0000159	protein phosphatase type 2A complex	IEP	Predicted GO
CC	GO:0000428	DNA-directed RNA polymerase complex	IEP	Predicted GO
MF	GO:0001882	nucleoside binding	IEP	Predicted GO
MF	GO:0001883	purine nucleoside binding	IEP	Predicted GO
BP	GO:0002097	tRNA wobble base modification	IEP	Predicted GO
BP	GO:0002100	tRNA wobble adenosine to inosine editing	IEP	Predicted GO
MF	GO:0003676	nucleic acid binding	IEP	Predicted GO
MF	GO:0003723	RNA binding	IEP	Predicted GO
MF	GO:0004000	adenosine deaminase activity	IEP	Predicted GO
MF	GO:0004721	phosphoprotein phosphatase activity	IEP	Predicted GO
MF	GO:0005525	GTP binding	IEP	Predicted GO
CC	GO:0005643	nuclear pore	IEP	Predicted GO
CC	GO:0005665	RNA polymerase II, core complex	IEP	Predicted GO
BP	GO:0006357	regulation of transcription by RNA polymerase II	IEP	Predicted GO
BP	GO:0006366	transcription by RNA polymerase II	IEP	Predicted GO
BP	GO:0006382	adenosine to inosine editing	IEP	Predicted GO
BP	GO:0006400	tRNA modification	IEP	Predicted GO
BP	GO:0006476	protein deacetylation	IEP	Predicted GO
MF	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IEP	Predicted GO
MF	GO:0008251	tRNA-specific adenosine deaminase activity	IEP	Predicted GO
CC	GO:0008287	protein serine/threonine phosphatase complex	IEP	Predicted GO
BP	GO:0009451	RNA modification	IEP	Predicted GO
BP	GO:0016311	dephosphorylation	IEP	Predicted GO
BP	GO:0016553	base conversion or substitution editing	IEP	Predicted GO
BP	GO:0016575	histone deacetylation	IEP	Predicted GO
CC	GO:0016592	mediator complex	IEP	Predicted GO
MF	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEP	Predicted GO
MF	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	IEP	Predicted GO
MF	GO:0019001	guanyl nucleotide binding	IEP	Predicted GO
MF	GO:0019208	phosphatase regulator activity	IEP	Predicted GO
MF	GO:0019239	deaminase activity	IEP	Predicted GO
MF	GO:0019888	protein phosphatase regulator activity	IEP	Predicted GO
CC	GO:0030880	RNA polymerase complex	IEP	Predicted GO
CC	GO:0031011	Ino80 complex	IEP	Predicted GO
MF	GO:0032549	ribonucleoside binding	IEP	Predicted GO
MF	GO:0032550	purine ribonucleoside binding	IEP	Predicted GO
MF	GO:0032561	guanyl ribonucleotide binding	IEP	Predicted GO
CC	GO:0032991	protein-containing complex	IEP	Predicted GO
CC	GO:0033202	DNA helicase complex	IEP	Predicted GO
BP	GO:0035601	protein deacylation	IEP	Predicted GO
CC	GO:0044422	organelle part	IEP	Predicted GO
CC	GO:0044428	nuclear part	IEP	Predicted GO
CC	GO:0044446	intracellular organelle part	IEP	Predicted GO
CC	GO:0044451	nucleoplasm part	IEP	Predicted GO
CC	GO:0044454	nuclear chromosome part	IEP	Predicted GO
CC	GO:0055029	nuclear DNA-directed RNA polymerase complex	IEP	Predicted GO
CC	GO:0061695	transferase complex, transferring phosphorus-containing groups	IEP	Predicted GO
CC	GO:0070603	SWI/SNF superfamily-type complex	IEP	Predicted GO
CC	GO:0097346	INO80-type complex	IEP	Predicted GO
BP	GO:0098732	macromolecule deacylation	IEP	Predicted GO
CC	GO:1902494	catalytic complex	IEP	Predicted GO
CC	GO:1903293	phosphatase complex	IEP	Predicted GO
CC	GO:1904949	ATPase complex	IEP	Predicted GO
CC	GO:1990234	transferase complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR003105	SRA_YDG	373	533
IPR007728	Pre-SET_dom	563	664
IPR001214	SET_dom	683	821

External Links

No external refs found!

PSME_00021046-RA

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation