Kfl00420_0020 (kfl00420_0020_v1.1)

Aliases : kfl00420_0020_v1.1

Description : (q42942|pyr5_tobac : 551.0) Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRTase); Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMPdecase)] (Fragment) - Nicotiana tabacum (Common tobacco) & (at3g54470 : 530.0) encodes the bi-functional orotate phosphoribosyltransferase/orotidine-5'-phosphate decarboxylase catalyzing the fifth and sixth step in the de novo pyrimidine ribonucleotide biosynthesis; uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); FUNCTIONS IN: orotate phosphoribosyltransferase activity, orotidine-5'-phosphate decarboxylase activity; INVOLVED IN: response to cadmium ion, cellular response to phosphate starvation, pyrimidine ribonucleotide biosynthetic process, nucleoside metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Orotidine 5'-phosphate decarboxylase, subfamily 1, core (InterPro:IPR014732), Orotidine 5'-phosphate decarboxylase, active site (InterPro:IPR018089), Ribulose-phosphate binding barrel (InterPro:IPR011060), Phosphoribosyltransferase (InterPro:IPR000836), Orotate phosphoribosyl transferase (InterPro:IPR004467), Orotidine 5'-phosphate decarboxylase, core (InterPro:IPR001754); Has 9174 Blast hits to 9124 proteins in 2964 species: Archae - 386; Bacteria - 5538; Metazoa - 208; Fungi - 955; Plants - 89; Viruses - 3; Other Eukaryotes - 1995 (source: NCBI BLink). & (reliability: 1060.0) & (original description: no original description)

Gene families : OG_42_0004351 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0004351_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Klebsormidium release: Kfl00420_0020
Cluster	HCCA clusters: Cluster_59

Target	Alias	Description	ECC score	Gene Family Method
GRMZM2G109472	No alias	uridine 5\'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS)	0.01	Orthogroups_2024-Update
Mp6g00970.1	No alias	UMP synthase	0.02	Orthogroups_2024-Update
evm.model.tig00000480.72	No alias	(at3g54470 : 467.0) encodes the bi-functional orotate...	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004590	orotidine-5'-phosphate decarboxylase activity	IEA	InterProScan predictions
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006206	pyrimidine nucleobase metabolic process	None	Extended
BP	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	IEA	InterProScan predictions
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009112	nucleobase metabolic process	None	Extended
BP	GO:0009116	nucleoside metabolic process	IEA	InterProScan predictions
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016829	lyase activity	None	Extended
MF	GO:0016830	carbon-carbon lyase activity	None	Extended
MF	GO:0016831	carboxy-lyase activity	None	Extended
BP	GO:0018130	heterocycle biosynthetic process	None	Extended
BP	GO:0019856	pyrimidine nucleobase biosynthetic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044271	cellular nitrogen compound biosynthetic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0046112	nucleobase biosynthetic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0055086	nucleobase-containing small molecule metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0072527	pyrimidine-containing compound metabolic process	None	Extended
BP	GO:0072528	pyrimidine-containing compound biosynthetic process	None	Extended
BP	GO:1901135	carbohydrate derivative metabolic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901362	organic cyclic compound biosynthetic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended
BP	GO:1901657	glycosyl compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000105	histidine biosynthetic process	IEP	Predicted GO
BP	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEP	Predicted GO
MF	GO:0000287	magnesium ion binding	IEP	Predicted GO
BP	GO:0000956	nuclear-transcribed mRNA catabolic process	IEP	Predicted GO
MF	GO:0001871	pattern binding	IEP	Predicted GO
MF	GO:0003723	RNA binding	IEP	Predicted GO
MF	GO:0003746	translation elongation factor activity	IEP	Predicted GO
MF	GO:0003849	3-deoxy-7-phosphoheptulonate synthase activity	IEP	Predicted GO
MF	GO:0003879	ATP phosphoribosyltransferase activity	IEP	Predicted GO
MF	GO:0004017	adenylate kinase activity	IEP	Predicted GO
MF	GO:0004133	glycogen debranching enzyme activity	IEP	Predicted GO
MF	GO:0004134	4-alpha-glucanotransferase activity	IEP	Predicted GO
MF	GO:0004399	histidinol dehydrogenase activity	IEP	Predicted GO
MF	GO:0004427	inorganic diphosphatase activity	IEP	Predicted GO
MF	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	IEP	Predicted GO
MF	GO:0004743	pyruvate kinase activity	IEP	Predicted GO
MF	GO:0004749	ribose phosphate diphosphokinase activity	IEP	Predicted GO
MF	GO:0004779	sulfate adenylyltransferase activity	IEP	Predicted GO
MF	GO:0004781	sulfate adenylyltransferase (ATP) activity	IEP	Predicted GO
MF	GO:0004853	uroporphyrinogen decarboxylase activity	IEP	Predicted GO
MF	GO:0005244	voltage-gated ion channel activity	IEP	Predicted GO
MF	GO:0005247	voltage-gated chloride channel activity	IEP	Predicted GO
MF	GO:0005253	anion channel activity	IEP	Predicted GO
MF	GO:0005254	chloride channel activity	IEP	Predicted GO
BP	GO:0006082	organic acid metabolic process	IEP	Predicted GO
BP	GO:0006163	purine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0006164	purine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0006401	RNA catabolic process	IEP	Predicted GO
BP	GO:0006402	mRNA catabolic process	IEP	Predicted GO
BP	GO:0006414	translational elongation	IEP	Predicted GO
BP	GO:0006520	cellular amino acid metabolic process	IEP	Predicted GO
BP	GO:0006547	histidine metabolic process	IEP	Predicted GO
BP	GO:0006629	lipid metabolic process	IEP	Predicted GO
BP	GO:0006694	steroid biosynthetic process	IEP	Predicted GO
BP	GO:0006753	nucleoside phosphate metabolic process	IEP	Predicted GO
BP	GO:0006754	ATP biosynthetic process	IEP	Predicted GO
BP	GO:0006793	phosphorus metabolic process	IEP	Predicted GO
BP	GO:0006796	phosphate-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006801	superoxide metabolic process	IEP	Predicted GO
BP	GO:0006811	ion transport	IEP	Predicted GO
BP	GO:0006812	cation transport	IEP	Predicted GO
BP	GO:0006821	chloride transport	IEP	Predicted GO
BP	GO:0008202	steroid metabolic process	IEP	Predicted GO
MF	GO:0008308	voltage-gated anion channel activity	IEP	Predicted GO
BP	GO:0008652	cellular amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009072	aromatic amino acid family metabolic process	IEP	Predicted GO
BP	GO:0009073	aromatic amino acid family biosynthetic process	IEP	Predicted GO
BP	GO:0009117	nucleotide metabolic process	IEP	Predicted GO
BP	GO:0009123	nucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009124	nucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009126	purine nucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009127	purine nucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009141	nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009142	nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009144	purine nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009145	purine nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009150	purine ribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009152	purine ribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009156	ribonucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009161	ribonucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009165	nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009167	purine ribonucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009199	ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009201	ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009205	purine ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009206	purine ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009259	ribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009260	ribonucleotide biosynthetic process	IEP	Predicted GO
MF	GO:0009678	hydrogen-translocating pyrophosphatase activity	IEP	Predicted GO
BP	GO:0010468	regulation of gene expression	IEP	Predicted GO
MF	GO:0015108	chloride transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015399	primary active transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	IEP	Predicted GO
BP	GO:0015672	monovalent inorganic cation transport	IEP	Predicted GO
BP	GO:0015985	energy coupled proton transport, down electrochemical gradient	IEP	Predicted GO
BP	GO:0015986	ATP synthesis coupled proton transport	IEP	Predicted GO
BP	GO:0016053	organic acid biosynthetic process	IEP	Predicted GO
BP	GO:0016125	sterol metabolic process	IEP	Predicted GO
MF	GO:0016462	pyrophosphatase activity	IEP	Predicted GO
MF	GO:0016491	oxidoreductase activity	IEP	Predicted GO
MF	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	IEP	Predicted GO
MF	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEP	Predicted GO
MF	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	IEP	Predicted GO
MF	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IEP	Predicted GO
MF	GO:0016740	transferase activity	IEP	Predicted GO
MF	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	IEP	Predicted GO
MF	GO:0016776	phosphotransferase activity, phosphate group as acceptor	IEP	Predicted GO
MF	GO:0016778	diphosphotransferase activity	IEP	Predicted GO
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	IEP	Predicted GO
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEP	Predicted GO
MF	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	IEP	Predicted GO
BP	GO:0017144	drug metabolic process	IEP	Predicted GO
MF	GO:0017150	tRNA dihydrouridine synthase activity	IEP	Predicted GO
MF	GO:0019205	nucleobase-containing compound kinase activity	IEP	Predicted GO
BP	GO:0019438	aromatic compound biosynthetic process	IEP	Predicted GO
BP	GO:0019439	aromatic compound catabolic process	IEP	Predicted GO
BP	GO:0019637	organophosphate metabolic process	IEP	Predicted GO
BP	GO:0019693	ribose phosphate metabolic process	IEP	Predicted GO
BP	GO:0019752	carboxylic acid metabolic process	IEP	Predicted GO
MF	GO:0019829	cation-transporting ATPase activity	IEP	Predicted GO
MF	GO:0022832	voltage-gated channel activity	IEP	Predicted GO
MF	GO:0022853	active ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0030145	manganese ion binding	IEP	Predicted GO
MF	GO:0030247	polysaccharide binding	IEP	Predicted GO
MF	GO:0030955	potassium ion binding	IEP	Predicted GO
MF	GO:0031420	alkali metal ion binding	IEP	Predicted GO
CC	GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	IEP	Predicted GO
BP	GO:0034220	ion transmembrane transport	IEP	Predicted GO
BP	GO:0034654	nucleobase-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0034655	nucleobase-containing compound catabolic process	IEP	Predicted GO
MF	GO:0042625	ATPase coupled ion transmembrane transporter activity	IEP	Predicted GO
BP	GO:0043436	oxoacid metabolic process	IEP	Predicted GO
BP	GO:0044270	cellular nitrogen compound catabolic process	IEP	Predicted GO
BP	GO:0044283	small molecule biosynthetic process	IEP	Predicted GO
MF	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	IEP	Predicted GO
CC	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	IEP	Predicted GO
BP	GO:0046034	ATP metabolic process	IEP	Predicted GO
BP	GO:0046390	ribose phosphate biosynthetic process	IEP	Predicted GO
BP	GO:0046394	carboxylic acid biosynthetic process	IEP	Predicted GO
BP	GO:0046700	heterocycle catabolic process	IEP	Predicted GO
BP	GO:0046834	lipid phosphorylation	IEP	Predicted GO
BP	GO:0046854	phosphatidylinositol phosphorylation	IEP	Predicted GO
MF	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	IEP	Predicted GO
MF	GO:0047750	cholestenol delta-isomerase activity	IEP	Predicted GO
MF	GO:0050145	nucleoside monophosphate kinase activity	IEP	Predicted GO
MF	GO:0050662	coenzyme binding	IEP	Predicted GO
BP	GO:0051188	cofactor biosynthetic process	IEP	Predicted GO
MF	GO:0051287	NAD binding	IEP	Predicted GO
BP	GO:0052803	imidazole-containing compound metabolic process	IEP	Predicted GO
BP	GO:0055114	oxidation-reduction process	IEP	Predicted GO
MF	GO:0070566	adenylyltransferase activity	IEP	Predicted GO
BP	GO:0072521	purine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072522	purine-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0072593	reactive oxygen species metabolic process	IEP	Predicted GO
BP	GO:0090407	organophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0098655	cation transmembrane transport	IEP	Predicted GO
BP	GO:0098660	inorganic ion transmembrane transport	IEP	Predicted GO
BP	GO:0098662	inorganic cation transmembrane transport	IEP	Predicted GO
BP	GO:1901137	carbohydrate derivative biosynthetic process	IEP	Predicted GO
BP	GO:1901293	nucleoside phosphate biosynthetic process	IEP	Predicted GO
BP	GO:1901361	organic cyclic compound catabolic process	IEP	Predicted GO
BP	GO:1901605	alpha-amino acid metabolic process	IEP	Predicted GO
BP	GO:1901607	alpha-amino acid biosynthetic process	IEP	Predicted GO
BP	GO:1902600	proton transmembrane transport	IEP	Predicted GO
MF	GO:2001070	starch binding	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR001754	OMPdeCOase_dom	247	466
IPR000836	PRibTrfase_dom	45	154

External Links

No external refs found!

Kfl00420_0020 (kfl00420_0020_v1.1)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation