Kfl00082_0190 (kfl00082_0190_v1.1)

Aliases : kfl00082_0190_v1.1

Description : (at3g04740 : 266.0) encodes a protein with similarities to subunits of the Mediator complex, required for RNA polymerase II recruitment at target promoters in response to specific activators. Lines carrying loss of function mutations in the gene have reduced cell numbers in aerial organs. On the other hand, lines overexpressing the gene have increased number of small cells in clusters, suggesting cell division is more unsynchronized in the overexpressors.; STRUWWELPETER (SWP); FUNCTIONS IN: RNA polymerase II transcription mediator activity; INVOLVED IN: positive regulation of transcription, positive regulation of cell proliferation; LOCATED IN: mediator complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Mediator complex, subunit Med14 (InterPro:IPR013947); Has 940 Blast hits to 375 proteins in 163 species: Archae - 0; Bacteria - 61; Metazoa - 117; Fungi - 104; Plants - 74; Viruses - 0; Other Eukaryotes - 584 (source: NCBI BLink). & (reliability: 532.0) & (original description: no original description)

Gene families : OG_42_0004031 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0004031_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Klebsormidium release: Kfl00082_0190
Cluster	HCCA clusters: Cluster_37

Target	Alias	Description	ECC score	Gene Family Method
90823	No alias	RNA polymerase II transcription mediators	0.08	Orthogroups_2024-Update
At3g04740	No alias	Mediator of RNA polymerase II transcription subunit 14...	0.02	Orthogroups_2024-Update
Bradi4g27157	No alias	RNA polymerase II transcription mediators	0.03	Orthogroups_2024-Update
Cre03.g190550	No alias	RNA polymerase II transcription mediators	0.04	Orthogroups_2024-Update
HORVU5Hr1G053430.1	No alias	component *(MED14) of tail module of MEDIATOR...	0.02	Orthogroups_2024-Update
Mp8g13300.1	No alias	component MED14 of tail module of MEDIATOR transcription...	0.02	Orthogroups_2024-Update
Potri.005G053700	No alias	RNA polymerase II transcription mediators	0.03	Orthogroups_2024-Update
Seita.2G162700.1	No alias	component *(MED14) of tail module of MEDIATOR...	0.02	Orthogroups_2024-Update
Seita.6G114600.1	No alias	component *(MED14) of tail module of MEDIATOR...	0.05	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003712	transcription coregulator activity	IEA	InterProScan predictions
CC	GO:0005575	cellular_component	None	Extended
BP	GO:0006355	regulation of transcription, DNA-templated	None	Extended
BP	GO:0006357	regulation of transcription by RNA polymerase II	IEA	InterProScan predictions
BP	GO:0008150	biological_process	None	Extended
BP	GO:0009889	regulation of biosynthetic process	None	Extended
BP	GO:0010468	regulation of gene expression	None	Extended
BP	GO:0010556	regulation of macromolecule biosynthetic process	None	Extended
CC	GO:0016592	mediator complex	IEA	InterProScan predictions
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	None	Extended
BP	GO:0019222	regulation of metabolic process	None	Extended
BP	GO:0031323	regulation of cellular metabolic process	None	Extended
BP	GO:0031326	regulation of cellular biosynthetic process	None	Extended
CC	GO:0032991	protein-containing complex	None	Extended
CC	GO:0044422	organelle part	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044428	nuclear part	None	Extended
CC	GO:0044446	intracellular organelle part	None	Extended
CC	GO:0044451	nucleoplasm part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0051171	regulation of nitrogen compound metabolic process	None	Extended
BP	GO:0051252	regulation of RNA metabolic process	None	Extended
BP	GO:0060255	regulation of macromolecule metabolic process	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0080090	regulation of primary metabolic process	None	Extended
MF	GO:0140110	transcription regulator activity	None	Extended
BP	GO:1903506	regulation of nucleic acid-templated transcription	None	Extended
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	None	Extended
BP	GO:2001141	regulation of RNA biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEP	Predicted GO
BP	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEP	Predicted GO
BP	GO:0000726	non-recombinational repair	IEP	Predicted GO
BP	GO:0000956	nuclear-transcribed mRNA catabolic process	IEP	Predicted GO
MF	GO:0003774	motor activity	IEP	Predicted GO
MF	GO:0003777	microtubule motor activity	IEP	Predicted GO
MF	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	IEP	Predicted GO
MF	GO:0004402	histone acetyltransferase activity	IEP	Predicted GO
MF	GO:0004672	protein kinase activity	IEP	Predicted GO
MF	GO:0004674	protein serine/threonine kinase activity	IEP	Predicted GO
MF	GO:0004677	DNA-dependent protein kinase activity	IEP	Predicted GO
MF	GO:0005488	binding	IEP	Predicted GO
MF	GO:0005515	protein binding	IEP	Predicted GO
MF	GO:0005524	ATP binding	IEP	Predicted GO
MF	GO:0005543	phospholipid binding	IEP	Predicted GO
CC	GO:0005777	peroxisome	IEP	Predicted GO
CC	GO:0005783	endoplasmic reticulum	IEP	Predicted GO
BP	GO:0006302	double-strand break repair	IEP	Predicted GO
BP	GO:0006303	double-strand break repair via nonhomologous end joining	IEP	Predicted GO
BP	GO:0006351	transcription, DNA-templated	IEP	Predicted GO
BP	GO:0006401	RNA catabolic process	IEP	Predicted GO
BP	GO:0006402	mRNA catabolic process	IEP	Predicted GO
BP	GO:0006464	cellular protein modification process	IEP	Predicted GO
BP	GO:0006473	protein acetylation	IEP	Predicted GO
BP	GO:0006475	internal protein amino acid acetylation	IEP	Predicted GO
BP	GO:0006508	proteolysis	IEP	Predicted GO
BP	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	IEP	Predicted GO
BP	GO:0006928	movement of cell or subcellular component	IEP	Predicted GO
BP	GO:0007017	microtubule-based process	IEP	Predicted GO
BP	GO:0007018	microtubule-based movement	IEP	Predicted GO
BP	GO:0007031	peroxisome organization	IEP	Predicted GO
BP	GO:0007186	G protein-coupled receptor signaling pathway	IEP	Predicted GO
MF	GO:0008080	N-acetyltransferase activity	IEP	Predicted GO
MF	GO:0008144	drug binding	IEP	Predicted GO
MF	GO:0008233	peptidase activity	IEP	Predicted GO
MF	GO:0008234	cysteine-type peptidase activity	IEP	Predicted GO
BP	GO:0009892	negative regulation of metabolic process	IEP	Predicted GO
BP	GO:0009987	cellular process	IEP	Predicted GO
BP	GO:0010605	negative regulation of macromolecule metabolic process	IEP	Predicted GO
BP	GO:0010629	negative regulation of gene expression	IEP	Predicted GO
BP	GO:0016043	cellular component organization	IEP	Predicted GO
BP	GO:0016192	vesicle-mediated transport	IEP	Predicted GO
MF	GO:0016301	kinase activity	IEP	Predicted GO
MF	GO:0016307	phosphatidylinositol phosphate kinase activity	IEP	Predicted GO
MF	GO:0016407	acetyltransferase activity	IEP	Predicted GO
MF	GO:0016410	N-acyltransferase activity	IEP	Predicted GO
BP	GO:0016458	gene silencing	IEP	Predicted GO
BP	GO:0016573	histone acetylation	IEP	Predicted GO
BP	GO:0016579	protein deubiquitination	IEP	Predicted GO
MF	GO:0016740	transferase activity	IEP	Predicted GO
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	IEP	Predicted GO
MF	GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEP	Predicted GO
MF	GO:0016779	nucleotidyltransferase activity	IEP	Predicted GO
MF	GO:0017076	purine nucleotide binding	IEP	Predicted GO
BP	GO:0018393	internal peptidyl-lysine acetylation	IEP	Predicted GO
BP	GO:0018394	peptidyl-lysine acetylation	IEP	Predicted GO
MF	GO:0019783	ubiquitin-like protein-specific protease activity	IEP	Predicted GO
MF	GO:0030554	adenyl nucleotide binding	IEP	Predicted GO
BP	GO:0031047	gene silencing by RNA	IEP	Predicted GO
MF	GO:0031683	G-protein beta/gamma-subunit complex binding	IEP	Predicted GO
MF	GO:0032553	ribonucleotide binding	IEP	Predicted GO
MF	GO:0032555	purine ribonucleotide binding	IEP	Predicted GO
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Predicted GO
MF	GO:0032947	protein-containing complex scaffold activity	IEP	Predicted GO
MF	GO:0034062	5'-3' RNA polymerase activity	IEP	Predicted GO
MF	GO:0034212	peptide N-acetyltransferase activity	IEP	Predicted GO
MF	GO:0035091	phosphatidylinositol binding	IEP	Predicted GO
MF	GO:0035639	purine ribonucleoside triphosphate binding	IEP	Predicted GO
MF	GO:0036094	small molecule binding	IEP	Predicted GO
BP	GO:0036211	protein modification process	IEP	Predicted GO
MF	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	IEP	Predicted GO
CC	GO:0042579	microbody	IEP	Predicted GO
MF	GO:0043167	ion binding	IEP	Predicted GO
MF	GO:0043168	anion binding	IEP	Predicted GO
BP	GO:0043170	macromolecule metabolic process	IEP	Predicted GO
CC	GO:0043227	membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043231	intracellular membrane-bounded organelle	IEP	Predicted GO
BP	GO:0043248	proteasome assembly	IEP	Predicted GO
BP	GO:0043412	macromolecule modification	IEP	Predicted GO
BP	GO:0043543	protein acylation	IEP	Predicted GO
BP	GO:0044260	cellular macromolecule metabolic process	IEP	Predicted GO
MF	GO:0044877	protein-containing complex binding	IEP	Predicted GO
BP	GO:0048193	Golgi vesicle transport	IEP	Predicted GO
BP	GO:0048519	negative regulation of biological process	IEP	Predicted GO
MF	GO:0061733	peptide-lysine-N-acetyltransferase activity	IEP	Predicted GO
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	IEP	Predicted GO
BP	GO:0070646	protein modification by small protein removal	IEP	Predicted GO
BP	GO:0070647	protein modification by small protein conjugation or removal	IEP	Predicted GO
BP	GO:0071840	cellular component organization or biogenesis	IEP	Predicted GO
MF	GO:0097367	carbohydrate derivative binding	IEP	Predicted GO
BP	GO:0097659	nucleic acid-templated transcription	IEP	Predicted GO
MF	GO:0097747	RNA polymerase activity	IEP	Predicted GO
MF	GO:0101005	ubiquitinyl hydrolase activity	IEP	Predicted GO
MF	GO:0140096	catalytic activity, acting on a protein	IEP	Predicted GO
MF	GO:1901265	nucleoside phosphate binding	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR013947	Mediator_Med14	24	211

External Links

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Kfl00082_0190 (kfl00082_0190_v1.1)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation