MA_20909g0010

Description : (p09342|ilv1_tobac : 877.0) Acetolactate synthase 1, chloroplast precursor (EC 2.2.1.6) (Acetolactate synthase I) (Acetohydroxy-acid synthase I) (ALS I) - Nicotiana tabacum (Common tobacco) & (at3g48560 : 875.0) Catalyzes the formation of acetolactate from pyruvate, the first step in valine and isoleucine biosynthesis. Requires FAD, thiamine pyrophosphate and Mg. Inhibited by the sulphonylurea herbicide, chlorsulphuron, and the imidazolinone herbicide, imazapyr. The obtained crystal structure of acetohydroxyacid synthase AHAS, EC 2.2.1.6)in complex with herbicides of the sulphonylurea and imidazolinone family reveals the molecular basis for substrate/inhibitor binding.; chlorsulfuron/imidazolinone resistant 1 (CSR1); FUNCTIONS IN: acetolactate synthase activity, pyruvate decarboxylase activity; INVOLVED IN: branched chain family amino acid biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: TPP-binding enzyme, conserved site (InterPro:IPR000399), Thiamine pyrophosphate enzyme, central domain (InterPro:IPR012000), Acetolactate synthase, large subunit, biosynthetic (InterPro:IPR012846), Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain (InterPro:IPR012001), Thiamine pyrophosphate enzyme, C-terminal TPP-binding (InterPro:IPR011766); BEST Arabidopsis thaliana protein match is: Thiamine pyrophosphate dependent pyruvate decarboxylase family protein (TAIR:AT5G17380.1); Has 30963 Blast hits to 30605 proteins in 2694 species: Archae - 488; Bacteria - 17421; Metazoa - 266; Fungi - 871; Plants - 599; Viruses - 25; Other Eukaryotes - 11293 (source: NCBI BLink). & (reliability: 1750.0) & (original description: no original description)

Gene families : OG_42_0003559 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0003559_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Picea release: MA_20909g0010
Cluster	HCCA clusters: Cluster_23

Target	Alias	Description	ECC score	Gene Family Method
Glyma.06G169700	No alias	chlorsulfuron/imidazolinone resistant 1	0.06	Orthogroups_2024-Update
HORVU6Hr1G072320.1	No alias	catalytic component of acetolactate synthase complex &...	0.02	Orthogroups_2024-Update
Sobic.004G155800.2	No alias	catalytic component of acetolactate synthase complex &...	0.02	Orthogroups_2024-Update
Sopen07g030210	No alias	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	0.03	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000287	magnesium ion binding	IEA	InterProScan predictions
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
MF	GO:0019842	vitamin binding	None	Extended
MF	GO:0030976	thiamine pyrophosphate binding	IEA	InterProScan predictions
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
MF	GO:0046872	metal ion binding	None	Extended
MF	GO:0048037	cofactor binding	None	Extended
MF	GO:0050662	coenzyme binding	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
MF	GO:1901681	sulfur compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEP	Predicted GO
BP	GO:0000413	protein peptidyl-prolyl isomerization	IEP	Predicted GO
MF	GO:0001882	nucleoside binding	IEP	Predicted GO
MF	GO:0001883	purine nucleoside binding	IEP	Predicted GO
MF	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IEP	Predicted GO
MF	GO:0003924	GTPase activity	IEP	Predicted GO
MF	GO:0004014	adenosylmethionine decarboxylase activity	IEP	Predicted GO
MF	GO:0004096	catalase activity	IEP	Predicted GO
MF	GO:0004332	fructose-bisphosphate aldolase activity	IEP	Predicted GO
MF	GO:0004356	glutamate-ammonia ligase activity	IEP	Predicted GO
MF	GO:0004618	phosphoglycerate kinase activity	IEP	Predicted GO
MF	GO:0005525	GTP binding	IEP	Predicted GO
CC	GO:0005779	integral component of peroxisomal membrane	IEP	Predicted GO
BP	GO:0006082	organic acid metabolic process	IEP	Predicted GO
BP	GO:0006090	pyruvate metabolic process	IEP	Predicted GO
BP	GO:0006091	generation of precursor metabolites and energy	IEP	Predicted GO
BP	GO:0006096	glycolytic process	IEP	Predicted GO
BP	GO:0006163	purine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0006164	purine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0006165	nucleoside diphosphate phosphorylation	IEP	Predicted GO
BP	GO:0006520	cellular amino acid metabolic process	IEP	Predicted GO
BP	GO:0006536	glutamate metabolic process	IEP	Predicted GO
BP	GO:0006537	glutamate biosynthetic process	IEP	Predicted GO
BP	GO:0006541	glutamine metabolic process	IEP	Predicted GO
BP	GO:0006542	glutamine biosynthetic process	IEP	Predicted GO
BP	GO:0006595	polyamine metabolic process	IEP	Predicted GO
BP	GO:0006596	polyamine biosynthetic process	IEP	Predicted GO
BP	GO:0006597	spermine biosynthetic process	IEP	Predicted GO
BP	GO:0006732	coenzyme metabolic process	IEP	Predicted GO
BP	GO:0006733	oxidoreduction coenzyme metabolic process	IEP	Predicted GO
BP	GO:0006753	nucleoside phosphate metabolic process	IEP	Predicted GO
BP	GO:0006754	ATP biosynthetic process	IEP	Predicted GO
BP	GO:0006757	ATP generation from ADP	IEP	Predicted GO
BP	GO:0006778	porphyrin-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006779	porphyrin-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0008215	spermine metabolic process	IEP	Predicted GO
BP	GO:0008216	spermidine metabolic process	IEP	Predicted GO
BP	GO:0008295	spermidine biosynthetic process	IEP	Predicted GO
BP	GO:0008652	cellular amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009058	biosynthetic process	IEP	Predicted GO
BP	GO:0009064	glutamine family amino acid metabolic process	IEP	Predicted GO
BP	GO:0009084	glutamine family amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009108	coenzyme biosynthetic process	IEP	Predicted GO
BP	GO:0009117	nucleotide metabolic process	IEP	Predicted GO
BP	GO:0009123	nucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009124	nucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009126	purine nucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009127	purine nucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009132	nucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009135	purine nucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009141	nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009142	nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009144	purine nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009145	purine nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009150	purine ribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009152	purine ribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009156	ribonucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009161	ribonucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009165	nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009166	nucleotide catabolic process	IEP	Predicted GO
BP	GO:0009167	purine ribonucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009179	purine ribonucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009185	ribonucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009199	ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009201	ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009205	purine ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009206	purine ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009259	ribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009260	ribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009309	amine biosynthetic process	IEP	Predicted GO
MF	GO:0010277	chlorophyllide a oxygenase [overall] activity	IEP	Predicted GO
MF	GO:0015930	glutamate synthase activity	IEP	Predicted GO
BP	GO:0015994	chlorophyll metabolic process	IEP	Predicted GO
BP	GO:0015995	chlorophyll biosynthetic process	IEP	Predicted GO
BP	GO:0016052	carbohydrate catabolic process	IEP	Predicted GO
BP	GO:0016053	organic acid biosynthetic process	IEP	Predicted GO
MF	GO:0016211	ammonia ligase activity	IEP	Predicted GO
MF	GO:0016462	pyrophosphatase activity	IEP	Predicted GO
BP	GO:0016559	peroxisome fission	IEP	Predicted GO
MF	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	IEP	Predicted GO
MF	GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	IEP	Predicted GO
MF	GO:0016774	phosphotransferase activity, carboxyl group as acceptor	IEP	Predicted GO
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	IEP	Predicted GO
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEP	Predicted GO
MF	GO:0016830	carbon-carbon lyase activity	IEP	Predicted GO
MF	GO:0016832	aldehyde-lyase activity	IEP	Predicted GO
MF	GO:0016851	magnesium chelatase activity	IEP	Predicted GO
MF	GO:0016853	isomerase activity	IEP	Predicted GO
MF	GO:0016854	racemase and epimerase activity	IEP	Predicted GO
MF	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	IEP	Predicted GO
MF	GO:0016859	cis-trans isomerase activity	IEP	Predicted GO
MF	GO:0016874	ligase activity	IEP	Predicted GO
MF	GO:0016880	acid-ammonia (or amide) ligase activity	IEP	Predicted GO
BP	GO:0017038	protein import	IEP	Predicted GO
MF	GO:0017111	nucleoside-triphosphatase activity	IEP	Predicted GO
BP	GO:0017144	drug metabolic process	IEP	Predicted GO
BP	GO:0018130	heterocycle biosynthetic process	IEP	Predicted GO
BP	GO:0018208	peptidyl-proline modification	IEP	Predicted GO
MF	GO:0019001	guanyl nucleotide binding	IEP	Predicted GO
BP	GO:0019359	nicotinamide nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0019362	pyridine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0019363	pyridine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0019438	aromatic compound biosynthetic process	IEP	Predicted GO
BP	GO:0019439	aromatic compound catabolic process	IEP	Predicted GO
BP	GO:0019693	ribose phosphate metabolic process	IEP	Predicted GO
BP	GO:0019752	carboxylic acid metabolic process	IEP	Predicted GO
CC	GO:0031231	intrinsic component of peroxisomal membrane	IEP	Predicted GO
CC	GO:0031300	intrinsic component of organelle membrane	IEP	Predicted GO
CC	GO:0031301	integral component of organelle membrane	IEP	Predicted GO
MF	GO:0032549	ribonucleoside binding	IEP	Predicted GO
MF	GO:0032550	purine ribonucleoside binding	IEP	Predicted GO
MF	GO:0032553	ribonucleotide binding	IEP	Predicted GO
MF	GO:0032561	guanyl ribonucleotide binding	IEP	Predicted GO
BP	GO:0032787	monocarboxylic acid metabolic process	IEP	Predicted GO
BP	GO:0033013	tetrapyrrole metabolic process	IEP	Predicted GO
BP	GO:0033014	tetrapyrrole biosynthetic process	IEP	Predicted GO
BP	GO:0034404	nucleobase-containing small molecule biosynthetic process	IEP	Predicted GO
BP	GO:0034655	nucleobase-containing compound catabolic process	IEP	Predicted GO
MF	GO:0035639	purine ribonucleoside triphosphate binding	IEP	Predicted GO
BP	GO:0042401	cellular biogenic amine biosynthetic process	IEP	Predicted GO
BP	GO:0042440	pigment metabolic process	IEP	Predicted GO
BP	GO:0042866	pyruvate biosynthetic process	IEP	Predicted GO
BP	GO:0043436	oxoacid metabolic process	IEP	Predicted GO
BP	GO:0043648	dicarboxylic acid metabolic process	IEP	Predicted GO
BP	GO:0043650	dicarboxylic acid biosynthetic process	IEP	Predicted GO
BP	GO:0044249	cellular biosynthetic process	IEP	Predicted GO
BP	GO:0044270	cellular nitrogen compound catabolic process	IEP	Predicted GO
BP	GO:0044271	cellular nitrogen compound biosynthetic process	IEP	Predicted GO
BP	GO:0044281	small molecule metabolic process	IEP	Predicted GO
BP	GO:0044283	small molecule biosynthetic process	IEP	Predicted GO
CC	GO:0044438	microbody part	IEP	Predicted GO
CC	GO:0044439	peroxisomal part	IEP	Predicted GO
BP	GO:0046031	ADP metabolic process	IEP	Predicted GO
BP	GO:0046034	ATP metabolic process	IEP	Predicted GO
BP	GO:0046148	pigment biosynthetic process	IEP	Predicted GO
BP	GO:0046390	ribose phosphate biosynthetic process	IEP	Predicted GO
BP	GO:0046394	carboxylic acid biosynthetic process	IEP	Predicted GO
MF	GO:0046406	magnesium protoporphyrin IX methyltransferase activity	IEP	Predicted GO
BP	GO:0046434	organophosphate catabolic process	IEP	Predicted GO
BP	GO:0046496	nicotinamide nucleotide metabolic process	IEP	Predicted GO
BP	GO:0046700	heterocycle catabolic process	IEP	Predicted GO
BP	GO:0046939	nucleotide phosphorylation	IEP	Predicted GO
BP	GO:0048285	organelle fission	IEP	Predicted GO
MF	GO:0051002	ligase activity, forming nitrogen-metal bonds	IEP	Predicted GO
MF	GO:0051003	ligase activity, forming nitrogen-metal bonds, forming coordination complexes	IEP	Predicted GO
BP	GO:0051186	cofactor metabolic process	IEP	Predicted GO
BP	GO:0051188	cofactor biosynthetic process	IEP	Predicted GO
MF	GO:0051537	2 iron, 2 sulfur cluster binding	IEP	Predicted GO
BP	GO:0055086	nucleobase-containing small molecule metabolic process	IEP	Predicted GO
BP	GO:0055114	oxidation-reduction process	IEP	Predicted GO
MF	GO:0071949	FAD binding	IEP	Predicted GO
BP	GO:0072330	monocarboxylic acid biosynthetic process	IEP	Predicted GO
BP	GO:0072521	purine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072522	purine-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0072524	pyridine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072525	pyridine-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0090407	organophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0097164	ammonium ion metabolic process	IEP	Predicted GO
MF	GO:0097367	carbohydrate derivative binding	IEP	Predicted GO
BP	GO:1901137	carbohydrate derivative biosynthetic process	IEP	Predicted GO
MF	GO:1901265	nucleoside phosphate binding	IEP	Predicted GO
BP	GO:1901292	nucleoside phosphate catabolic process	IEP	Predicted GO
BP	GO:1901293	nucleoside phosphate biosynthetic process	IEP	Predicted GO
BP	GO:1901361	organic cyclic compound catabolic process	IEP	Predicted GO
BP	GO:1901362	organic cyclic compound biosynthetic process	IEP	Predicted GO
BP	GO:1901566	organonitrogen compound biosynthetic process	IEP	Predicted GO
BP	GO:1901576	organic substance biosynthetic process	IEP	Predicted GO
BP	GO:1901605	alpha-amino acid metabolic process	IEP	Predicted GO
BP	GO:1901607	alpha-amino acid biosynthetic process	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR012000	Thiamin_PyroP_enz_cen_dom	274	336
IPR012000	Thiamin_PyroP_enz_cen_dom	337	421
IPR012001	Thiamin_PyroP_enz_TPP-bd_dom	82	247
IPR011766	TPP_enzyme-bd_C	481	636

External Links

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MA_20909g0010

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation