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- MA_10436331g0040
MA_10436331g0040
Description : (at2g30110 : 1273.0) Encodes a ubiquitin-activating enzyme (E1), involved in the first step in conjugating multiple ubiquitins to proteins targeted for degradation. Gene is expressed in most tissues examined. Mutant is able to revert the constitutive defense responses phenotype of snc1, which indicates the gene is involved in defense response. It also indicates that ubiquitination plays a role in plant defense signalling.; ubiquitin-activating enzyme 1 (UBA1); FUNCTIONS IN: ubiquitin-protein ligase activity, ubiquitin activating enzyme activity; INVOLVED IN: response to cadmium ion, response to other organism, protein ubiquitination, ubiquitin-dependent protein catabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-activating enzyme, E1, active site (InterPro:IPR018074), Ubiquitin-activating enzyme, E1 (InterPro:IPR018075), Ubiquitin-activating enzyme e1, C-terminal (InterPro:IPR018965), Ubiquitin-activating enzyme repeat (InterPro:IPR000127), Ubiquitin-activating enzyme (InterPro:IPR019572), UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040), Ubiquitin-activating enzyme, E1-like (InterPro:IPR000011); BEST Arabidopsis thaliana protein match is: ubiquitin activating enzyme 2 (TAIR:AT5G06460.1); Has 19490 Blast hits to 12603 proteins in 2346 species: Archae - 393; Bacteria - 11015; Metazoa - 2131; Fungi - 1366; Plants - 791; Viruses - 0; Other Eukaryotes - 3794 (source: NCBI BLink). & (p31251|ube12_wheat : 1272.0) Ubiquitin-activating enzyme E1 2 - Triticum aestivum (Wheat) & (reliability: 2546.0) & (original description: no original description)
Expression Profile
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Co-expression Networks
| Type | Description | Actions |
| Neighborhood | Picea release: MA_10436331g0040 | |
| Cluster | HCCA clusters: Cluster_20 | |
Expression Context Conservation (ECC)
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
| GRMZM2G111818 | No alias | ubiquitin activating enzyme 2 | 0.06 | Orthogroups_2024-Update | |
| PSME_00041857-RA | No alias | (p31251|ube12_wheat : 1366.0) Ubiquitin-activating... | 0.02 | Orthogroups_2024-Update | |
Functional Annotation
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0003674 | molecular_function | None | Extended |
| MF | GO:0003735 | structural constituent of ribosome | IEA | InterProScan predictions |
| MF | GO:0003824 | catalytic activity | None | Extended |
| MF | GO:0005198 | structural molecule activity | None | Extended |
| CC | GO:0005575 | cellular_component | None | Extended |
| CC | GO:0005622 | intracellular | IEA | InterProScan predictions |
| CC | GO:0005840 | ribosome | IEA | InterProScan predictions |
| BP | GO:0006412 | translation | IEA | InterProScan predictions |
| BP | GO:0006518 | peptide metabolic process | None | Extended |
| BP | GO:0006807 | nitrogen compound metabolic process | None | Extended |
| BP | GO:0008150 | biological_process | None | Extended |
| BP | GO:0008152 | metabolic process | None | Extended |
| MF | GO:0008641 | ubiquitin-like modifier activating enzyme activity | IEA | InterProScan predictions |
| BP | GO:0009058 | biosynthetic process | None | Extended |
| BP | GO:0009059 | macromolecule biosynthetic process | None | Extended |
| BP | GO:0009987 | cellular process | None | Extended |
| MF | GO:0016874 | ligase activity | None | Extended |
| MF | GO:0016877 | ligase activity, forming carbon-sulfur bonds | None | Extended |
| BP | GO:0019538 | protein metabolic process | None | Extended |
| CC | GO:0032991 | protein-containing complex | None | Extended |
| BP | GO:0034641 | cellular nitrogen compound metabolic process | None | Extended |
| BP | GO:0034645 | cellular macromolecule biosynthetic process | None | Extended |
| BP | GO:0043043 | peptide biosynthetic process | None | Extended |
| BP | GO:0043170 | macromolecule metabolic process | None | Extended |
| CC | GO:0043226 | organelle | None | Extended |
| CC | GO:0043228 | non-membrane-bounded organelle | None | Extended |
| CC | GO:0043229 | intracellular organelle | None | Extended |
| CC | GO:0043232 | intracellular non-membrane-bounded organelle | None | Extended |
| BP | GO:0043603 | cellular amide metabolic process | None | Extended |
| BP | GO:0043604 | amide biosynthetic process | None | Extended |
| BP | GO:0044237 | cellular metabolic process | None | Extended |
| BP | GO:0044238 | primary metabolic process | None | Extended |
| BP | GO:0044249 | cellular biosynthetic process | None | Extended |
| BP | GO:0044260 | cellular macromolecule metabolic process | None | Extended |
| BP | GO:0044267 | cellular protein metabolic process | None | Extended |
| BP | GO:0044271 | cellular nitrogen compound biosynthetic process | None | Extended |
| CC | GO:0044424 | intracellular part | None | Extended |
| CC | GO:0044444 | cytoplasmic part | None | Extended |
| CC | GO:0044464 | cell part | None | Extended |
| BP | GO:0071704 | organic substance metabolic process | None | Extended |
| BP | GO:1901564 | organonitrogen compound metabolic process | None | Extended |
| BP | GO:1901566 | organonitrogen compound biosynthetic process | None | Extended |
| BP | GO:1901576 | organic substance biosynthetic process | None | Extended |
| CC | GO:1990904 | ribonucleoprotein complex | None | Extended |
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0003676 | nucleic acid binding | IEP | Predicted GO |
| MF | GO:0003723 | RNA binding | IEP | Predicted GO |
| MF | GO:0003743 | translation initiation factor activity | IEP | Predicted GO |
| BP | GO:0006413 | translational initiation | IEP | Predicted GO |
| MF | GO:0008135 | translation factor activity, RNA binding | IEP | Predicted GO |
