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- PSME_00016559-RA
PSME_00016559-RA
Description : (o24308|top2_pea : 1626.0) DNA topoisomerase 2 (EC 5.99.1.3) (DNA topoisomerase II) (PsTopII) - Pisum sativum (Garden pea) & (at3g23890 : 1624.0) Encodes a topoisomerase II that is highly expressed in young seedlings. The protein is localized in the nucleus and gene expression levels are increased in proliferative tissues.; topoisomerase II (TOPII); CONTAINS InterPro DOMAIN/s: DNA topoisomerase, type IIA, subunit A/C-terminal (InterPro:IPR002205), DNA topoisomerase, type IIA, conserved site (InterPro:IPR018522), DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta (InterPro:IPR013758), DNA topoisomerase, type IIA, subunit B, domain 2 (InterPro:IPR013506), DNA topoisomerase, type IIA, subunit A, alpha-helical (InterPro:IPR013757), ATPase-like, ATP-binding domain (InterPro:IPR003594), DNA topoisomerase, type IIA, subunit B/N-terminal, alpha-beta (InterPro:IPR013759), DNA topoisomerase, type IIA, subunit B/N-terminal (InterPro:IPR001241), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), DNA topoisomerase II, eukaryotic-type (InterPro:IPR001154), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721), DNA topoisomerase, type IIA, central (InterPro:IPR013760); BEST Arabidopsis thaliana protein match is: DNA GYRASE B2 (TAIR:AT5G04130.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink). & (reliability: 3248.0) & (original description: no original description)
Expression Profile
Attention: This gene has low abundance.
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Co-expression Networks
Type | Description | Actions |
Neighborhood | Pseudotsuga release: PSME_00016559-RA | |
Cluster | HCCA clusters: Cluster_10 | |
Expression Context Conservation (ECC)
Target | Alias | Description | ECC score | Gene Family Method | Actions |
98330 | No alias | topoisomerase II | 0.06 | Orthogroups_2024-Update | |
At3g23890 | No alias | DNA topoisomerase 2 [Source:UniProtKB/Swiss-Prot;Acc:P30182] | 0.03 | Orthogroups_2024-Update | |
Brara.A00830.1 | No alias | DNA topoisomerase *(TOP2) | 0.04 | Orthogroups_2024-Update | |
Cre01.g009250 | No alias | topoisomerase II | 0.01 | Orthogroups_2024-Update | |
Glyma.10G090000 | No alias | topoisomerase II | 0.04 | Orthogroups_2024-Update | |
Glyma.15G276000 | No alias | topoisomerase II | 0.04 | Orthogroups_2024-Update | |
Kfl00053_0310 | kfl00053_0310_v1.1 | (o24308|top2_pea : 1259.0) DNA topoisomerase 2 (EC... | 0.03 | Orthogroups_2024-Update | |
MA_133272g0010 | No alias | (at3g23890 : 1518.0) Encodes a topoisomerase II that is... | 0.04 | Orthogroups_2024-Update | |
MA_6634g0010 | No alias | (o24308|top2_pea : 1595.0) DNA topoisomerase 2 (EC... | 0.04 | Orthogroups_2024-Update | |
Mp3g13420.1 | No alias | DNA topoisomerase (TOP2) | 0.03 | Orthogroups_2024-Update | |
Pp1s33_203V6 | No alias | dna topoisomerase ii | 0.03 | Orthogroups_2024-Update | |
Solyc01g087500 | No alias | DNA topoisomerase 2 (AHRD V3.3 *** K4AYE0_SOLLC) | 0.03 | Orthogroups_2024-Update | |
evm.model.contig_3477.2 | No alias | (at3g23890 : 1176.0) Encodes a topoisomerase II that is... | 0.03 | Orthogroups_2024-Update | |
evm.model.tig00021432.55 | No alias | (o24308|top2_pea : 775.0) DNA topoisomerase 2 (EC... | 0.02 | Orthogroups_2024-Update | |
evm.model.tig00021433.1 | No alias | (at3g23890 : 211.0) Encodes a topoisomerase II that is... | 0.05 | Orthogroups_2024-Update | |
evm.model.tig00021433.2 | No alias | (at3g23890 : 475.0) Encodes a topoisomerase II that is... | 0.04 | Orthogroups_2024-Update | |
Functional Annotation
Type | GO Term | Name | Evidence | Source |
MF | GO:0000166 | nucleotide binding | None | Extended |
MF | GO:0003674 | molecular_function | None | Extended |
MF | GO:0003676 | nucleic acid binding | None | Extended |
MF | GO:0003677 | DNA binding | IEA | InterProScan predictions |
MF | GO:0003824 | catalytic activity | None | Extended |
MF | GO:0003916 | DNA topoisomerase activity | None | Extended |
MF | GO:0003918 | DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | InterProScan predictions |
MF | GO:0005488 | binding | None | Extended |
MF | GO:0005524 | ATP binding | IEA | InterProScan predictions |
BP | GO:0006139 | nucleobase-containing compound metabolic process | None | Extended |
BP | GO:0006259 | DNA metabolic process | None | Extended |
BP | GO:0006265 | DNA topological change | IEA | InterProScan predictions |
BP | GO:0006725 | cellular aromatic compound metabolic process | None | Extended |
BP | GO:0006807 | nitrogen compound metabolic process | None | Extended |
BP | GO:0006996 | organelle organization | None | Extended |
MF | GO:0008094 | DNA-dependent ATPase activity | None | Extended |
MF | GO:0008144 | drug binding | None | Extended |
BP | GO:0008150 | biological_process | None | Extended |
BP | GO:0008152 | metabolic process | None | Extended |
BP | GO:0009987 | cellular process | None | Extended |
BP | GO:0016043 | cellular component organization | None | Extended |
MF | GO:0016462 | pyrophosphatase activity | None | Extended |
MF | GO:0016787 | hydrolase activity | None | Extended |
MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | None | Extended |
MF | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | None | Extended |
MF | GO:0016853 | isomerase activity | None | Extended |
MF | GO:0016887 | ATPase activity | None | Extended |
MF | GO:0017076 | purine nucleotide binding | None | Extended |
MF | GO:0017111 | nucleoside-triphosphatase activity | None | Extended |
MF | GO:0030554 | adenyl nucleotide binding | None | Extended |
MF | GO:0032553 | ribonucleotide binding | None | Extended |
MF | GO:0032555 | purine ribonucleotide binding | None | Extended |
MF | GO:0032559 | adenyl ribonucleotide binding | None | Extended |
BP | GO:0034641 | cellular nitrogen compound metabolic process | None | Extended |
MF | GO:0035639 | purine ribonucleoside triphosphate binding | None | Extended |
MF | GO:0036094 | small molecule binding | None | Extended |
MF | GO:0042623 | ATPase activity, coupled | None | Extended |
MF | GO:0043167 | ion binding | None | Extended |
MF | GO:0043168 | anion binding | None | Extended |
BP | GO:0043170 | macromolecule metabolic process | None | Extended |
BP | GO:0044237 | cellular metabolic process | None | Extended |
BP | GO:0044238 | primary metabolic process | None | Extended |
BP | GO:0044260 | cellular macromolecule metabolic process | None | Extended |
BP | GO:0046483 | heterocycle metabolic process | None | Extended |
BP | GO:0051276 | chromosome organization | None | Extended |
MF | GO:0061505 | DNA topoisomerase II activity | None | Extended |
BP | GO:0071103 | DNA conformation change | None | Extended |
BP | GO:0071704 | organic substance metabolic process | None | Extended |
BP | GO:0071840 | cellular component organization or biogenesis | None | Extended |
BP | GO:0090304 | nucleic acid metabolic process | None | Extended |
MF | GO:0097159 | organic cyclic compound binding | None | Extended |
MF | GO:0097367 | carbohydrate derivative binding | None | Extended |
MF | GO:0140097 | catalytic activity, acting on DNA | None | Extended |
MF | GO:1901265 | nucleoside phosphate binding | None | Extended |
BP | GO:1901360 | organic cyclic compound metabolic process | None | Extended |
MF | GO:1901363 | heterocyclic compound binding | None | Extended |
Type | GO Term | Name | Evidence | Source |
MF | GO:0003993 | acid phosphatase activity | IEP | Predicted GO |
MF | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | IEP | Predicted GO |
MF | GO:0005506 | iron ion binding | IEP | Predicted GO |
BP | GO:0006260 | DNA replication | IEP | Predicted GO |
BP | GO:0006270 | DNA replication initiation | IEP | Predicted GO |
MF | GO:0016491 | oxidoreductase activity | IEP | Predicted GO |
MF | GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEP | Predicted GO |
MF | GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups | IEP | Predicted GO |
MF | GO:0016728 | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor | IEP | Predicted GO |
MF | GO:0016791 | phosphatase activity | IEP | Predicted GO |
MF | GO:0020037 | heme binding | IEP | Predicted GO |
MF | GO:0042578 | phosphoric ester hydrolase activity | IEP | Predicted GO |
MF | GO:0043169 | cation binding | IEP | Predicted GO |
MF | GO:0046872 | metal ion binding | IEP | Predicted GO |
MF | GO:0046906 | tetrapyrrole binding | IEP | Predicted GO |
MF | GO:0046914 | transition metal ion binding | IEP | Predicted GO |
MF | GO:0048037 | cofactor binding | IEP | Predicted GO |
BP | GO:0055114 | oxidation-reduction process | IEP | Predicted GO |
MF | GO:0061731 | ribonucleoside-diphosphate reductase activity | IEP | Predicted GO |