Description : (at1g22940 : 111.0) Encodes a bifunctional enzyme required for thiamine (vitamin B1) biosynthesis. TH1 can phosphorylate HMP-P to produce HMP-PP, the pyrimidine heterocyclic subunit of thiamine. TH1 also catalyzes the condensation of HMP-PP and HET to form thiamine monophosphate (TMP). TH1 also appears capable of phosphorylating HMP based on E.coli mutant complementation assays. th1 mutants are thiamine auxotrophs that die as seedlings on unsupplemented media.; THIAMINE REQUIRING 1 (TH1); FUNCTIONS IN: phosphomethylpyrimidine kinase activity, thiamin-phosphate diphosphorylase activity, hydroxymethylpyrimidine kinase activity; INVOLVED IN: thiamin biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiamine monophosphate synthase (InterPro:IPR003733), Phosphomethylpyrimidine kinase type-2 (InterPro:IPR004399), Aldolase-type TIM barrel (InterPro:IPR013785), Phosphomethylpyrimidine kinase type-1 (InterPro:IPR013749); Has 15989 Blast hits to 15891 proteins in 2548 species: Archae - 338; Bacteria - 12149; Metazoa - 165; Fungi - 331; Plants - 107; Viruses - 0; Other Eukaryotes - 2899 (source: NCBI BLink). & (reliability: 222.0) & (original description: no original description)
Gene families : OG_42_0005927 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0005927_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | Cyanophora release: evm.model.tig00001366.9 | |
Cluster | HCCA clusters: Cluster_59 |
Type | GO Term | Name | Evidence | Source |
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No GO annotation available for this sequence |
Type | GO Term | Name | Evidence | Source |
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MF | GO:0000155 | phosphorelay sensor kinase activity | IEP | Predicted GO |
BP | GO:0000160 | phosphorelay signal transduction system | IEP | Predicted GO |
MF | GO:0001871 | pattern binding | IEP | Predicted GO |
MF | GO:0004133 | glycogen debranching enzyme activity | IEP | Predicted GO |
MF | GO:0004134 | 4-alpha-glucanotransferase activity | IEP | Predicted GO |
MF | GO:0004363 | glutathione synthase activity | IEP | Predicted GO |
MF | GO:0004518 | nuclease activity | IEP | Predicted GO |
MF | GO:0004527 | exonuclease activity | IEP | Predicted GO |
MF | GO:0004673 | protein histidine kinase activity | IEP | Predicted GO |
BP | GO:0006497 | protein lipidation | IEP | Predicted GO |
BP | GO:0006505 | GPI anchor metabolic process | IEP | Predicted GO |
BP | GO:0006506 | GPI anchor biosynthetic process | IEP | Predicted GO |
BP | GO:0006575 | cellular modified amino acid metabolic process | IEP | Predicted GO |
BP | GO:0006643 | membrane lipid metabolic process | IEP | Predicted GO |
BP | GO:0006650 | glycerophospholipid metabolic process | IEP | Predicted GO |
BP | GO:0006661 | phosphatidylinositol biosynthetic process | IEP | Predicted GO |
BP | GO:0006664 | glycolipid metabolic process | IEP | Predicted GO |
BP | GO:0006749 | glutathione metabolic process | IEP | Predicted GO |
BP | GO:0006750 | glutathione biosynthetic process | IEP | Predicted GO |
MF | GO:0008194 | UDP-glycosyltransferase activity | IEP | Predicted GO |
MF | GO:0008375 | acetylglucosaminyltransferase activity | IEP | Predicted GO |
BP | GO:0009247 | glycolipid biosynthetic process | IEP | Predicted GO |
MF | GO:0016740 | transferase activity | IEP | Predicted GO |
MF | GO:0016757 | transferase activity, transferring glycosyl groups | IEP | Predicted GO |
MF | GO:0016758 | transferase activity, transferring hexosyl groups | IEP | Predicted GO |
MF | GO:0016775 | phosphotransferase activity, nitrogenous group as acceptor | IEP | Predicted GO |
MF | GO:0016881 | acid-amino acid ligase activity | IEP | Predicted GO |
MF | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity | IEP | Predicted GO |
BP | GO:0019184 | nonribosomal peptide biosynthetic process | IEP | Predicted GO |
MF | GO:0030246 | carbohydrate binding | IEP | Predicted GO |
MF | GO:0030247 | polysaccharide binding | IEP | Predicted GO |
MF | GO:0030976 | thiamine pyrophosphate binding | IEP | Predicted GO |
BP | GO:0042398 | cellular modified amino acid biosynthetic process | IEP | Predicted GO |
BP | GO:0044272 | sulfur compound biosynthetic process | IEP | Predicted GO |
BP | GO:0045017 | glycerolipid biosynthetic process | IEP | Predicted GO |
BP | GO:0046467 | membrane lipid biosynthetic process | IEP | Predicted GO |
BP | GO:0046474 | glycerophospholipid biosynthetic process | IEP | Predicted GO |
BP | GO:0046488 | phosphatidylinositol metabolic process | IEP | Predicted GO |
MF | GO:1901681 | sulfur compound binding | IEP | Predicted GO |
BP | GO:1903509 | liposaccharide metabolic process | IEP | Predicted GO |
MF | GO:2001070 | starch binding | IEP | Predicted GO |
No external refs found! |