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  5. PSME_00022177-RA

PSME_00022177-RA


Description : (o24146|4cl2_tobac : 717.0) 4-coumarate--CoA ligase 2 (EC 6.2.1.12) (4CL 2) (4-coumaroyl-CoA synthase 2) - Nicotiana tabacum (Common tobacco) & (at1g65060 : 693.0) encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. mRNA levels are not induced in response to wounding or to fungal infection by P. parasitica. mRNA is expressed in flowers, to a lesser degree in mature leaves and siliques and marginally in seedling roots and bolting stems of mature plants. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, ferulic acid, cinnamic acid and 5-OH-ferulic acid. At4CL3 was unable to use sinapic acid as substrate.; 4-coumarate:CoA ligase 3 (4CL3); CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: 4-coumarate:CoA ligase 2 (TAIR:AT3G21240.1); Has 78268 Blast hits to 71395 proteins in 3651 species: Archae - 1111; Bacteria - 51774; Metazoa - 3299; Fungi - 4373; Plants - 2538; Viruses - 1; Other Eukaryotes - 15172 (source: NCBI BLink). & (reliability: 1386.0) & (original description: no original description)


Gene families : OG_42_0000133 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000133_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Pseudotsuga release: PSME_00022177-RA
Cluster HCCA clusters: Cluster_1

Target Alias Description ECC score Gene Family Method Actions
171251 No alias 4-coumarate:CoA ligase 2 0.02 Orthogroups_2024-Update
A4A49_10638 No alias 4-coumarate--coa ligase 2 0.02 Orthogroups_2024-Update
A4A49_41306 No alias 4-coumarate--coa ligase 2 0.03 Orthogroups_2024-Update
At1g65060 No alias 4-coumarate--CoA ligase 3... 0.04 Orthogroups_2024-Update
Bradi3g52350 No alias 4-coumarate:CoA ligase 3 0.02 Orthogroups_2024-Update
Bradi5g04760 No alias acyl-CoA synthetase 5 0.03 Orthogroups_2024-Update
Brara.G02592.1 No alias p-coumarate 0.04 Orthogroups_2024-Update
HORVU0Hr1G018190.6 No alias Unknown function 0.02 Orthogroups_2024-Update
HORVU6Hr1G030390.2 No alias p-coumarate 0.06 Orthogroups_2024-Update
LOC_Os03g04000 No alias AMP-binding domain containing protein, expressed 0.03 Orthogroups_2024-Update
LOC_Os03g05780 No alias 4-coumarate--CoA ligase-like 7, putative, expressed 0.03 Orthogroups_2024-Update
MA_109119g0010 No alias (p31687|4cl2_soybn : 667.0) 4-coumarate--CoA ligase 2... 0.12 Orthogroups_2024-Update
Potri.018G094200 No alias 4-coumarate:CoA ligase 2 0.06 Orthogroups_2024-Update
Pp1s12_59V6 No alias amp dependent 0.02 Orthogroups_2024-Update
Pp1s20_346V6 No alias 4-coumarate: ligase 0.04 Orthogroups_2024-Update
Pp1s71_170V6 No alias 4-coumarate: ligase 0.09 Orthogroups_2024-Update
Seita.1G065800.1 No alias p-coumarate 0.03 Orthogroups_2024-Update
Seita.1G283300.1 No alias p-coumarate 0.05 Orthogroups_2024-Update
Seita.4G191500.1 No alias p-coumarate 0.03 Orthogroups_2024-Update
Seita.9G552000.1 No alias OPC-8 0.04 Orthogroups_2024-Update
Sobic.001G516600.1 No alias OPC-8 0.02 Orthogroups_2024-Update
Sobic.004G272700.1 No alias p-coumarate 0.03 Orthogroups_2024-Update
Solyc03g111170 No alias 4-coumarate:CoA ligase-like protein (AHRD V3.3 *** G7J515_MEDTR) 0.03 Orthogroups_2024-Update
Solyc03g117870 No alias 4-coumarate--CoA ligase 0.03 Orthogroups_2024-Update
Sopen06g025930 No alias AMP-binding enzyme 0.03 Orthogroups_2024-Update
Sopen12g031420 No alias AMP-binding enzyme 0.04 Orthogroups_2024-Update

Type GO Term Name Evidence Source
MF GO:0003824 catalytic activity IEA InterProScan predictions
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Type GO Term Name Evidence Source
MF GO:0000287 magnesium ion binding IEP Predicted GO
MF GO:0003684 damaged DNA binding IEP Predicted GO
MF GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity IEP Predicted GO
MF GO:0003855 3-dehydroquinate dehydratase activity IEP Predicted GO
MF GO:0003872 6-phosphofructokinase activity IEP Predicted GO
MF GO:0003989 acetyl-CoA carboxylase activity IEP Predicted GO
MF GO:0004107 chorismate synthase activity IEP Predicted GO
MF GO:0004470 malic enzyme activity IEP Predicted GO
MF GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity IEP Predicted GO
MF GO:0004560 alpha-L-fucosidase activity IEP Predicted GO
MF GO:0004664 prephenate dehydratase activity IEP Predicted GO
MF GO:0004743 pyruvate kinase activity IEP Predicted GO
MF GO:0004764 shikimate 3-dehydrogenase (NADP+) activity IEP Predicted GO
MF GO:0005506 iron ion binding IEP Predicted GO
CC GO:0005856 cytoskeleton IEP Predicted GO
CC GO:0005885 Arp2/3 protein complex IEP Predicted GO
BP GO:0006082 organic acid metabolic process IEP Predicted GO
BP GO:0006090 pyruvate metabolic process IEP Predicted GO
BP GO:0006091 generation of precursor metabolites and energy IEP Predicted GO
BP GO:0006096 glycolytic process IEP Predicted GO
BP GO:0006139 nucleobase-containing compound metabolic process IEP Predicted GO
BP GO:0006163 purine nucleotide metabolic process IEP Predicted GO
BP GO:0006164 purine nucleotide biosynthetic process IEP Predicted GO
BP GO:0006165 nucleoside diphosphate phosphorylation IEP Predicted GO
BP GO:0006289 nucleotide-excision repair IEP Predicted GO
BP GO:0006520 cellular amino acid metabolic process IEP Predicted GO
BP GO:0006558 L-phenylalanine metabolic process IEP Predicted GO
BP GO:0006725 cellular aromatic compound metabolic process IEP Predicted GO
BP GO:0006732 coenzyme metabolic process IEP Predicted GO
BP GO:0006733 oxidoreduction coenzyme metabolic process IEP Predicted GO
BP GO:0006753 nucleoside phosphate metabolic process IEP Predicted GO
BP GO:0006754 ATP biosynthetic process IEP Predicted GO
BP GO:0006757 ATP generation from ADP IEP Predicted GO
BP GO:0007015 actin filament organization IEP Predicted GO
BP GO:0008064 regulation of actin polymerization or depolymerization IEP Predicted GO
BP GO:0008152 metabolic process IEP Predicted GO
MF GO:0008198 ferrous iron binding IEP Predicted GO
MF GO:0008443 phosphofructokinase activity IEP Predicted GO
BP GO:0008652 cellular amino acid biosynthetic process IEP Predicted GO
BP GO:0009056 catabolic process IEP Predicted GO
BP GO:0009058 biosynthetic process IEP Predicted GO
BP GO:0009072 aromatic amino acid family metabolic process IEP Predicted GO
BP GO:0009073 aromatic amino acid family biosynthetic process IEP Predicted GO
BP GO:0009094 L-phenylalanine biosynthetic process IEP Predicted GO
BP GO:0009095 aromatic amino acid family biosynthetic process, prephenate pathway IEP Predicted GO
BP GO:0009108 coenzyme biosynthetic process IEP Predicted GO
BP GO:0009117 nucleotide metabolic process IEP Predicted GO
BP GO:0009123 nucleoside monophosphate metabolic process IEP Predicted GO
BP GO:0009124 nucleoside monophosphate biosynthetic process IEP Predicted GO
BP GO:0009126 purine nucleoside monophosphate metabolic process IEP Predicted GO
BP GO:0009127 purine nucleoside monophosphate biosynthetic process IEP Predicted GO
BP GO:0009132 nucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009135 purine nucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009141 nucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009142 nucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009144 purine nucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009145 purine nucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009150 purine ribonucleotide metabolic process IEP Predicted GO
BP GO:0009152 purine ribonucleotide biosynthetic process IEP Predicted GO
BP GO:0009156 ribonucleoside monophosphate biosynthetic process IEP Predicted GO
BP GO:0009161 ribonucleoside monophosphate metabolic process IEP Predicted GO
BP GO:0009165 nucleotide biosynthetic process IEP Predicted GO
BP GO:0009166 nucleotide catabolic process IEP Predicted GO
BP GO:0009167 purine ribonucleoside monophosphate metabolic process IEP Predicted GO
BP GO:0009168 purine ribonucleoside monophosphate biosynthetic process IEP Predicted GO
BP GO:0009179 purine ribonucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009185 ribonucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009199 ribonucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009201 ribonucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009205 purine ribonucleoside triphosphate metabolic process IEP Predicted GO
BP GO:0009206 purine ribonucleoside triphosphate biosynthetic process IEP Predicted GO
BP GO:0009259 ribonucleotide metabolic process IEP Predicted GO
BP GO:0009260 ribonucleotide biosynthetic process IEP Predicted GO
BP GO:0010498 proteasomal protein catabolic process IEP Predicted GO
BP GO:0010638 positive regulation of organelle organization IEP Predicted GO
MF GO:0015238 drug transmembrane transporter activity IEP Predicted GO
CC GO:0015629 actin cytoskeleton IEP Predicted GO
MF GO:0015928 fucosidase activity IEP Predicted GO
BP GO:0016052 carbohydrate catabolic process IEP Predicted GO
BP GO:0016053 organic acid biosynthetic process IEP Predicted GO
MF GO:0016421 CoA carboxylase activity IEP Predicted GO
MF GO:0016491 oxidoreductase activity IEP Predicted GO
MF GO:0016614 oxidoreductase activity, acting on CH-OH group of donors IEP Predicted GO
MF GO:0016615 malate dehydrogenase activity IEP Predicted GO
MF GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEP Predicted GO
MF GO:0016746 transferase activity, transferring acyl groups IEP Predicted GO
MF GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups IEP Predicted GO
MF GO:0016829 lyase activity IEP Predicted GO
MF GO:0016835 carbon-oxygen lyase activity IEP Predicted GO
MF GO:0016836 hydro-lyase activity IEP Predicted GO
MF GO:0016872 intramolecular lyase activity IEP Predicted GO
MF GO:0016885 ligase activity, forming carbon-carbon bonds IEP Predicted GO
BP GO:0017144 drug metabolic process IEP Predicted GO
BP GO:0018130 heterocycle biosynthetic process IEP Predicted GO
MF GO:0019200 carbohydrate kinase activity IEP Predicted GO
BP GO:0019359 nicotinamide nucleotide biosynthetic process IEP Predicted GO
BP GO:0019362 pyridine nucleotide metabolic process IEP Predicted GO
BP GO:0019363 pyridine nucleotide biosynthetic process IEP Predicted GO
BP GO:0019438 aromatic compound biosynthetic process IEP Predicted GO
BP GO:0019439 aromatic compound catabolic process IEP Predicted GO
BP GO:0019637 organophosphate metabolic process IEP Predicted GO
BP GO:0019693 ribose phosphate metabolic process IEP Predicted GO
BP GO:0019752 carboxylic acid metabolic process IEP Predicted GO
MF GO:0019842 vitamin binding IEP Predicted GO
BP GO:0030163 protein catabolic process IEP Predicted GO
MF GO:0030170 pyridoxal phosphate binding IEP Predicted GO
BP GO:0030832 regulation of actin filament length IEP Predicted GO
BP GO:0030833 regulation of actin filament polymerization IEP Predicted GO
BP GO:0030838 positive regulation of actin filament polymerization IEP Predicted GO
MF GO:0030955 potassium ion binding IEP Predicted GO
BP GO:0031334 positive regulation of protein complex assembly IEP Predicted GO
MF GO:0031420 alkali metal ion binding IEP Predicted GO
BP GO:0032271 regulation of protein polymerization IEP Predicted GO
BP GO:0032273 positive regulation of protein polymerization IEP Predicted GO
BP GO:0032535 regulation of cellular component size IEP Predicted GO
BP GO:0032787 monocarboxylic acid metabolic process IEP Predicted GO
BP GO:0032956 regulation of actin cytoskeleton organization IEP Predicted GO
BP GO:0032970 regulation of actin filament-based process IEP Predicted GO
BP GO:0033043 regulation of organelle organization IEP Predicted GO
BP GO:0034314 Arp2/3 complex-mediated actin nucleation IEP Predicted GO
BP GO:0034404 nucleobase-containing small molecule biosynthetic process IEP Predicted GO
BP GO:0034654 nucleobase-containing compound biosynthetic process IEP Predicted GO
BP GO:0034655 nucleobase-containing compound catabolic process IEP Predicted GO
BP GO:0042866 pyruvate biosynthetic process IEP Predicted GO
BP GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEP Predicted GO
BP GO:0043254 regulation of protein complex assembly IEP Predicted GO
BP GO:0043436 oxoacid metabolic process IEP Predicted GO
BP GO:0044087 regulation of cellular component biogenesis IEP Predicted GO
BP GO:0044089 positive regulation of cellular component biogenesis IEP Predicted GO
BP GO:0044248 cellular catabolic process IEP Predicted GO
BP GO:0044249 cellular biosynthetic process IEP Predicted GO
BP GO:0044270 cellular nitrogen compound catabolic process IEP Predicted GO
BP GO:0044271 cellular nitrogen compound biosynthetic process IEP Predicted GO
BP GO:0044281 small molecule metabolic process IEP Predicted GO
BP GO:0044283 small molecule biosynthetic process IEP Predicted GO
BP GO:0045010 actin nucleation IEP Predicted GO
BP GO:0046031 ADP metabolic process IEP Predicted GO
BP GO:0046034 ATP metabolic process IEP Predicted GO
BP GO:0046390 ribose phosphate biosynthetic process IEP Predicted GO
BP GO:0046394 carboxylic acid biosynthetic process IEP Predicted GO
BP GO:0046434 organophosphate catabolic process IEP Predicted GO
BP GO:0046483 heterocycle metabolic process IEP Predicted GO
BP GO:0046496 nicotinamide nucleotide metabolic process IEP Predicted GO
BP GO:0046700 heterocycle catabolic process IEP Predicted GO
MF GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer IEP Predicted GO
BP GO:0046939 nucleotide phosphorylation IEP Predicted GO
MF GO:0048037 cofactor binding IEP Predicted GO
BP GO:0048518 positive regulation of biological process IEP Predicted GO
BP GO:0048522 positive regulation of cellular process IEP Predicted GO
MF GO:0050662 coenzyme binding IEP Predicted GO
BP GO:0051128 regulation of cellular component organization IEP Predicted GO
BP GO:0051130 positive regulation of cellular component organization IEP Predicted GO
BP GO:0051186 cofactor metabolic process IEP Predicted GO
BP GO:0051188 cofactor biosynthetic process IEP Predicted GO
BP GO:0051493 regulation of cytoskeleton organization IEP Predicted GO
BP GO:0051495 positive regulation of cytoskeleton organization IEP Predicted GO
BP GO:0055086 nucleobase-containing small molecule metabolic process IEP Predicted GO
BP GO:0055114 oxidation-reduction process IEP Predicted GO
MF GO:0070279 vitamin B6 binding IEP Predicted GO
BP GO:0072330 monocarboxylic acid biosynthetic process IEP Predicted GO
BP GO:0072521 purine-containing compound metabolic process IEP Predicted GO
BP GO:0072522 purine-containing compound biosynthetic process IEP Predicted GO
BP GO:0072524 pyridine-containing compound metabolic process IEP Predicted GO
BP GO:0072525 pyridine-containing compound biosynthetic process IEP Predicted GO
BP GO:0090066 regulation of anatomical structure size IEP Predicted GO
BP GO:0090407 organophosphate biosynthetic process IEP Predicted GO
BP GO:0097435 supramolecular fiber organization IEP Predicted GO
BP GO:0110053 regulation of actin filament organization IEP Predicted GO
BP GO:1901135 carbohydrate derivative metabolic process IEP Predicted GO
BP GO:1901137 carbohydrate derivative biosynthetic process IEP Predicted GO
BP GO:1901292 nucleoside phosphate catabolic process IEP Predicted GO
BP GO:1901293 nucleoside phosphate biosynthetic process IEP Predicted GO
BP GO:1901360 organic cyclic compound metabolic process IEP Predicted GO
BP GO:1901361 organic cyclic compound catabolic process IEP Predicted GO
BP GO:1901362 organic cyclic compound biosynthetic process IEP Predicted GO
BP GO:1901566 organonitrogen compound biosynthetic process IEP Predicted GO
BP GO:1901575 organic substance catabolic process IEP Predicted GO
BP GO:1901576 organic substance biosynthetic process IEP Predicted GO
BP GO:1901605 alpha-amino acid metabolic process IEP Predicted GO
BP GO:1901607 alpha-amino acid biosynthetic process IEP Predicted GO
BP GO:1902221 erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process IEP Predicted GO
BP GO:1902223 erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process IEP Predicted GO
BP GO:1902903 regulation of supramolecular fiber organization IEP Predicted GO
BP GO:1902905 positive regulation of supramolecular fiber organization IEP Predicted GO
InterPro domains Description Start Stop
IPR000873 AMP-dep_Synth/Lig 61 469
IPR025110 AMP-bd_C 478 553
No external refs found!