evm.model.tig00000145.4

Description : (at3g19050 : 249.0) PHRAGMOPLAST ORIENTING KINESIN 2 is one of the two Arabidopsis homologs isolated in yeast two-hybrid screen for interaction partners of maize gene TANGLED1 (TAN1). Based on sequence homology in their motor domains, POK1 and POK2 belong to the kinesin-12 class which also includes the well-characterized group of phragmoplast-associated kinesins AtPAKRPs. Both kinesins are composed of an N-terminal motor domain throughout the entire C terminus and putative cargo binding tail domains. The expression domains for POK2 constructs were broader than those for POK1; both are expressed in tissues enriched for dividing cells. The phenotype of pok1/pok2 double mutants strongly resembles that of maize tan1 mutants, characterized by misoriented mitotic cytoskeletal arrays and misplaced cell walls.; phragmoplast orienting kinesin 2 (POK2); FUNCTIONS IN: microtubule motor activity, ATP binding; INVOLVED IN: cytokinesis; EXPRESSED IN: root vascular system, primary root tip, lateral root primordium; CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: phragmoplast orienting kinesin 1 (TAIR:AT3G17360.1); Has 204267 Blast hits to 80386 proteins in 3219 species: Archae - 3327; Bacteria - 35963; Metazoa - 90351; Fungi - 17822; Plants - 12667; Viruses - 746; Other Eukaryotes - 43391 (source: NCBI BLink). & (p46869|fla10_chlre : 228.0) Kinesin-like protein FLA10 (Protein KHP1) - Chlamydomonas reinhardtii & (reliability: 498.0) & (original description: no original description)

Gene families : OG_42_0000151 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000151_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Cyanophora release: evm.model.tig00000145.4
Cluster	HCCA clusters: Cluster_176

Target	Alias	Description	ECC score	Gene Family Method
Cre12.g546100	No alias	P-loop containing nucleoside triphosphate hydrolases...	0.01	Orthogroups_2024-Update
Cre17.g741350	No alias	P-loop containing nucleoside triphosphate hydrolases...	0.01	Orthogroups_2024-Update
Cre19.g750197	No alias	P-loop containing nucleoside triphosphate hydrolases...	0.02	Orthogroups_2024-Update
GRMZM2G115489	No alias	P-loop containing nucleoside triphosphate hydrolases...	0.01	Orthogroups_2024-Update
Glyma.17G208400	No alias	P-loop containing nucleoside triphosphate hydrolases...	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003774	motor activity	None	Extended
MF	GO:0003777	microtubule motor activity	IEA	InterProScan predictions
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	None	Extended
MF	GO:0005524	ATP binding	IEA	InterProScan predictions
BP	GO:0006928	movement of cell or subcellular component	None	Extended
BP	GO:0007017	microtubule-based process	None	Extended
BP	GO:0007018	microtubule-based movement	IEA	InterProScan predictions
MF	GO:0008017	microtubule binding	IEA	InterProScan predictions
MF	GO:0008092	cytoskeletal protein binding	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0015631	tubulin binding	None	Extended
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000049	tRNA binding	IEP	Predicted GO
BP	GO:0002097	tRNA wobble base modification	IEP	Predicted GO
BP	GO:0002098	tRNA wobble uridine modification	IEP	Predicted GO
MF	GO:0003916	DNA topoisomerase activity	IEP	Predicted GO
MF	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	IEP	Predicted GO
MF	GO:0003951	NAD+ kinase activity	IEP	Predicted GO
MF	GO:0004345	glucose-6-phosphate dehydrogenase activity	IEP	Predicted GO
MF	GO:0004435	phosphatidylinositol phospholipase C activity	IEP	Predicted GO
MF	GO:0004620	phospholipase activity	IEP	Predicted GO
MF	GO:0004629	phospholipase C activity	IEP	Predicted GO
MF	GO:0004649	poly(ADP-ribose) glycohydrolase activity	IEP	Predicted GO
BP	GO:0005996	monosaccharide metabolic process	IEP	Predicted GO
BP	GO:0006006	glucose metabolic process	IEP	Predicted GO
BP	GO:0006265	DNA topological change	IEP	Predicted GO
BP	GO:0006739	NADP metabolic process	IEP	Predicted GO
BP	GO:0006741	NADP biosynthetic process	IEP	Predicted GO
MF	GO:0008094	DNA-dependent ATPase activity	IEP	Predicted GO
MF	GO:0008658	penicillin binding	IEP	Predicted GO
MF	GO:0008716	D-alanine-D-alanine ligase activity	IEP	Predicted GO
BP	GO:0010970	transport along microtubule	IEP	Predicted GO
MF	GO:0016298	lipase activity	IEP	Predicted GO
BP	GO:0016485	protein processing	IEP	Predicted GO
BP	GO:0019318	hexose metabolic process	IEP	Predicted GO
BP	GO:0030705	cytoskeleton-dependent intracellular transport	IEP	Predicted GO
MF	GO:0031406	carboxylic acid binding	IEP	Predicted GO
BP	GO:0031503	protein-containing complex localization	IEP	Predicted GO
MF	GO:0033293	monocarboxylic acid binding	IEP	Predicted GO
BP	GO:0034227	tRNA thio-modification	IEP	Predicted GO
BP	GO:0042073	intraciliary transport	IEP	Predicted GO
MF	GO:0043177	organic acid binding	IEP	Predicted GO
BP	GO:0051604	protein maturation	IEP	Predicted GO
MF	GO:0061505	DNA topoisomerase II activity	IEP	Predicted GO
BP	GO:0098840	protein transport along microtubule	IEP	Predicted GO
BP	GO:0099111	microtubule-based transport	IEP	Predicted GO
BP	GO:0099118	microtubule-based protein transport	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR001752	Kinesin_motor_dom	27	369

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evm.model.tig00000145.4

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation