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  5. evm.model.tig00001366.9

evm.model.tig00001366.9


Description : (at1g22940 : 111.0) Encodes a bifunctional enzyme required for thiamine (vitamin B1) biosynthesis. TH1 can phosphorylate HMP-P to produce HMP-PP, the pyrimidine heterocyclic subunit of thiamine. TH1 also catalyzes the condensation of HMP-PP and HET to form thiamine monophosphate (TMP). TH1 also appears capable of phosphorylating HMP based on E.coli mutant complementation assays. th1 mutants are thiamine auxotrophs that die as seedlings on unsupplemented media.; THIAMINE REQUIRING 1 (TH1); FUNCTIONS IN: phosphomethylpyrimidine kinase activity, thiamin-phosphate diphosphorylase activity, hydroxymethylpyrimidine kinase activity; INVOLVED IN: thiamin biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiamine monophosphate synthase (InterPro:IPR003733), Phosphomethylpyrimidine kinase type-2 (InterPro:IPR004399), Aldolase-type TIM barrel (InterPro:IPR013785), Phosphomethylpyrimidine kinase type-1 (InterPro:IPR013749); Has 15989 Blast hits to 15891 proteins in 2548 species: Archae - 338; Bacteria - 12149; Metazoa - 165; Fungi - 331; Plants - 107; Viruses - 0; Other Eukaryotes - 2899 (source: NCBI BLink). & (reliability: 222.0) & (original description: no original description)


Gene families : OG_42_0005927 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0005927_tree

Sequence : coding (download), protein (download)


Attention: This gene has low abundance.


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Cyanophora release: evm.model.tig00001366.9
Cluster HCCA clusters: Cluster_59


Type GO Term Name Evidence Source

No GO annotation available for this sequence
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Type GO Term Name Evidence Source
MF GO:0000155 phosphorelay sensor kinase activity IEP Predicted GO
BP GO:0000160 phosphorelay signal transduction system IEP Predicted GO
MF GO:0001871 pattern binding IEP Predicted GO
MF GO:0004133 glycogen debranching enzyme activity IEP Predicted GO
MF GO:0004134 4-alpha-glucanotransferase activity IEP Predicted GO
MF GO:0004363 glutathione synthase activity IEP Predicted GO
MF GO:0004518 nuclease activity IEP Predicted GO
MF GO:0004527 exonuclease activity IEP Predicted GO
MF GO:0004673 protein histidine kinase activity IEP Predicted GO
BP GO:0006497 protein lipidation IEP Predicted GO
BP GO:0006505 GPI anchor metabolic process IEP Predicted GO
BP GO:0006506 GPI anchor biosynthetic process IEP Predicted GO
BP GO:0006575 cellular modified amino acid metabolic process IEP Predicted GO
BP GO:0006643 membrane lipid metabolic process IEP Predicted GO
BP GO:0006650 glycerophospholipid metabolic process IEP Predicted GO
BP GO:0006661 phosphatidylinositol biosynthetic process IEP Predicted GO
BP GO:0006664 glycolipid metabolic process IEP Predicted GO
BP GO:0006749 glutathione metabolic process IEP Predicted GO
BP GO:0006750 glutathione biosynthetic process IEP Predicted GO
MF GO:0008194 UDP-glycosyltransferase activity IEP Predicted GO
MF GO:0008375 acetylglucosaminyltransferase activity IEP Predicted GO
BP GO:0009247 glycolipid biosynthetic process IEP Predicted GO
MF GO:0016740 transferase activity IEP Predicted GO
MF GO:0016757 transferase activity, transferring glycosyl groups IEP Predicted GO
MF GO:0016758 transferase activity, transferring hexosyl groups IEP Predicted GO
MF GO:0016775 phosphotransferase activity, nitrogenous group as acceptor IEP Predicted GO
MF GO:0016881 acid-amino acid ligase activity IEP Predicted GO
MF GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity IEP Predicted GO
BP GO:0019184 nonribosomal peptide biosynthetic process IEP Predicted GO
MF GO:0030246 carbohydrate binding IEP Predicted GO
MF GO:0030247 polysaccharide binding IEP Predicted GO
MF GO:0030976 thiamine pyrophosphate binding IEP Predicted GO
BP GO:0042398 cellular modified amino acid biosynthetic process IEP Predicted GO
BP GO:0044272 sulfur compound biosynthetic process IEP Predicted GO
BP GO:0045017 glycerolipid biosynthetic process IEP Predicted GO
BP GO:0046467 membrane lipid biosynthetic process IEP Predicted GO
BP GO:0046474 glycerophospholipid biosynthetic process IEP Predicted GO
BP GO:0046488 phosphatidylinositol metabolic process IEP Predicted GO
MF GO:1901681 sulfur compound binding IEP Predicted GO
BP GO:1903509 liposaccharide metabolic process IEP Predicted GO
MF GO:2001070 starch binding IEP Predicted GO
InterPro domains Description Start Stop
IPR013749 PM/HMP-P_kinase-1 2 50
IPR013749 PM/HMP-P_kinase-1 110 286
No external refs found!